Subsidization of Renal Replacement Therapy in Ghana: Far more overdue

Background: The number of monkeypox cases is rising globally, but it’s unclear how many instances there will be in the near future. The disease has been one of the major problems for sub-Saharan Africans in the past few years. Methods: A deterministic mathematical model incorporating optimal controls has been developed in this research to investigate the transmission of the monkeypox virus. The model’s fundamental properties such as positivity and boundedness of solution, and basic reproduction number have been examined. In order to assess the efficacy of two preventative control strategies—public education and vaccination—optimal controls were included in the model and Pontragyin’s maximum principle used to characterized the model. Results: Public education was found to have less of an effect on those who were vulnerable than vaccine control. However, both approaches were successful in reducing the number of people who were exposed to the illness and reducing the number of fatalities. Additionally, vaccination increases a person’s immunity, which speeds up their recovery. Conclusions: A deterministic classical model incorporating optimal controls was proposed to study the monkeypox virus dynamics in a population. The disease is not endemic, which is explained by the model’s basic reproduction number, which was less than unity. Based on the findings of this study, we advise vaccine control plan as the most effective preventative measure.

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“…https://doi.org/10.17605/OSF.IO/69RYP. 19 This project contains the following underlying data: The benefits of publishing with F1000Research:…”

Section: Data Availabilitymentioning

confidence: 99%

Optimal control model of human-to-human transmission of monkeypox virus

Ackora-Prah

Okyere

Bonyah³

et al. 2023

F1000Res

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“…The outcomes of the MATLAB (version R2016a) (RRID: SCR_001622) [19][20][21] (Python (RRID:SCR_008394) could potentially be used as an open alternative using similar methods described in this manuscript) ODE45 using the parameter values and the initial conditions are shown in Figures 2-25.…”

Section: Optimal Controlmentioning

confidence: 99%

“…https://doi.org/10.17605/OSF.IO/69RYP. 19 This project contains the following underlying data: is incorrect.…”

Section: Data Availabilitymentioning

confidence: 99%

Optimal control model of human-to-human transmission of monkeypox virus

Ackora-Prah,

Okyere,

Bonyah

et al. 2023

F1000Res

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Background: The number of monkeypox cases is rising globally, but it’s unclear how many instances there will be in the near future. The disease has been one of the major problems for sub-Saharan Africans in the past few years. This study seeks to suggest optimal strategies for curbing the disease in Ghana and preventing future occurrences. Methods: A deterministic mathematical model incorporating optimal controls has been developed in this research to investigate the transmission of the monkeypox virus. The model’s fundamental properties such as positivity and boundedness of solution, and basic reproduction number have been examined. In order to assess the efficacy of two preventative control strategies—public education and vaccination—optimal controls were included in the model and Pontragyin’s maximum principle was used to characterize the model. Results: The disease was observed to be not endemic with infection going extinct after ten days. The Monkeypox-related deaths were insignificant. The optimal strategies revealed that public education had less of an effect on those who were vulnerable than the vaccine control strategy. However, both approaches were successful in reducing the number of people who were exposed to the illness and reducing the number of fatalities. Vaccination reduced the number by 32.35% and public education by 50% at the peak of the exposed phase. Additionally, vaccination increases a person’s immunity, which speeds up their recovery. Conclusions: A deterministic classical model incorporating optimal controls was proposed to study the monkeypox virus dynamics in a population. The disease is not endemic, which is explained by the model’s basic reproduction number, which was less than unity. Based on the findings of this study, we advise the use of both strategies in controlling the disease.

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Subsidization of Renal Replacement Therapy in Ghana: Far more overdue

Cited by 2 publications

References 14 publications

Optimal control model of human-to-human transmission of monkeypox virus

Optimal control model of human-to-human transmission of monkeypox virus

Optimal control model of human-to-human transmission of monkeypox virus

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