Sublingual protein delivery by a mucoadhesive patch made of natural polymers

Paris, Anne-Lise; Caridade, Sofia G.; Colomb, Evelyne; Bellina, Mélanie; Boucard, Eléa; Verrier, Bernard; Monge, Claire

doi:10.1016/j.actbio.2021.04.024

Cited by 17 publications

(17 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LbL film with the CS surface has been shown to provide mucoadhesion. , The novelty of this work was to decorate folic acid ligand on the LbL film to selectively bind the film to colon cancer. The adhesion between the LbL film and the cancer tissue was strengthened by decorating folic acid. , The receptor-mediated ligand binding would have a detachment strength of 0.90 ± 0.07 N/cm 2 .…”

Section: Discussionmentioning

confidence: 99%

Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer

Janardhanam

Bandi

Venuganti

2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The aim of the study was to develop and evaluate the efficacy of a functionalized layer-by-layer (LbL) assembled film entrapped with oxaliplatin (OX) and signal transducer and activator of transcription 3 (STAT3) siRNA in the localized treatment of colon cancer. The LbL film was prepared by the sequential layering of chitosan (CS) and alginate to attain desired physical and mechanical properties. The film was functionalized by coating folic acid-conjugated CS on one side. On the other side, polycaprolactone was coated as a backing layer to provide directional drug release. OX was entrapped within the layers of the film, while STAT3 siRNA was complexed with CS to form nanoparticles before entrapment in the LbL film. The CS–siRNA nanoparticles were taken up by the colon carcinoma, Caco-2 cells within 3 h and provided concentration-dependent reduction in STAT3 protein expression. The functionalized LbL film (F-LbL film) selectively adhered to the colon cancer tissue in the mice model, whereas the nonfunctionalized film adhered to the normal colon tissue. The combination of OX and STAT3 siRNA provided significantly greater tumor regression, survival rate, and STAT3 protein suppression after localized delivery through oral administration compared with intravenous administration. Taken together, the F-LbL film can selectively bind to colon tumors for localized delivery of drugs to treat colon cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer

Janardhanam

Bandi

Venuganti

2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Various technological procedures, such as solvent evaporation [ 22 ], electrospinning [ 37 , 38 ], sublimation [ 39 ], compression with a hydraulic press [ 40 ], and 3D printing technology [ 41 , 42 ], create different patch forms, including polymer films or non-woven materials, hydrogels, and cryogels. In addition, patches can be produced using layer-by-layer technology to create a structure by consecutive deposition of polymers with opposite charges [ 43 , 44 ]. The matrices obtained by various methods differ in the most important physicochemical characteristics (swelling and porosity), thereby affecting the mucoadhesion of these systems and the rate of drug release.…”

Section: Patches As Oromucosal Drug Delivery Systems For Topical Appl...mentioning

confidence: 99%

Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives

Dubashynskaya

Skorik

2022

IJMS

View full text Add to dashboard Cite

Mucoadhesive polymer patches are a promising alternative for prolonged and controlled delivery of topical corticosteroids (CS) to improve their biopharmaceutical properties (mainly increasing local bioavailability and reducing systemic toxicity). The main biopharmaceutical advantages of patches compared to traditional oral dosage forms are their excellent bioadhesive properties and their increased drug residence time, modified and unidirectional drug release, improved local bioavailability and safety profile, additional pain receptor protection, and patient friendliness. This review describes the main approaches that can be used for the pharmaceutical R&D of oromucosal patches with improved physicochemical, mechanical, and pharmacological properties. The review mainly focuses on ways to increase the bioadhesion of oromucosal patches and to modify drug release, as well as ways to improve local bioavailability and safety by developing unidirectional -release poly-layer patches. Various techniques for obtaining patches and their influence on the structure and properties of the resulting dosage forms are also presented.

show abstract

“…In a recent study, Paris et al [102] developed a mucoadhesive patch to deliver the protein using oppositely charged polyelectrolytes, chitosan, and hyaluronic acid. Au-thors visualized the distribution of ovalbumin from the conventional and mucoadhesive formulation using in vivo tomography analysis of protein residence time in the tongue.…”

Section: Chitosanmentioning

confidence: 99%

Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals

Subramanian

2021

Foods

View full text Add to dashboard Cite

The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the mucosal membrane through various interaction mechanisms and enhance the retention and permeability of bioactive compounds. Absorption of bioactive compounds from the mucosa can improve bioavailability, as this route bypasses the hepatic first-pass metabolism and transit through the gastrointestinal tract. The mucosal administration is convenient, simple to access, and reported for increasing the bioactive concentration in plasma. Many mucoadhesive polymers, emulsifiers, thickeners used for the pharmaceutical formulation are accepted in the food sector. Introducing mucoadhesive formulations specific to the nutraceutical sector will be a game-changer as we are still looking for different ways to improve the bioavailability of many bioactive compounds. This article describes the overview of buccal mucosa, the concept of mucoadhesion and related theories, and different techniques of mucoadhesive formulations. Finally, the classification of mucoadhesive polymers and the mucoadhesive systems designed for the effective delivery of bioactive compounds are presented.

show abstract

Sublingual protein delivery by a mucoadhesive patch made of natural polymers

Cited by 17 publications

References 40 publications

Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer

Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer

Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives

Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals

Contact Info

Product

Resources

About