Submandibular glands as organs of synthesis and accumulation of insulin-like protein

Shubnikova, E. A.; Volkova, Elena F.; Printseva, O. Yu.

doi:10.1016/s0065-1281(84)80003-3

Cited by 19 publications

(13 citation statements)

References 7 publications

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“…The origin of immunoreactive insulin in saliva is of interest. Both immunoreactive insulin and insulin mRNA have been found in the salivary glands of mice (Kerr et al 1995) and rats (Taouis et al 1995), and immunoreactive insulin secretion from mouse salivary glands is sensitive to changes in glucose concentrations (Shubnikova et al 1984). It is therefore possible that the insulin found in saliva could be the product of local synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…Human saliva contains a proline-rich salivary peptide P-C, which potentiates glucose-induced insulin release and inhibits arginine-induced glucagon release in the rat pancreas (Kimura et al 1995, Kimura et al 1998. Insulin-like immunoreactivity has been extensively reported in rodent salivary glands, human parotid (Murakami et al 1982) and submandibular salivary glands (Shubnikova et al 1984), and in human saliva (Fekete et al 1993). Glucagon-like immunoreactivity has been reported in rat salivary glands (Lawrence et al 1977).…”

Section: Introductionmentioning

confidence: 99%

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Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals

Messenger¹,

Clifford²,

Morgan³

2003

Journal of Endocrinology

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Gastrointestinal peptides, including insulin, glucagon and glucose-dependent insulinotropic polypeptide (GIP) have previously been reported in salivary glands. Recent evidence has suggested they might influence postprandial macronutrient metabolism. This study therefore investigated and compared postprandial hormone concentrations in saliva and plasma to determine whether their secretion was influenced by oral food stimuli. In a within-subject randomised cross-over comparison of hormone concentrations in plasma and saliva following a mixed meal, 12 subjects were given two 1708 kJ mixed meals. On one occasion the meal was chewed and swallowed (swallowed meal), on the other it was chewed and expectorated (sham-fed meal). Salivary and plasma levels of immunoreactive insulin, GIP and glucagon-like peptide-1 (GLP-1), total protein, -amylase, glucose and nonesterified fatty acid were measured before and for 90 min following the meals. Saliva total protein and -amylase rose following both meals, indicating that the stimulus for salivary protein release is related to the presence of food in the mouth. GLP-1 was not detected in saliva. Fasting salivary insulin levels were lower in saliva than plasma (28 6 vs 40 25 pmol/l respectively). Both increased following the swallowed meal but the rise in saliva was slower and less marked than in plasma (peak levels 96 18 and 270 66 pmol/l for saliva and plasma respectively, P<0·01). Both were unchanged following the sham-fed meal. GIP was detected in saliva. Fasting GIP levels were significantly higher in saliva than plasma (183 23 compared with 20 7 pmol/l, P<0·01). They decreased in saliva following both swallowed and sham-fed meals to nadirs of 117 17 and 71 12 pmol/l respectively, but rose following the swallowed meal to peak levels of 268 66 pmol/l. These findings are consistent with insulin in saliva being an ultrafiltrate of that circulating in blood, but GIP in saliva being the product of local salivary gland synthesis, whose secretion is influenced, directly or indirectly, by oral stimuli. The function of salivary GIP is unknown, but we speculate that it may play a role in the regulation of gastric acid secretion in the fasting state.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals

Messenger¹,

Clifford²,

Morgan³

2003

Journal of Endocrinology

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“…The hormone insulin, produced by pancreatic b-cells of the islets of Langerhans, is the main hormone controlling carbohydrate and lipid metabolism. Insulin-like immunoreactivity has been extensively reported in rodent SGs, human parotid (Murakami et al, 1982) and submandibular SGs (Shubnikova et al, 1984), and in human saliva (Marchetti et al, 1986(Marchetti et al, , 1990Fekete et al, 1993). Fasting salivary insulin levels are lower in saliva than plasma, both increased following FI but the rise in saliva was slower and less marked than in plasma (Messenger et al, 2003).…”

Section: Insulinmentioning

confidence: 99%

Metabolic hormones in saliva: origins and functions

Zolotukhin

2012

Oral Diseases

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The salivary proteome consists of thousands of proteins, which include, among others, hormonal modulators of energy intake and output. Although the functions of this prominent category of hormones in whole body energy metabolism are well characterized, their functions in the oral cavity, whether as a salivary component, or when expressed in taste cells, are less studied and poorly understood. The respective receptors for the majority of salivary metabolic hormones have been also shown to be expressed in salivary glands, taste cells, or other cells in the oral mucosa. This review provides a comprehensive account of the gastrointestinal hormones, adipokines, and neuropeptides identified in saliva, salivary glands, or lingual epithelium, as well as their respective cognate receptors expressed in the oral cavity. Surprisingly, few functions are assigned to salivary metabolic hormones, and these functions are mostly associated with the modulation of taste perception. Because of the well-characterized correlation between impaired oral nutrient sensing and increased energy intake and body mass index, a conceptually provocative point of view is introduced, whereupon it is argued that targeted changes in the composition of saliva could affect whole body metabolism in response to the activation of cognate receptors expressed locally in the oral mucosa.

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“…The presence of an insulin-like material has been demonstrated in parotid and submandibular glands (10,11). These findings indicate a close endocrine relationship between the salivary glands and the pancreas.…”

mentioning

confidence: 75%

The Essential Amino Acid Domains in Salivary Peptide P-C That Potentiate Glucose-Induced Insulin Release and Inhibit Arginine-Induced Glucagon Release from Perfused Rat Pancreas

Kimura

Nakashima

Kimura

1995

Japanese Journal of Pharmacology

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ABSTRACT-The amino acid domains in salivary peptide P-C (1-44 peptide fragments, P-C) that are essential to potentiate insulin release and inhibit glucagon release were investigated using isolated perfused rat pancreas. P-C significantly potentiated not only glucose (8.3 mM)-induced insulin release, but also arginine (10 mM)-induced insulin release. The essential domain responsible for potentiation of insulin release was the P-C-(23-29) fragment, 23KPQGPPP29, while that inhibiting glucagon release was the P-C-(12-18) fragment, 12HQQGPPP18. Since both domains share a common fragment, QGPP, these findings indicate that the functional amino acid sequences KP and HQ may potentiate insulin release and inhibit glucagon release, respectively.

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Submandibular glands as organs of synthesis and accumulation of insulin-like protein

Cited by 19 publications

References 7 publications

Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals

Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals

Metabolic hormones in saliva: origins and functions

The Essential Amino Acid Domains in Salivary Peptide P-C That Potentiate Glucose-Induced Insulin Release and Inhibit Arginine-Induced Glucagon Release from Perfused Rat Pancreas

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