Subsequent Fractures Post–Vertebral Augmentation: Analysis of a Prospective Randomized Trial in Osteoporotic Vertebral Compression Fractures

Gilula, Louis A.; Persenaire, Maarten

doi:10.3174/ajnr.a3156

Cited by 14 publications

(5 citation statements)

References 27 publications

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“…54 Cortoss (Orthovita; Malvern, PA), a bioactive, injectable, nonresorbable composite consisting of highly cross-linked resins and reinforcing bioactive glass fibers, was also found to have a more physiologic load transfer, and patients treated with Cortoss were less likely to be hospitalized for new vertebral compression fractures. 55 …”

Section: Operative Managementmentioning

confidence: 99%

Evaluation and Management of Vertebral Compression Fractures

Alexandru¹,

So²

2012

TPJ

228

151

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Section: Operative Managementmentioning

confidence: 99%

Evaluation and Management of Vertebral Compression Fractures

Alexandru¹,

So²

2012

TPJ

228

151

View full text Add to dashboard Cite

“…Silicone resin is a feasible option for the treatment of osteoporotic fractures, which has biomechanical potential to reduce the risk of secondary adjacent vertebral fractures [22]. Gilula et al used cortoss cement and PMMA (polymethyl methacrylate) bone cement for surgery, and found that the incidence of secondary adjacent vertebral fractures in the cortoss cement group was lower than that in the PMMA bone cement group [23]. The optimal amount of bone cement is still controversial.…”

Section: Discussionmentioning

confidence: 99%

Comparison of targeted percutaneous vertebroplasty and traditional percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures in the elderly

et al. 2020

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Objective: To investigate the clinical effect of precise puncture and low-dose bone cement in percutaneous vertebroplasty (PVP). Methods: Sixty patients with osteoporotic vertebral compression fracture (OVCFs) who were treated with PVP in our hospital from July 2018 to June 2019. These included patients were divided into group A (N = 30) and group B (N = 30). Group A has punctured to the fracture area accurately and injected with a small dose of bone cement, the group B was injected with a conventional dose of bone cement. The operation time, the amount of bone cement injection, the number of X-rays, the VAS scores, the leakage rate of bone cement, and the incidence of adjacent vertebral fractures were compared between the two groups. Result: The operation time, fluoroscopic times, and bone cement volume in group A are less than that in group B (P < 0.05). Patients in group A had a lower incidence of cement leakage and adjacent vertebral fracture than that in patients in group B. There was no significant difference in postoperative pain relief between the two groups. Conclusions: Precise puncture and injection of small doses of bone cement can reduce the number of X-ray fluoroscopy, operation time, amount of bone cement injection, reduce the rate of bone cement leakage and the incidence of adjacent vertebral fractures, which is a safe and effective surgical approach for the treatment for the aged with OVCFs.

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“…At the same time, increased cement volume fractures were also found to increase adjacent fractures (33). In acute cases, the dispersed fill pattern and load-bearing properties of the bioactive composite may also result in fewer subsequent fractures (23,34). Secondly, repeated compressive loading over the fracture site can lead to bone loss near the end plate.…”

Section: Discussionmentioning

confidence: 99%

Earlier Vertebroplasty for Osteoporotic Thoracolumbar Compression Fracture May Minimize the Subsequent Development of Adjacent Fractures: A Retrospective Study

Lee

2018

Pain Phys

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Background: Percutaneous vertebroplasty (PVP) is widely used to treat osteoporotic vertebral compression fractures (OVCFs). The influence of timing (early vs. late) of PVP on the development of adjacent vertebral fractures (AVF) has rarely been discussed. Objective: This study aimed to compare the incidence of AVF among patients who received early PVP (≤ 30 days after symptom onset, EPVP) or late PVP (> 30 days after symptom onset, LPVP) in the thoracolumbar region (T10 to L2) after a 1-year follow up. Study Design: A retrospective cohort study. Setting: Department of Orthopedic, an affiliated hospital of a medical university. Methods: Patients who had single-level, T-score ≤ -2.5 of lumbar bone mineral density (BMD), primary OVCF in the thoracolumbar region (T10 to L2) and who received PVP between July 2012 and June 2014 were included in the study. They were divided into early PVP and late PVP groups according to the interval between symptom onset and treatment. The risk factors associated with subsequent AVFs were analyzed. Results: Of the 225 patients reviewed, 124 met the criteria and were followed for a minimum of 1 year. Eleven patients (14.1%) in the EPVP group (n = 78) and 18 patients (39.1%) in the LPVP group (n = 46) experienced an AVF during the first year following vertebroplasty. Outcomes were significantly better in patients with higher bone mineral density, lower cement volume, and without cement leakage (P < 0.01). Cox regression indicated an increase risk for AVF for LPVP, with an adjusted hazard ratio of 6.08 (95% confidence interval: 2.50–14.81). Limitation: The incidence of AVFs could be over estimated due to this being a retrospective study with a small case number and lack of either biomechanical study of intra-vertebral cement distribution by times to support the result. Conclusions: Compared with later interventions, PVP performed within 30 days after fracture development may be associated with a lower risk of adjacent fractures in the thoracolumbar region. Key words: Percutaneous vertebroplasty, osteoporosis, osteoporotic vertebral compression fracture, adjacent vertebral fracture

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Subsequent Fractures Post–Vertebral Augmentation: Analysis of a Prospective Randomized Trial in Osteoporotic Vertebral Compression Fractures

Cited by 14 publications

References 27 publications

Evaluation and Management of Vertebral Compression Fractures

Evaluation and Management of Vertebral Compression Fractures

Comparison of targeted percutaneous vertebroplasty and traditional percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures in the elderly

Earlier Vertebroplasty for Osteoporotic Thoracolumbar Compression Fracture May Minimize the Subsequent Development of Adjacent Fractures: A Retrospective Study

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