Submucosal Exploration of EMG and Physiological Parameters in the Bladder Wall

Brancato, Luigi; Weydts, Tristan; Soebadi, Mohammad Ayodhia; Ridder, Dirk De; Puers, Robert

doi:10.3390/proceedings1040605

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…The Microchip Technology PIC12LF1552 controller is selected for its small size. Full details on the fabrication and design of the sensor and supporting unit have been published 14,15 …”

Section: Methodsmentioning

confidence: 99%

Novel implantable pressure and acceleration sensor for bladder monitoring

et al. 2020

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Objectives: To test the hypothesis that an implantable sensing system containing accelerometers can detect small-scale autonomous movements, also termed micromotions, which might be relevant to bladder physiology. Methods: We developed a 6-mm submucosal implant containing a pressure sensor (MS5637) and a triaxial accelerometer (BMA280). Sensor prototypes were tested by implantation in the bladders of Gottingen minipigs. Repeated awake voiding cystometry was carried out with air-charged catheters in a standard urodynamic set-up as comparators. We identified four phases of voiding similar to cystometry in other animal models based on submucosal pressure. Acceleration signals were separated by frequency characteristics to isolate linear acceleration from the baseline acceleration. The total linear acceleration was calculated by the root mean square of the three measurement axes. Acceleration activity during voiding was investigated to adjacent 1-s windows and was compared with the registered pressure. Results: We observed a total of 19 consecutive voids in five measurement sessions. A good correlation (r > 0.75) was observed between submucosal and catheter pressure in 14 of 19 premicturition traces. The peak-to-peak interval between maximum total linear acceleration was correlated with the interval between submucosal voiding pressure peaks (r = 0.760, P < 0.001). The total linear acceleration was higher during voiding compared with pre-and postmicturition periods (start of voiding/phase 1). Conclusions: To the best of our knowledge, this is the first report of bladder wall acceleration, a novel metric that reflects bladder wall movement. Submucosal sensors containing accelerometers can measure bladder pressure and acceleration.

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“…The Microchip Technology PIC12LF1552 controller is selected for its small size. Full details on the fabrication and design of the sensor and supporting unit have been published 14,15 …”

Section: Methodsmentioning

confidence: 99%

Novel implantable pressure and acceleration sensor for bladder monitoring

et al. 2020

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“…A resolution of 0.1 mbar is sufficient to measure any pressure variations in classical cystometry. Although the use of an EMG system has been shown to provide interesting results concerning bladder contractions [7] and can be made implantable, , the choice was made to limit the system to inertial and pressure measurements in order to avoid biocompatibility as well as noise problems.…”

Section: Description Of the Devicementioning

confidence: 99%

A novel method to investigate bladder wall behavior by acceleration and pressure sensing

Weydts

Brancato

Soebadi

et al. 2018

Sensors and Actuators A: Physical

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Bladder dysfunctions form a continuously growing problem as the ageing population in our society is steadily increasing. However, scientific knowledge about the fundamental principles underlying bladder diseases is still lacking. Conventional cystometry-based methods for assessing bladder function are quite limited in their scope. In this paper, a novel device is introduced to research the bladder. An exploratory device was designed for measuring bladder wall contractions in rats using accelerometers. Later, a fully implantable system was created to extend the measurements to larger animal models. The batterypowered implant provides a wireless readout of multiple sensors with synchronous visualization. An intelligent algorithm is used to optimize the power consumption and to extend the autonomy after implantation, yielding a useable measurement time of 16 continuous days and several months of standby-time.

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“…For this reason, Parylene-C has been widely used for the encapsulation of implantable devices [7,8,9,10,11]. There are, however, reports of progressive degradation of the polymer insulation barrier properties when it is exposed to saline solution in a body-mimicking environment [12,13].…”

Section: Introductionmentioning

confidence: 99%

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

et al. 2018

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This paper investigates the effects on the blood compatibility of surface nanostructuring of Parylene-C coating. The proposed technique, based on the consecutive use of O2 and SF6 plasma, alters the surface roughness and enhances the intrinsic hydrophobicity of Parylene-C. The degree of hydrophobicity of the prepared surface can be precisely controlled by opportunely adjusting the plasma exposure times. Static contact angle measurements, performed on treated Parylene-C, showed a maximum contact angle of 158°. The nanostructured Parylene-C retained its hydrophobicity up to 45 days, when stored in a dry environment. Storing the samples in a body-mimicking solution caused the contact angle to progressively decrease. However, at the end of the measurement, the plasma treated surfaces still exhibited a higher hydrophobicity than the untreated counterparts. The proposed treatment improved the performance of the polymer as a water diffusion barrier in a body simulating environment. Modifying the nanotopography of the polymer influences the adsorption of different blood plasma proteins. The adsorption of albumin—a platelet adhesion inhibitor—and of fibrinogen—a platelet adhesion promoter—was studied by fluorescence microscopy. The adsorption capacity increased monotonically with increasing hydrophobicity for both studied proteins. The effect on albumin adsorption was considerably higher than on fibrinogen. Study of the proteins simultaneous adsorption showed that the albumin to fibrinogen adsorbed ratio increases with substrate hydrophobicity, suggesting lower thrombogenicity of the nanostructured surfaces. Animal experiments proved that the treated surfaces did not trigger any blood clot or thrombus formation when directly exposed to the arterial blood flow. The findings above, together with the exceptional mechanical and insulation properties of Parylene-C, support its use for packaging implants chronically exposed to the blood flow.

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Submucosal Exploration of EMG and Physiological Parameters in the Bladder Wall

Cited by 5 publications

References 6 publications

Novel implantable pressure and acceleration sensor for bladder monitoring

Novel implantable pressure and acceleration sensor for bladder monitoring

A novel method to investigate bladder wall behavior by acceleration and pressure sensing

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

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