Sublingual hypoglossal neurilemmoma. Case report

Abstract

Neurilemmomas of the peripheral segment of the hypoglossal nerve are extremely uncommon neoplasms. A rare case of hypoglossal neurilemmoma located in the sublingual space is reported and the differential diagnosis of sublingual mass lesions is discussed.

Hypoglossal Schwannoma of Parapharyngeal Space: An Unusual Case Report

“…Classical features include necrosis, haemorrhage, and cystic degeneration. Nuclear palisading is also seen in some areas [3].…”

“…Clinical manifestations are variable depending on location and can be associated with neurofibromatosis [2]. Schwannomas of the hypoglossal nerve usually develop in the intracranial portion, but sometimes may develop in both the intra and the extra-cranial components forming a dumbbell shaped lesion [3]. Schwannomas usually arise from the sensory divisions of cranial nerves, most commonly the eighth and tenth cranial nerves.…”

Adult sublingual schwannoma with angioma-like features and foam cell vascular change

“…Although eight cases of sublingual schwannomas have been reported, only three have been studied for S100 protein [1,3,7], one of which has also been studied for neuron specific enolase, vimentin and Ki67 [1]. Tumour cells in our case expressed the S100 protein and neuron-specific enolase.…”

“…Schwannomas are benign tumours, extremely rare in a sublingual location, 9 cases being reported since 1960 to our knowledge [1,3,6,7,9,10,[12][13][14][15] (Table I). In the 8 reported cases with available data for review, there is a female gender prevalence of 5 : 3 (women : men).…”

“…In only one of the reported cases the schwannoma was intraglandular [10]. The diagnosis is made on the surgical specimen, after surgical resection, possibly due to their rarity in this setting and to nonspecific clinical complaints [1,3,6,7,9,10,[12][13][14][15]. Similarly to schwannomas in other locations, tumour cells express the S100 protein, neuron-specific enolase, and vimentin [13].…”