“…In our previous work [45,46] we performed narrowing deformations in CT extracted lung geometries to simulate constrictive conditions. Other studies in the same category include simulations for CT-based patient specific geometries [47][48][49][50][51][52], particle deposition [53][54][55][56], constrictive pulmonary diseases [45,46,[57][58][59], micro-airway flow regimes [57], turbulence modelling [60], fourdimensional (space and time) dynamic simulations [61], ventilation heterogeneity [57], airflow in the acinar region [62]. Validation studies conducted by Montesantos et al [63] include morphometric studies on healthy and asthmatic patients providing among others, measurements of branching angles, length and diameter of airways as a function of generation.…”