Sublingual immunotherapy abrogates seasonal bronchial hyperresponsiveness in children with <i>Parietaria</i>‐induced respiratory allergy: a randomized controlled trial†

Pajno, Giovanni Battista; Passalacqua, Giovanni; Vita, Daniela De; Caminiti, Lucia; Parmiani, S.; Barberio, G

doi:10.1111/j.1398-9995.2004.00578.x

Cited by 68 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This might suggest that SLIT acts also on bronchial allergic inflammation, although it is well known that bronchial hyperreactivity is only in part attributable to inflammation itself. 22 The effect is consistent with that described in previous clinical trials with SLIT 23,24 and the injection route. 25 Concerning the effect on local allergic inflammation, this study offered the opportunity to follow up the effects on nasal eosinophils under the natural exposure to pollen and confirmed that the effect was consistent with the time.…”

Section: Discussionsupporting

confidence: 90%

Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study

Marogna¹,

Spadolini²,

Massolo³

et al. 2005

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study

Marogna¹,

Spadolini²,

Massolo³

et al. 2005

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…39,75,81 In studies that included 80% of all patients who underwent nonspecific bronchial challenge, there was a statistically significant increase in mean threshold that occurred in all studies with more than 12 months of SLIT administration. 31,35,39,41,57,92 In one study with serial measures of methacholine sensitivity, there was a progressive increase in threshold from 6 months to 18 to 24 months of SLIT. 35 In studies that included 71% of all patients who underwent specific nasal challenge, there was a statistically significant increase in mean threshold.…”

Section: Provocation Testsmentioning

confidence: 95%

Sublingual immunotherapy: A comprehensive review

Cox

Larenas‐Linnemann

Nolte

et al. 2006

Journal of Allergy and Clinical Immunology

361

289

View full text Add to dashboard Cite

“…A combined grass/olive extract vs. placebo administered to children 6 months before the pollen season did not result in different asthma outcomes between the groups, probably due to the low allergen season in which the study was conducted [161]. For Parietaria and tree polleninduced asthma, SLIT has shown to be effective in reduction of pulmonary symptoms [162,163], to the same extend as inhaled fluticasone propionate [164].…”

Section: Pediatric Populationsmentioning

confidence: 99%

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Domínguez‐Ortega

Delgado

Blanco

et al. 2017

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations. A systematic search of MEDLINE, Cochrane, and Clinical Trials databases from 2000 to April of 2016 was carried out by a panel of experts from the Spanish Allergy and Clinical Immunology Scientific Society. Relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. More than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on AIT, which was graded according to the Oxford classification. All the group members reviewed the resulting text until the final version reached the consensual agreement. A summary of recommendations on the more relevant topics are proposed. The role of AIT as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. Future research should include specific tools for asthma evaluation when assessing AIT effectiveness in asthmatic patients. ResumenEl asma se asocia frecuentemente con alergia, entendida ésta como la producción de IgE específica frente a alérgenos ambientales. Actualmente, existen dos tipos de inmunoterapia específica con alérgenos (ITE) para la práctica clínica habitual: subcutánea y sublingual, ambas indicadas en el tratamiento de la rinitis y la conjuntivitis alérgicas. Sin embargo, su papel en el asma resulta todavía controvertido. Dominguez-Ortega J, et al.

show abstract

Sublingual immunotherapy abrogates seasonal bronchial hyperresponsiveness in children with Parietaria‐induced respiratory allergy: a randomized controlled trial†

Abstract: Our data show that SLIT abrogates the seasonal bronchial hyperreactivity in children with asthma due to Parietaria. This may be regarded as an indirect evidence of the effect on bronchial inflammation.

Cited by 68 publications

References 36 publications

Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study

Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study

Sublingual immunotherapy: A comprehensive review

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Contact Info

Product

Resources

About