Abstract:Study design: Case series. Objectve: The objective was to study the effect of phenol blocks to the motor points of the subscapularis muscle in patients with cervical cord injury (CCI). Setting: Spinal cord injury units of a national hospital in Tokyo. Methods: The participants were seven patients with traumatic CCI, mean age 55.8 years (SD4.0), whose injury level were at the fifth cervical level and the American Spinal Injury Association (ASIA) impairment scale was A in 2, C in 1 and D in 4. They were at least… Show more
“…Alcohol concentration used in three case series/studies 40,42,44 ranged from 68 to 100%, with volumes between 7.5 and 10 ml. Uchikawa et al 37 injected subscapularis motor points and Koyama et al 41 injected motor points of the psoas muscle. All other studies targeted peripheral nerves in the lower extremities for neurolysis.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…As SCI participants comprised ⩾ 50% of the samples, and we were unable to obtain patient level data, data pertaining to the entire subject group were included. Ghai et al, 35 Yasar et al 39 and Uchikawa et al 37 used MAS as a primary outcome measure, otherwise selection of outcome measures was variable between studies. The three case studies [42][43][44] did not report formal outcome measures and instead provided qualitative descriptions.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…Chemodenervation in spinal cord injury J Lui et al individuals with SCI have been reported in four level 4 pre-post studies [35][36][37][38] and six level 5 studies (5 case series/studies, [40][41][42][43][44] one retrospective chart review 39 ). Results from these studies are summarized in Table 3.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…Nine studies investigated the use of BoNT, [26][27][28][29][30][31][32][33][34] and 10 studies investigated phenol/alcohol [35][36][37][38][39][40][41][42][43][44] for management of spasticity in SCI with chemodenervation. The literature search did not identify any randomized or non-RCTs looking at management of spasticity in a sample population with ⩾ 50% SCI participants, precluding the use of PEDro and Downs and Black Scale for quality assessment.…”
Section: Studiesmentioning
confidence: 99%
“…Results from these studies are summarized in Table 3. Seven [35][36][37][38][39]41,43 of the 10 studies involved phenol injections ranging from 0.3 to 10 ml and 5 to 6% concentration. Alcohol concentration used in three case series/studies 40,42,44 ranged from 68 to 100%, with volumes between 7.5 and 10 ml.…”
Study design: Systematic review. Objectives: To systematically review the literature on chemodenervation with botulinum toxin (BoNT) or phenol/alcohol for treatment of limb spasticity following spinal cord injury (SCI). Setting: British Columbia, Canada. Methods: EMBASE, MEDLINE, CINAHL, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched for English language studies published up until March 2014. Studies were assessed for eligibility and quality by two independent reviewers. Results: No controlled trials were identified. A total of 19 studies were included: 9 involving BoNT and 10 involving phenol/alcohol. Owing to the clinically diverse nature of the studies, meta-analysis was deemed inappropriate. The studies produced level 4 and level 5 evidence that chemodenervation with BoNT or alcohol/phenol can lead to improvement in outcome measurements classified in the body structure and function, as well as activity domains of the International Classification of Functioning, Disability and Health framework. The Modified Ashworth Scale (MAS) was the most commonly used outcome measure. All six studies on BoNT and three of the four studies on phenol/alcohol measuring MAS reported a decrease in at least one point. An improvement in MAS was not always associated with improvement in function. The effect of phenol/alcohol has the potential to last beyond 6 months; study follow-up did not occur beyond this time point. Conclusion Chemodenervation with BoNT or phenol/alcohol may improve spasticity and function in individuals with SCI. However, there is a lack of high-quality evidence and further research is needed to confirm the efficacy of these interventions.
“…Alcohol concentration used in three case series/studies 40,42,44 ranged from 68 to 100%, with volumes between 7.5 and 10 ml. Uchikawa et al 37 injected subscapularis motor points and Koyama et al 41 injected motor points of the psoas muscle. All other studies targeted peripheral nerves in the lower extremities for neurolysis.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…As SCI participants comprised ⩾ 50% of the samples, and we were unable to obtain patient level data, data pertaining to the entire subject group were included. Ghai et al, 35 Yasar et al 39 and Uchikawa et al 37 used MAS as a primary outcome measure, otherwise selection of outcome measures was variable between studies. The three case studies [42][43][44] did not report formal outcome measures and instead provided qualitative descriptions.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…Chemodenervation in spinal cord injury J Lui et al individuals with SCI have been reported in four level 4 pre-post studies [35][36][37][38] and six level 5 studies (5 case series/studies, [40][41][42][43][44] one retrospective chart review 39 ). Results from these studies are summarized in Table 3.…”
Section: Levels Of Evidence Bontmentioning
confidence: 99%
“…Nine studies investigated the use of BoNT, [26][27][28][29][30][31][32][33][34] and 10 studies investigated phenol/alcohol [35][36][37][38][39][40][41][42][43][44] for management of spasticity in SCI with chemodenervation. The literature search did not identify any randomized or non-RCTs looking at management of spasticity in a sample population with ⩾ 50% SCI participants, precluding the use of PEDro and Downs and Black Scale for quality assessment.…”
Section: Studiesmentioning
confidence: 99%
“…Results from these studies are summarized in Table 3. Seven [35][36][37][38][39]41,43 of the 10 studies involved phenol injections ranging from 0.3 to 10 ml and 5 to 6% concentration. Alcohol concentration used in three case series/studies 40,42,44 ranged from 68 to 100%, with volumes between 7.5 and 10 ml.…”
Study design: Systematic review. Objectives: To systematically review the literature on chemodenervation with botulinum toxin (BoNT) or phenol/alcohol for treatment of limb spasticity following spinal cord injury (SCI). Setting: British Columbia, Canada. Methods: EMBASE, MEDLINE, CINAHL, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched for English language studies published up until March 2014. Studies were assessed for eligibility and quality by two independent reviewers. Results: No controlled trials were identified. A total of 19 studies were included: 9 involving BoNT and 10 involving phenol/alcohol. Owing to the clinically diverse nature of the studies, meta-analysis was deemed inappropriate. The studies produced level 4 and level 5 evidence that chemodenervation with BoNT or alcohol/phenol can lead to improvement in outcome measurements classified in the body structure and function, as well as activity domains of the International Classification of Functioning, Disability and Health framework. The Modified Ashworth Scale (MAS) was the most commonly used outcome measure. All six studies on BoNT and three of the four studies on phenol/alcohol measuring MAS reported a decrease in at least one point. An improvement in MAS was not always associated with improvement in function. The effect of phenol/alcohol has the potential to last beyond 6 months; study follow-up did not occur beyond this time point. Conclusion Chemodenervation with BoNT or phenol/alcohol may improve spasticity and function in individuals with SCI. However, there is a lack of high-quality evidence and further research is needed to confirm the efficacy of these interventions.
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