Subretinal Drusenoid Deposits With Increased Autofluorescence in Eyes With Reticular Pseudodrusen

Lee, Mee Yon; Ham, Don-Il

doi:10.1097/iae.0b013e318295f701

Cited by 28 publications

(33 citation statements)

References 24 publications

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“…Nomenclature: In previous studies, the terms reticular pseudodrusen, pseudo-reticular drusen, or pseudodrusen was used for different en face modalities 2, 8, 15, 25–32 , and the term subretinal drusenoid deposits for cross-sectional histology and SD-OCT 6, 7, 32, 33 In the present article, we will use the term pseudodrusen for standard en face ophthalmoscopy (color fundus photography, infrared reflectance (IR), red-free (RF), and autofluorescence (AF)) and the term subretinal drusenoid deposits for the collections of material seen in the subretinal space in histologic specimens, AOSLO, and OCT.…”

Section: Methodsmentioning

confidence: 99%

“…30 It is recommended that detection should be confirmed using more than one modality for improving accuracy. 30, 31 The identification of pseudodrusen in our study was based on their presence in at least 2 en face imaging modalities and in SD-OCT. 27, 29, 32 In en face imaging, pseudodrusen appear as an interlacing collection of ribbons or a dot-like pattern of yellow-white lesions (in color fundus photography), a pattern of hypo-reflective or hyper-reflective spots (in IR reflectance), or a pattern of small hypo-autofluorescent areas against a background of mild hyper-autofluorescence (in AF). Although a reticular pattern was often seen in color photography, it was not a criterion for diagnosis.…”

Section: Methodsmentioning

confidence: 99%

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Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy

Zhang¹,

Wang²,

Rivero³

et al. 2014

American Journal of Ophthalmology

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Purpose To describe the microscopic structure of photoreceptors impacted by subretinal drusenoid deposits, also called pseudodrusen, an extracellular lesion associated with age-related macular degeneration (AMD), using adaptive optics scanning laser ophthalmoscopy (AOSLO). Design Observational case series. Methods Fifty-three patients with AMD and 10 age-similar subjects in normal retinal health were recruited. All subjects underwent color fundus photography, infrared reflectance, red-free reflectance, autofluorescence, and spectral-domain optical coherence tomography (SD-OCT). Subretinal drusenoid deposits were classified with a 3-stage OCT-based grading system. Lesions and surrounding photoreceptors were examined with AOSLO. Results Subretinal drusenoid deposits were found in 26 eyes of 13 patients with AMD and imaged by AOSLO and SD-OCT in 18 eyes (n=342 lesions). SD-OCT showed subretinal drusenoid deposits as highly reflective material accumulated internal to the retinal pigment epithelium. AOSLO revealed that photoreceptor reflectivity was qualitatively reduced by stage 1 subretinal drusenoid deposits and greatly reduced by stage 2. AOSLO presented a distinct structure in stage 3, a hyporeflective annulus consisting of deflected, degenerated or absent photoreceptors. A central core with a reflectivity superficially resembling photoreceptors is formed by the lesion material itself. A hyporeflective gap in the photoreceptor ellipsoid zone on either side of this core shown in SD-OCT corresponded to the hyporeflective annulus seen by AOSLO. Conclusions AOSLO and multimodal imaging of subretinal drusenoid deposits indicate solid, space filling lesions in the subretinal space. Associated retinal reflectivity changes are related to lesion stages and are consistent with perturbations to photoreceptors, as suggested by histology.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy

Zhang¹,

Wang²,

Rivero³

et al. 2014

American Journal of Ophthalmology

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“…The hypoautofluorescent nature of these lesions additionally suggests that they are not directly derived from photoreceptor outer segments as these would be highly autofluorescent due to abundant bisretinoid. Recently, Lee and Ham have identified a minority of RPD that display hyperautofluorescence, which suggests that these deposits additionally contain retinoid components either from the photoreceptor, or lipofuscin from the RPE (Lee and Ham, 2014). They conclude by suggesting that RPD may fall into at least two types, classical hypoautofluorescent RPD and a hyperautofluorescent variant (Lee and Ham, 2014).…”

Section: Fundus Autofluorescence Of Reticular Pseudodrusenmentioning

confidence: 99%

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Khan

Mahroo

Khan

et al. 2016

Progress in Retinal and Eye Research

172

159

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Drusen are discussed frequently in the context of their association with age-related macular degeneration (AMD). Some types may, however, be regarded as a normal consequence of ageing; others may be observed in young age groups. They also occur in a number of inherited disorders and some systemic conditions. Whilst drusen are classically located external (sclerad) to the retinal pigment epithelium, accumulations of material internal (vitread to) this layer can display a drusen-like appearance, having been variously termed pseudodrusen or subretinal drusenoid deposits. This review first briefly presents an overview of drusen biogenesis and subclinical deposit. The (frequently overlapping) subtypes of clinically detectable deposit, seen usually in the context of ageing or AMD, are then described in more detail, together with appearance on imaging modalities: these include hard and soft drusen, cuticular drusen, reticular pseudodrusen and "ghost drusen". Eye disorders other than AMD which may exhibit drusen or drusen-like features are subsequently discussed: these include monogenic conditions as well as conditions with undefined inheritance, the latter including some types of early onset drusen such as large colloid drusen. A number of systemic conditions in which drusen-like deposits may be seen are also considered. Throughout this review, high resolution images are presented for most of the conditions discussed, particularly the rarer ones, providing a useful reference library for images of the range of conditions associated with drusen-like appearances. In the final section, some common themes are highlighted, as well as a brief discussion of some future avenues for research.

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“…8,9 Among them, Suzuki et al 8 introduced a classification of reticular pseudodrusen into three different subtypes on the basis of morphologic features: dot pseudodrusen, ribbon pseudodrusen, and peripheral pseudodrusen. In their study, dot, ribbon, and peripheral pseudodrusen were found in 96.1%, 40.2%, and 5.7% of eyes with pseudodrusen, respectively.…”

mentioning

confidence: 99%

Prevalence of Subtypes of Reticular Pseudodrusen in Newly Diagnosed Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Korean Patients

Kim

Chang

Kim

et al. 2015

Retina

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Subretinal Drusenoid Deposits With Increased Autofluorescence in Eyes With Reticular Pseudodrusen

Abstract: Subretinal drusenoid deposits are not homogeneous and can be classified into two types according to the fundus autofluorescence. Multimodal imaging tests are needed for the differential diagnosis of subretinal drusenoid deposits.

Cited by 28 publications

References 24 publications

Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy

Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Prevalence of Subtypes of Reticular Pseudodrusen in Newly Diagnosed Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Korean Patients

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