Subretinal pressure and retinal adhesion

“…Two relevant subcases with simple analytic results arise. When the substrate tissue within the lesion is leaky and L c > 1 (for example, if the tight junctions of the RPE monolayer are locally disrupted), the blister radius in the weak adhesion limit ( * ≈ 0) is determined by equation (22) and is plotted in figure 6(a). In the case where the RPE pump flux is not affected by the inflamed tissue, the resulting quadratic equation can be solved to find the blister radius as a function of the dimensionless combination * (equation ( 21)) and Jp = J p /(L c P).…”

Section: Discussionmentioning

confidence: 99%

A mechanical model of retinal detachment

Chou¹,

Siegel

2012

Phys. Biol.

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We present a model of the mechanical and fluid forces associated with exudative retinal detachments where the retinal photoreceptor cells separate, typically from the underlying retinal pigment epithelium (RPE). By computing the total fluid volume flow arising from transretinal, vascular and RPE pump currents, we determine the conditions under which the subretinal fluid pressure exceeds the maximum yield stress holding the retina and RPE together, giving rise to an irreversible, extended retinal delamination. We also investigate localized, blister-like retinal detachments by balancing mechanical tension in the retina with both the retina-RPE adhesion energy and the hydraulic pressure jump across the retina. For detachments induced by traction forces, we find a critical radius beyond which the blister is unstable to growth. Growth of a detached blister can also be driven by inflamed lesions in which the tissue has a higher choroidal hydraulic conductivity, has insufficient RPE pump activity, or has defective adhesion bonds. We determine the parameter regimes in which the blister either becomes unstable to growth, remains stable and finite-sized, or shrinks, allowing possible healing. The corresponding stable blister radius and shape are calculated. Our analysis provides a quantitative description of the physical mechanisms involved in exudative retinal detachments and can help guide the development of retinal reattachment protocols or preventative procedures.

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“…I have also meddled in several other fields, among them : eye movement (20,158), experimental pathology (37,46,115), pain (72,74,102,106,123), tissue mechanics (90,108,122,140,144), myopia (39,60) physiological optics (5,16,69,75,114,147) and retinal detachment (59,101). Instrument design has been a continuing hobby and I believe I may have been the first to obtain passable images by confocal microscopy (69) and to use the technique to elucidate a biological problem (75).…”

Section: Publication Massmentioning

confidence: 99%

An Oneiropenic Account of an Ophthalmological Career

Maurice

1998

Experimental Eye Research

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Subretinal pressure and retinal adhesion

Cited by 29 publications

References 5 publications

Retinal Traction in Vivo and Postmortem

Retinal Traction in Vivo and Postmortem

A mechanical model of retinal detachment

An Oneiropenic Account of an Ophthalmological Career

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