Submicroscopic structure of Drosophila hydei salivary gland cells

Berendes, H. D.; Bruyn, W. C. De

doi:10.1007/bf00321012

Cited by 23 publications

(2 citation statements)

References 12 publications

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“…Histochemical studies on the t[ature of the secretory product were undertaken by Lesher (5) who employed the periodic acid-Schiff reaction for localization of mucoprotein. Several excellent studies on the ultrastructure of the salivary gland cells of the Drosophila larva are available (6,7), and the secretory inclusions in the salivary gland cells of Drosophila hydei have been described as inhomogeneous in structure (8). Therefore, the present report is limited to observations on the ultrastructure of the secretory inclusions in the salivary gland cells of D. melanogaster where they occur as highly organized, clearly patterned structures.…”

Section: Figurementioning

confidence: 95%

ULTRASTRUCTURE OF THE SECRETORY INCLUSIONS OF THE SALIVARY GLAND CELL IN DROSOPHILA

Rizki

1967

The Journal of Cell Biology

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Section: Figurementioning

confidence: 95%

ULTRASTRUCTURE OF THE SECRETORY INCLUSIONS OF THE SALIVARY GLAND CELL IN DROSOPHILA

Rizki

1967

The Journal of Cell Biology

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“…However, it is clear from the early literature that first saw these structures that capes are one of a number of related structures all containing 'oval bodies' (i.e. RNP) where the INM and ONM may both bleb outwards from the nuclear envelope, or occasionally go in different directions 41 and the relative prevalence of these forms may depend on the species studied 21,25,[41][42][43][44] . While our previous serial block face imaging showed that the double invagination of the capes have been predominant in our samples 19 , we do see outward blebs in some cases (arrowhead in Fig 5D).…”

Section: Resultsmentioning

confidence: 99%

TheDrosophilaEGFR ligand mSpitz is delivered to cytoplasmic capes at sites of non-canonical RNA export on the nuclear envelopeviathe endosomal system

Mattie

Kumar²,

Travor

et al. 2020

Preprint

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Nuclear-cytoplasmic communication is not limited to nuclear pores, with both proteins and RNA using alternative routes between these compartments. We previously characterized cytoplasmic capes (large invaginations of the nuclear envelope in Drosophila), which are enriched for the membrane-bound EGF receptor ligand mSpitz, endosome-related organelles and ubiquitylated proteins. Closely associated with capes are groups of perinuclear vesicles resembling those seen at sites of RNP export via a budding mechanism. Here, we demonstrate that mSpitz delivery to capes requires passage through the endosomal system. We also show that capes are closely associated with sites of non-canonical RNP export as well as the dFrizzled2 receptor C terminal fragment, a core component of this export pathway. Video microscopy of glands in intact larvae indicates that cytoplasmic capes are stable structures that persist for at least 90 minutes without conspicuous growth. We further show that capes appear with the growth of the salivary gland rather than its developmental stage. Finally, we show that the large F-actin binding protein βH-spectrin, which modulates endosomal trafficking, as well as its partner βH-spectrin are required for cape formation. Cytoplasmic capes therefore represent a subspecialization of the nuclear envelope where endosomal trafficking and RNP export are closely associated.

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Activities of the nuclear envelope in the salivary glands of Drosophila

Thomopoulos

Kastritsis

1983

Cell Tissue Res.

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Morphological data are presented concerning the single-membrane-bound vesicles ("oval bodies") associated with the nuclear envelopes of larval salivary gland cells of Drosophila. Data are also presented concerning the existence of cytoplasmic annulate lamellae in these same cells. The mode of formation of these structures, as well as the relationships between them and with other cytoplasmic organelles are described. The possible functional significance of these phenomena is discussed.

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Submicroscopic structure of Drosophila hydei salivary gland cells

Cited by 23 publications

References 12 publications

ULTRASTRUCTURE OF THE SECRETORY INCLUSIONS OF THE SALIVARY GLAND CELL IN DROSOPHILA

ULTRASTRUCTURE OF THE SECRETORY INCLUSIONS OF THE SALIVARY GLAND CELL IN DROSOPHILA

TheDrosophilaEGFR ligand mSpitz is delivered to cytoplasmic capes at sites of non-canonical RNA export on the nuclear envelopeviathe endosomal system

Activities of the nuclear envelope in the salivary glands of Drosophila

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