2015
DOI: 10.1002/smll.201502883
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Submicrometer-Sized Thermometer Particles Exploiting Selective Nucleic Acid Stability

Abstract: Encapsulated nucleic acid selective damage quantification by real-time polymerase chain reaction is used as sensing mechanism to build a novel class of submicrometer size thermometer. Thanks to the high thermal and chemical stability, and the capability of storing the read accumulated thermal history, the sensor overcomes some of current limitations in small scale thermometry.

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Cited by 21 publications
(10 citation statements)
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References 30 publications
(33 reference statements)
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“…On the other hand, optical thermometry has been studied by various researchers in different host materials. [1][2][3][4][49][50][51][52] The UCbased FIR is a versatile technique in the eld of optical thermometry to realize a slight change in the temperature of the desired system without any contact. 14 The UC emission intensity of the TCLs is also affected by changing the external temperature of the phosphor.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, optical thermometry has been studied by various researchers in different host materials. [1][2][3][4][49][50][51][52] The UCbased FIR is a versatile technique in the eld of optical thermometry to realize a slight change in the temperature of the desired system without any contact. 14 The UC emission intensity of the TCLs is also affected by changing the external temperature of the phosphor.…”
Section: Introductionmentioning
confidence: 99%
“…Concentration correction can then be applied to distinguish blending of material from DNA decay. Finally, understanding DNA length‐dependent kinetics may enable designing a DNA‐based thermometer, where the rate of DNA degradation can be related to the temperature or light that the DNA has been exposed to, in analogy to the DNA/RNA construct proposed by Puddu et al…”
Section: Resultsmentioning
confidence: 99%
“…Compared with conventional methods of temperature measurements, optical thermometry can realize a spatial distribution of temperature with sub‐micrometer resolution. Meanwhile, optical thermometry also owns merits such as rapid response, non‐contact, strong anti‐jamming capability and so on . At present, the research hotspot about optical thermometry mainly focuses on fluorescence intensity ratio (FIR) technology utilizing pairs of thermally coupled energy levels in rare‐earth ions .…”
Section: Introductionmentioning
confidence: 99%
“…Meanwhile, optical thermometry also owns merits such as rapid response, non-contact, strong anti-jamming capability and so on. [7][8][9][10][11][12][13][14][15] At present, the research hotspot about optical thermometry mainly focuses on fluorescence intensity ratio (FIR) technology utilizing pairs of thermally coupled energy levels in rare-earth ions. [16][17][18][19] More specifically, the two thermally coupled energy levels used in FIR technology are closely separated, so the upper level can be populated from the lower level by a thermal excitation process at higher temperature.…”
Section: Introductionmentioning
confidence: 99%