Sublingual Desensitization: A New Approach to Latex Allergy Problem

Patriarca, Giampiero; Nucera, Eleonora; Pollastrini, Emanuela; Roncallo, Chiara; Buonomo, Alessandro; Bartolozzi, Francesco; Pasquale, Tiziana De; Gasbarrini, Giovanni; Schiavino, Domenico

doi:10.1097/00000539-200210000-00031

Cited by 26 publications

(33 citation statements)

References 13 publications

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“…Using the above selection method, 25 studies with 1706 patients were included in this meta‐analysis (52–76). The studies included and their methods, participants, interventions, and outcomes are listed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Ten trials enrolled only children (54, 58, 61–63, 65, 66, 72, 73, 76). A wide range of allergens was administered: mites in eight studies (54, 55, 58, 61, 62, 64, 67, 72), pollen in 14 (52, 53, 56, 57, 60, 63, 65, 66, 68, 70, 71, 73, 75, 76), a mixture of allergens in two (59, 74), and latex in one (69).…”

Section: Resultsmentioning

confidence: 99%

“…Latex allergy was studied in one trial (69). Among the clinical manifestations included was a more serious condition of asthma together with rhinitis/conjunctivitis, urticaria/angioedema, and anaphylactic shock.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of sublingual immunotherapy in asthma: systematic review of randomized‐clinical trials using the Cochrane Collaboration method

Calamita

Saconato

Pelá

et al. 2006

Allergy

285

180

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Background: Sublingual immunotherapy (SLIT) is effective and safe in the treatment of allergic rhinitis. However, there is no meta‐analysis in asthma treatment. Methods: The clinical efficacy of SLIT for asthma was evaluated through a systematic review with meta‐analysis. MEDLINE (1966–2005), EMBASE (1974–2005), LILACS (1982–2005), and the Cochrane Library were searched for related literature in any language. Randomized‐controlled clinical trials (RCT) on SLIT in asthma treatment for adults and children were selected. From 119 citations, 25 studies with 1706 patients were included in this meta‐analysis. For each report, quality scores were assigned and data were extracted in relation to the outcomes analyzed: asthmatic symptoms, use of asthma medications, lung function, and bronchial provocation. Results: According to the Jadad quality method, 64% of the studies were assigned scores of 4 or 5. Immunotherapy was seen to significantly reduce asthma severity when parameter compositions were all analyzed by categorical outcomes. There was a nonsignificant reduction in asthma symptoms when analyzed using standardized mean differences. No severe reactions were observed. Conclusions: This meta‐analysis found that SLIT is beneficial for asthma treatment albeit the magnitude of the effect is not very large. Moreover, it is a safe alternative to the subcutaneous route. More RCT with standardization of symptom scores and medications are needed in order to contribute further to this subject.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of sublingual immunotherapy in asthma: systematic review of randomized‐clinical trials using the Cochrane Collaboration method

Calamita

Saconato

Pelá

et al. 2006

Allergy

285

180

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“…Surprisingly, a previous not controlled study [11] with the same extract and in a similar number of patients (26) shows an improvement in glove-use test and rubbing test after only 10 weeks of treatment (4-day build-up phase followed by 9 weeks of maintenance). However, likewise to our trial, no change was detected by the parallel line assay for prick test.…”

Section: Discussionmentioning

confidence: 80%

“…Patriarca et al [11] showed an improvement in skin and respiratory symptoms, and also in the conjunctival challenge test, but this was a non-controlled study. In another open-label and non-controlled study, Cistero [12] demonstrated a better tolerability of a rush sublingual immunotherapy than with the subcutaneous route, but only assessed the efficacy measuring a cutaneous response after 10 weeks.…”

Section: Introductionmentioning

confidence: 96%

Randomized, double-blind, placebo-controled clinical trial of sublingual immunotherapy in natural rubber latex allergic patients

Gastaminza

Algorta

Uriel

et al. 2011

Trials

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BackgroundNatural rubber latex allergy is a common and unsolved health problem. Since the avoidance of exposure is very difficult, immunotherapy is strongly recommended, but before its use in patients, it is essential to prove the efficacy and safety of extracts.The aim of the present randomised, double-blind, placebo-controlled clinical trial was to assess the efficacy and tolerability of latex sublingual immunotherapy in adult patients undergoing permanent latex avoidance.MethodsTwenty-eight adult latex-allergic patients (5 males and 23 females), with mean age of 39 years (range 24-57) were randomized to receive a commercial latex-sublingual immunotherapy or placebo during one year, followed by another year of open, active therapy. The following outcomes were measured at baseline and at the end of first and second year of follow-up: skin prick test, gloves-use score, conjunctival challenge test, total and specific IgE, basophil activation test, and adverse reactions monitoring.ResultsNo significant difference in any of the efficacy in vivo variables was observed between active and placebo groups at the end of the placebo-controlled phase, nor when each group was compared with their baseline values at the end of the two year-study. An improvement in the average percentage of basophils activated was observed. During the induction phase, 4 reactions in the active group and 5 in the placebo group were recorded. During the maintenance phase, two patients dropped out due to pruritus and to acute dermatitis respectively.ConclusionFurther studies are needed to evaluate latex-sublingual immunotherapy, since efficacy could not be demonstrated in adult patients with avoidance of the allergen.Trial registration numberACTRN12611000543987

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Latex Allergy in Children with Spina Bifida

Esposito

Savanelli

Leggio

et al.

Pediatric Neurogenic Bladder Dysfunction

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Sublingual Desensitization: A New Approach to Latex Allergy Problem

Abstract: We present 12 cases of latex allergy in patients who underwent desensitization by a sublingual exposure protocol. This study provides evidence that a safe therapeutic approach to latex allergy is possible.

Cited by 26 publications

References 13 publications

Efficacy of sublingual immunotherapy in asthma: systematic review of randomized‐clinical trials using the Cochrane Collaboration method

Efficacy of sublingual immunotherapy in asthma: systematic review of randomized‐clinical trials using the Cochrane Collaboration method

Randomized, double-blind, placebo-controled clinical trial of sublingual immunotherapy in natural rubber latex allergic patients

Latex Allergy in Children with Spina Bifida

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