Substance P and Prostaglandin E2 Release After Shock Wave Application to the Rabbit Femur

Maier, Markus; Averbeck, Beate; Milz, Stefan; Refior, H J; Schmitz, Christoph

doi:10.1097/00003086-200301000-00034

Cited by 127 publications

(81 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pain reduction obtained in both groups confirmed the effectiveness of ESWT in stimulating analgesia through modulation of pain chemical mediators such as blocking of pain signal transmission induced by substance P (29)(30)(31)(32)(33)(34)(35).…”

Section: Discussionsupporting

confidence: 64%

Chronic Ulcers: Treatment with Unfocused Extracorporeal Shock Waves

et al. 2013

View full text Add to dashboard Cite

The aim of this study was to evaluate the efficacy of the treatment of chronic ulcers with unfocused shock waves. Between March 2009 and February 2012 we studied a group of 124 patients, aged between 28 and 80 years, with serious wounds arisen over three months and who met the inclusion criteria for treatment. The patients were randomly divided into groups A and B, both treated with unfocused ESWT but with an average energy density for each impulse equal to 0.10 m.l/mm' in group A (total energy equal to 1.7 mJ for each shot) and an average energy density for each impulse equal to 0.04 m.I/mm-in group B (total energy equal to 3.3 mJ for each shot). The pulses were administered at a frequency of 4 Hz in both groups. Wounds were classified according to: location, width, length, percentage of granulation tissue, necrotic tissue, fibrous tissue, presence of bacterial exudation and pain (assessed by VAS). Their evolution was monitored by photo capture. The patients were treated with a frequency of 1 session every 7 days for 7 weeks. During the treatment period, the possible occurrence of side effects was monitored. Before treatment the wounds in group A had an average area equal to 3.85 em-and the average value of the VAS pain scale was equal to 5.8 (range 2-9); the wounds in group B had an average area equal to 3.4 ern" and the average value ofthe VAS pain scale was equal to 5.7 (range 3-9). At the end of the treatment protocol the mean area in group A decreased by 80% (final mean area 0.93 em"), and the average pain on VAS scale dropped by 79%; the mean area in group B decreased by 67% (final mean area 1.2 ern") and the average score on VAS scale dropped by 48%. None of the treated patients experienced adverse reactions to treatment. None of the treated wounds developed infection during treatment. In conclusion, shock waves can act on difficult wounds, stimulating the reparative physiological process; therefore it represents an effective and safe procedure to accelerate the healing process, reducing the operating costs and avoiding more complex interventions.Chronic ulcers are complex wounds that do not heal spontaneously and are usually associated with local and systemic predisposing factors (1).Wound healing is a dynamic process influenced by homeostatic balance, inflammatory and matrixsynthesis process, and by an appropriate process

show abstract

Section: Discussionsupporting

confidence: 64%

Chronic Ulcers: Treatment with Unfocused Extracorporeal Shock Waves

et al. 2013

View full text Add to dashboard Cite

show abstract

“…However, in the shock wave-treated group, the percentage decreased to 18%. Maier et al [32] showed that highenergy ESWT (1 500 impulses, EFD = 0.90 mJ/mm2) to the distal rabbit femur resulted in a reduced concentration of substance P in the femoral periosteum 6 weeks after shock wave application. Substance P is concentrated in unmyelinated C-fibers and a subpopulation of slowly conducting, lightly myelinated A-6 nerve fibers, and is released at central and peripheral terminals of sensory nociceptive neurons after stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…These studies [32,33,37,53,54] indicate that shock waves may selectively lead to dysfunction of peripheral sensory unmyelinated nerve fibers without affecting nerve fibers responsible for motor function (large myeh a t e d fibers). For high-energy treatment, this selective destruction of unmyelinated sensory nerve fibers within the focal zone of ESWT may contribute to clinically evident long-term analgesia.…”

Section: Discussionmentioning

confidence: 99%

Repetitive low‐energy shock wave application without local anesthesia is more efficient than repetitive low‐energy shock wave application with local anesthesia in the treatment of chronic plantar fasciitis

Rompe

Meurer

Nafe

et al. 2005

Journal Orthopaedic Research

View full text Add to dashboard Cite

Background: It remains unclear whether application of local anesthesia (LA) interferes with clinical efficacy of extracorporeal shock wave therapy (ESWT) for chronic plantar fasciitis.Aims: To evaluate the effect of local anesthesia on the clinical outcome after repetitive low-energy ESWT for chronic plantar fasciitis.Methods: Eighty-six patients with chronic plantar fasciitis were randomly assigned to receive either low-energy ESWT without

show abstract

“…Several musculoskeletal entities that have been treated include calcific tendinitis of the shoulder, lateral epicondylitis, delayed union and nonunion of fractures, chronic plantar fasciitis, Achilles and patellar tendinopathies, and osteonecrosis of the femoral head [1][2][3][4][5][6][7][8][9] . Basic-science studies increasingly are providing an understanding of the physiologic mechanisms of pain relief (often immediate) and the modification and repair of the target tissue, which usually requires weeks to months to occur [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] . Extracorporeal shock-wave treatments have been applied to patients with chronic plantar fasciitis who have failed to respond to multiple conservative pharmacologic and therapeutic interventions [29][30][31][32][33][34][35][36][37][38] .…”

Section: Discussionmentioning

confidence: 99%