Subretinal Abscess Due to<i>Nocardia farcinica</i>Resistant to Trimethoprim- Sulfamethoxazole in a Patient with Systemic Lupus Erythematosus

Dodds, Emilio M.; Echandi, Laura V.; Puente, Susana I.; Kaufman, Sara

doi:10.1080/09273940600760514

Cited by 17 publications

(7 citation statements)

References 3 publications

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“…Cases involving N. farcinica that is resistant to trimethoprim/sulfamethoxazole have been described previously [5,12]. Chronic lung colonization in our patient, which was demonstrated by his positive PCR assay, indicates that antibiotic treatment does efficiently and completely eradicate the bacterium.…”

Section: Discussionsupporting

confidence: 53%

Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report

Bittar

Stremler

Audie³

et al. 2010

J Med Case Reports

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IntroductionRespiratory tract infections are the major causes of morbidity and mortality in patients with cystic fibrosis. Nocardia are rarely implicated in these infections and few reports of the involvement of this species are found in the literature.Case presentationWe describe a case of lung infection followed by chronic colonization of trimethoprim and sulfamethoxazole resistant Nocardia farcinica in a patient with cystic fibrosis. The chronic colonization of this uncommon bacterium in patients with cystic fibrosis was proved using a newly developed real-time polymerase chain reaction assay, which indicates that this bacterium, despite treatment, is difficult to eradicate.ConclusionOur case report confirms that this organism can be recovered in persons with cystic fibrosis. Its eradication is necessary especially if the patient is to undergo lung transplantation.

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Section: Discussionsupporting

confidence: 53%

Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report

Bittar

Stremler

Audie³

et al. 2010

J Med Case Reports

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“…However, side effects such as skin reactions may necessitate alternative therapy [6,24,36]. In addition, as many as 50% of isolates demonstrate TMP-SMX resistance, emphasizing the need for antibiotic susceptibility testing of clinical isolates [13,37,38]. N. farcinica is susceptible to TMP-SMX, minocycline, linezolid, moxifloxacin, and amikacin and demonstrates variable susceptible to imipenem-cilastatin and ciprofloxacin [20,[39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

DisseminatedNocardia farcinica: Literature Review and Fatal Outcome in an Immunocompetent Patient

Budzik

Hosseini

Mackinnon

et al. 2012

Surgical Infections

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“…There have been no reports of amikacin resistance in Nocardia farcinica [ 1 , 2 , 11 , 12 , 19 , 21 , 22 ]. There have been a few reported cases in the general medical literature of Nocardia farcinica resistance to co-trimoxazole [ 4 , 10 , 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

The role of oral co-trimoxazole in treating Nocardia farcinica keratitis—a case report

Sharma

O’Hagan

2016

J Ophthal Inflamm Infect

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Background Nocardia farcinica is one of the more recently identified species of the Nocardia genus. Nocardia farcinica keratitis is a rare occurrence, with only eight previously reported cases. Semi-permeable rigid contact lens use was associated with one of these reported cases. We report the first case of extended wear soft contact-lens-related Nocardia farcinica keratitis and recommend a new treatment regime.FindingsA 47-year-old lady presented with a right eye keratitis after wearing her extended wear soft contact lenses for five continuous weeks. There was no history of trauma or swimming with contact lenses in. Empirical ciprofloxacin and tobramycin eye drops were not tolerated due to ocular surface irritation on application; and instead, empirical treatment was with chloramphenicol and fortified gentamicin 1.5 % eye drops. Corneal scrapings grew Nocardia farcinica after 3 weeks—sensitive to amikacin and co-trimoxazole. Treatment was changed to amikacin 2.5 % eye drops, resulting in partial resolution of the corneal infiltrates. Oral co-trimoxazole 160/800 mg BD was added, due to cultured drug sensitivity and its high ocular penetration, with good results and a final right eye best-corrected visual acuity of 6/5.Conclusion Nocardia farcinica keratitis should be considered in the differential diagnosis of contact-lens-related keratitis. We report the first case occurring in association with extended wear soft contact lenses. Nocardia species can mimic fungal and Acanthamoeba keratitis. Treatment with oral co-trimoxazole has not been previously reported. This case demonstrates a role for co-trimoxazole in treating Nocardia farcinica keratitis based on cultured drug sensitivities.

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Subretinal Abscess Due toNocardia farcinicaResistant to Trimethoprim- Sulfamethoxazole in a Patient with Systemic Lupus Erythematosus

Abstract: In an immunocompromised patient with pulmonary involvement and a subretinal abscess with a characteristic aspect, one should consider nocardia as a possible etiology taking into account its possible antibiotic resistances.

Cited by 17 publications

References 3 publications

Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report

Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report

DisseminatedNocardia farcinica: Literature Review and Fatal Outcome in an Immunocompetent Patient

The role of oral co-trimoxazole in treating Nocardia farcinica keratitis—a case report

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