Subsequent alterations in the contractile property of the vas deferens according to duration of spermatic cord torsion

Karacay, Safak; Sözübir, Selami; Bilge, S. Sırrı; Aksöz, Elif; Ekíngen, Gülşen; Güvenç, B. Haluk

doi:10.1016/j.fertnstert.2011.08.008

Cited by 2 publications

(1 citation statement)

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“…In an attempt to understand the influence of acute ischemia, models of torsion using rats have demonstrated a decrease in contractile response in the ipsilateral vas deferens (Karacay et al, 2011) Interestingly, spontaneous hypertensive rats have shown an INCREASE in contractile response to EFS and NA (Katsuragi et al, 1991), and Gur et al (2010) showed increased contractile respone to purinergic stimulation in L-NG-Nitroarginine Methyl Ester (L-NAME) induced hypertensive rat vas deferens. In conjuction with this study, Gur et al (2010) also demonstrated that rats co-treated with sildenafil and L-NAME reversed this EFS and α−β-methylATP hypercontractile property of the vas deferens.…”

Section: Signal Transductionmentioning

confidence: 99%

Physiological and pharmacological aspects of the vas deferens—an update

Koslov¹,

Andersson²

2013

Front. Pharmacol.

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The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the urethra, has been used as a model tissue for smooth muscle pharmacological and physiological advancements. Many drugs, notably α-adrenergic antagonists, have effects on contractility and thus normal ejaculation, incurring significant side effects for patients that may interfere with compliance. A more thorough understanding of the innervation and neurotransmitter pharmacology of the vas has indicated that this is a highly complex structure and a model for co-transmission at the synapse. Recent models have shown clinical scenarios that alter the vas contraction. This review covers structure, receptors, neurotransmitters, smooth muscle physiology, and clinical implications of the vas deferens.

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