Submucosal, oropharyngeal heterotopia of parathyroid

Triantafyllou, Asterios

doi:10.1111/ors.12014

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…Hamilton and Mossman, noted that aberrations in the downward migration of the thyroglossal duct during development may result in heterotopic, for instance high cervical, thyroid tissue [24] and the complex events occurring during development of human neck [2, 24] could affect spatial relations. Derivatives of the paired and laterally positioned, fourth pharyngeal pouches (ultimobranchial tissue) also contribute to thyroid development [1, 4], whereas heterotopic, parathyroid derivatives of the third pharyngeal pouches can be found even in the oropharynx [26]. Aberrations during the embryonic outgrowth of the pharyngeal pouch endoderm would account for heterotopic thyroid in cervical lymph nodes, but the extent of the lateral contributions to the development of human thyroid is not established and their morphology may not correspond with that of conventional follicles.…”

Section: The Controversy Over Nodal Thyroid Inclusions: Theoretical mentioning

confidence: 99%

Incidental findings of thyroid tissue in cervical lymph nodes: old controversy not yet resolved?

Triantafyllou

Williams

Angelos

et al. 2015

Eur Arch Otorhinolaryngol

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The clinical significance of papillary or follicular thyroid tissue incidentally discovered in cervical lymph nodes during pathological assessment of neck dissections for non-thyroid cancers of the upper aero-digestive tract is critically reviewed. Special emphasis is given to controversies over normal-looking, nodal, thyroid follicles. Arguments for and against the benign nature of these follicles are considered together with processes that could be involved in their formation. The admittedly limited evidence suggests that benign, thyroid follicular inclusions rarely occur in cervical lymph nodes. Histological criteria that could be helpful in recognising the inclusions, which include assessing their extent in conjunction with the size of the node, are discussed. Finally, an algorithm based on collaboration between specialists, correlating histological findings with imaging and loco-regional control of the upper aero-digestive tract cancer, is suggested for the management of patients with incidentally discovered, nodal thyroid tissue.

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Section: The Controversy Over Nodal Thyroid Inclusions: Theoretical mentioning

confidence: 99%