Subperiosteal hydroxyapatite implants in rats submitted to ethanol ingestion

Camilli, José Ângelo; Cunha, Marcelo Rodrigues da; Bertran, Celso Aparecido; Kawachi, Elizabete Yoshie

doi:10.1016/j.archoralbio.2004.02.009

Cited by 26 publications

(28 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a consequence, most studies in the literature testing biomaterials have used rat femur and tibia because of their good biomechanical capacity and endochondral origin, which are important for the osteogenic function of bone. The osseointegration of an implant depends on factors such as embryonic origin, maturation, contact with the implant, physical and chemical characteristics of biomembranes, presence of soft tissue at the bone-implant interface, and the health of the bone tissue [6,12,31]. Thus, these factors may have contributed to the amount of new bone formed in the surgical area during the experimental period not being sufficient to completely close the bone defect.…”

Section: Discussionmentioning

confidence: 95%

“…The possibilities of structural modifications of these membranes are an advantage compared to some marketed biomaterials. However, the bone health status is essential to permit the osseointegration of biomaterials and to obtain satisfactory results [6,12]. In this respect, some factors such as low calcium ingestion, smoking, alcoholism, physical inactivity, and hormonerelated disorders due to gonadal hormone deficiency can compromise the success of implants [6,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats

Hirata

Munhoz

Plepis

et al. 2015

Injury

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats

Hirata

Munhoz

Plepis

et al. 2015

Injury

View full text Add to dashboard Cite

“…The protocol used in the present study was satisfactory to cause bone alterations, and this it did not cause overdose or death of any animal. Previous studies about experimental alcoholism used ethanol concentration ranging between 10 and 30%, in time periods of four to twelve weeks (Horvath et al, 2010;Soares et al, 2010;Camilli et al, 2004). In bone tissue, as well as in other tissues, alcohol concentration is low, but the modifications occur as the exposure time is prolonged (Yttri et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs

et al. 2015

View full text Add to dashboard Cite

The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179±2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC -UNIFENAS.Keywords: ethanol, rats, bone, alcoholism, detoxification. Efeitos do consumo de etanol e da desintoxicação alcóolica sobre a biomecânica e morfologia óssea em fêmur de ratosResumo O objetivo deste estudo foi verificar os efeitos do consumo de etanol e da desintoxicação alcoólica sobre a biomecânica, área e espessura do osso cortical e trabecular em fêmur de ratos. Este foi um estudo experimental no qual foram utilizados 18 ratos Wistar machos, com 40 dias de vida, pesando 179±2,5 g. Os ratos foram divididos em três grupos (n=06): CT (controle), AC (alcoolista crônico), e DT (desintoxicado). Após os procedimentos experimentais os animais foram eutanaziados por uma overdose de anestésico e os fêmures coletados para os testes mecânicos e processamento histológico. Todos os animais não apresentaram desnutrição ou desidratação durante o período de experimentação.As análises morfométrica do osso cortical e trabecular demonstraram que os animais do grupo AC apresentavam dimensões inferiores, enquanto nos animais do grupo DT observou-se um aumento na área e espessura do osso cortical e trabecular. Dados dos materiais e das propriedades estruturais óssea do grupo AC destacam os efeitos nocivos do etanol sobre as propriedades mecânicas do osso. Os resultados deste estudo demonstraram que os ratos do grupo AC apresentaram danos significativos no osso em todas as variáveis analisadas. Esses resultados sugerem que a desintoxicação alcoólica é recomendada no planejamento pré-operatório e isso corrobora para o sucesso de cirurgias e reparação no tecido ósseo. Agradecemos ao apoio financeiro oferecido pelo PROBIC -UNIFENAS.Palavras-chave: etanol, rat...

show abstract

“…Bien que les mécanismes par lesquels ses effets sur le métabolisme osseux et la balance entre résorption et apposition autour d' un implant (quel qu' il soit) ne soient pas complètement élucidés [43], on sait que sa consommation est associée à des déficiences du système immunitaire qui perturbent le remaniement des tissus osseux péri-implantaires, mettant en péril l' ostéo-intégration [44,45] et favorisant la péri-implantite [46].…”

Section: Sur L' Osunclassified