Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing

Kim, Heejin; Min, Kyoung‐Ik; Inoue, Keita; Im, Do Jin; Kim, Dong Pyo; Yoshida, Jun

doi:10.1126/science.aaf1389

Cited by 228 publications

(145 citation statements)

References 33 publications

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“…

and fine chemical industries. [7][8][9][10][11] Fused silica is one of the widely used substrates for the microfluidic technology in laboratory research and industrial applications due to its high melting point, high chemical stability, low thermal expansion coefficient, wide transmission spectral range, and good biocompatibility. In particular, extension of the microfluidic networks from widely used 2D to 3D configurations has now been considered as a promising scheme to enhance the performance of manipulation of fluids such as high-efficiency mixing, separation, and detection.

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mentioning

confidence: 99%

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Lin

Song

et al. 2020

Adv Materials Technologies

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and fine chemical industries. [1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology. In particular, extension of the microfluidic networks from widely used 2D to 3D configurations has now been considered as a promising scheme to enhance the performance of manipulation of fluids such as high-efficiency mixing, separation, and detection. [7][8][9][10][11] Fused silica is one of the widely used substrates for the microfluidic technology in laboratory research and industrial applications due to its high melting point, high chemical stability, low thermal expansion coefficient, wide transmission spectral range, and good biocompatibility. However, fabrication of freeform 3D hollow microchannels in fused silica is still difficult for current 2D fabrication techniques in terms of complex and tedious fabrication procedures, additional costs for aligning, stacking, and bonding steps. [12][13][14] Currently, one of the most representative 3D microfabrication techniques of fused silica is ultrashort pulse laser microfabrication. [15][16][17][18][19][20] A suspended hollow microchannel structure with a 3D controllable configuration can be fabricated in a way of either laser-assisted selective wet etching [21][22][23] or liquid-assisted laser ablation. [24][25][26] In addition, suspended hollow structures with 3D shapes and a high precision in fused silica can be fabricated by combining room-temperature casting and sacrificial template replication. [27] Meanwhile, 3D printing of glass materials emerging in recent years brings some new opportunities for scalable fabrication of freeform glass structures by either additive manufacturing strategies [28][29][30][31][32][33] or laser subtractive processing methods. [34][35][36] However, controllable formation of freeform hollow microchannel with arbitrary length encapsulated in 3D printed glass structures has not yet been demonstrated, which is highly desirable for high-infidelity manufacturing of artificial organs, on-chip construction of biomimetic microenvironments, [37][38][39][40][41] as well as enrichment of the functions of continuous-flow microreactors (e.g., seamless integration of customized functional module for temperature control and on-line spectrometer monitoring). [42,43] Especially, simultaneous fabrication of 3D embedded hollow microchannels with high aspect ratios and centimeter-scale glass objects with external arbitrary shapes on/in a single substrate still Large-scale microfluidic microsystems with complex 3D configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative applications such as organ-on-a-chip as well as continuous-flow manufacturing. However, freeform fabrication of such systems remains challenging for current fabrication techniques in terms of fabrication resolution, flexibility, and achievable foo...

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confidence: 99%

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Lin

Song

et al. 2020

Adv Materials Technologies

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“…Yoshida and Kim recently provided an astonishing example on the potential of flash chemistry in controlling fast isomerization of organolithiums [48]. The authors designed a chip microreactor (CMR), able to deliver a reaction time in the range of submilliseconds (0.33 ms) under cryogenic conditions.…”

Section: Reviewmentioning

confidence: 99%

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

Fanelli¹,

Parisi²,

Degennaro³

et al. 2017

Beilstein J. Org. Chem.

177

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Microreactor technology and flow chemistry could play an important role in the development of green and sustainable synthetic processes. In this review, some recent relevant examples in the field of flash chemistry, catalysis, hazardous chemistry and continuous flow processing are described. Selected examples highlight the role that flow chemistry could play in the near future for a sustainable development.

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“…With environmental concerns and health issues mounting, the next logical step is miniaturization of chemical reactions. [17][18][19] Heterogeneous reactions can run more efficiently in microfluidic format due to the large surface-tovolume ratios that ensure improved phase contact and heating is much easier controllable on the microscale which significantly enhances the yield of temperature-sensitive reactions. Although microreactor technology is a field which has seen significant scientific interest over the years, application demonstration has mostly been limited by the lack of suitable materials for chemical applications.…”

Section: Introductionmentioning

confidence: 99%

High‐Performance Materials for 3D Printing in Chemical Synthesis Applications

et al. 2019

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3D printing has emerged as an enabling technology for miniaturization. High‐precision printing techniques such as stereolithography are capable of printing microreactors and lab‐on‐a‐chip devices for efficient parallelization of biological and biochemical reactions under reduced uptake of reactants. In the world of chemistry, however, up until now, miniaturization has played a minor role. The chemical and thermal stability of regular 3D printing resins is insufficient for sustaining the harsh conditions of chemical reactions. Novel material formulations that produce highly stable 3D‐printed chips are highly sought for bringing chemistry up‐to‐date on the development of miniaturization. In this work, a brief review of recent developments in highly stable materials for 3D printing is given. This work focuses on three highly stable 3D‐printable material systems: transparent silicate glasses, ceramics, and fluorinated polymers. It is further demonstrated that 3D printing is also a versatile technique for surface structuring of polymers to enhance their wetting performance. Such micro/nanostructuring is key to selectively wetting surface patterns that are versatile for chemical arrays and droplet synthesis.

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Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing

Cited by 228 publications

References 33 publications

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

High‐Performance Materials for 3D Printing in Chemical Synthesis Applications

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