Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data

Fratter, Andrea; Biagi, Damiano; Cicero, Arrigo F G

doi:10.3390/md17090508

Cited by 16 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Astaxanthin is a xanthophyll carotenoid that can be transported into the brain through the blood‐brain barrier 8 . In addition to its antioxidant activity, astaxanthin exhibits anti‐inflammatory and antitumour properties 9‐11 .…”

Section: Resultsmentioning

confidence: 99%

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways

Chen

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Pulmonary fibrosis is a chronic interstitial lung disease characterized by pulmonary epithelial injury, fibroblast activation, extracellular matrix deposition, and tissue structure destruction. However, an effective drug treatment remains unavailable. Therefore, studying the mechanism of pulmonary fibrogenesis and finding effective drugs have become important problems in the field of respiratory diseases. Pulmonary fibrosis is typically characterized by activated fibroblast proliferation and migration. Hence, abnormality in activated fibroblast proliferation and migration is a major concern for treating pulmonary fibrosis. Long noncoding RNA (lncRNA) is an enigmatic subclass of ncRNA that regulates various fundamental biological processes and participates in disease occurrence and development. However, studies on lncRNA as the therapeutic target of drug action are rarely reported. Our group first identified differentially expressed lncRNAs and revealed that lncITPF is a highly upregulated lncRNA in lung fibrosis. In particular, lncITPF is detected in the blood of patients with idiopathic pulmonary fibrosis. Clinical analysis shows that lncITPF is positively correlated with the degree of fibrosis. The receiver operating characteristic (ROC) curve indicates that the specificity and sensitivity values are 95.0 and 64.3, respectively. The area under the ROC curve is 0.804, indicating that lncITPF can be a diagnostic biomarker for IPF. However, whether lncITPF is effective as a therapeutic target of drug action against pulmonary fibrosis remains unclear. In this study, lncITPF acting as the therapeutic target of astaxanthin was explored in depth. The findings elucidated that astaxanthin blocks the activated fibroblast proliferation and migration through lncITPF and mitochondria‐mediated signal pathways to alleviate pulmonary fibrogenesis.

show abstract

Section: Resultsmentioning

confidence: 99%

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways

Chen

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Considered together, the large safety profile of this carotenoid [70] and its potential usefulness in a number of largely prevalent systemic diseases [71,72] opens up new perspectives of treatment aiming at supporting, preserving and improving eye health, as well as contrasting the natural course of ocular diseases. In order to improve its beneficial effects, studies are needed to improve its bioavailability [73], while more data from randomized controlled studies conducted on clearly defined population groups are desirable to define appropriate dosage and exact composition to be used according to the different clinical indication. Funding: This research received no external funding.…”

Section: Discussionmentioning

confidence: 99%

Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights

et al. 2020

Self Cite

View full text Add to dashboard Cite

Astaxanthin is a naturally occurring red carotenoid pigment belonging to the family of xanthophylls, and is typically found in marine environments, especially in microalgae and seafood such as salmonids, shrimps and lobsters. Due to its unique molecular structure, astaxanthin features some important biologic properties, mostly represented by strong antioxidant, anti-inflammatory and antiapoptotic activities. A growing body of evidence suggests that astaxanthin is efficacious in the prevention and treatment of several ocular diseases, ranging from the anterior to the posterior pole of the eye. Therefore, the present review aimed at providing a comprehensive evaluation of current clinical applications of astaxanthin in the management of ocular diseases. The efficacy of this carotenoid in the setting of retinal diseases, ocular surface disorders, uveitis, cataract and asthenopia is reported in numerous animal and human studies, which highlight its ability of modulating several metabolic pathways, subsequently restoring the cellular homeostatic balance. To maximize its multitarget therapeutic effects, further long-term clinical trials are warranted in order to define appropriate dosage, route of administration and exact composition of the final product.

show abstract

“…Other options include encapsulation with lipoprotein aggregates, maltodextrin, pectin, or chitosan [ 155 ]. Newer encapsulation methods have also been developed such as oleic acid–bovine serum albumin complexes nanoparticles [ 196 ], which are able to find products that, for example, use nanoemulsions with ascorbyl palmitate in sublingual application to favor the absorption and bioavailability of AS [ 158 ]. Nevertheless, as AS may be easily degraded by digestive acids, intake after digestion has shown increased levels of absorption [ 197 ].…”

Section: Mechanism Of Action Of Xanthophyllsmentioning

confidence: 99%

Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids

et al. 2021

View full text Add to dashboard Cite

Algae are considered pigment-producing organisms. The function of these compounds in algae is to carry out photosynthesis. They have a great variety of pigments, which can be classified into three large groups: chlorophylls, carotenoids, and phycobilins. Within the carotenoids are xanthophylls. Xanthophylls (fucoxanthin, astaxanthin, lutein, zeaxanthin, and β-cryptoxanthin) are a type of carotenoids with anti-tumor and anti-inflammatory activities, due to their chemical structure rich in double bonds that provides them with antioxidant properties. In this context, xanthophylls can protect other molecules from oxidative stress by turning off singlet oxygen damage through various mechanisms. Based on clinical studies, this review shows the available information concerning the bioactivity and biological effects of the main xanthophylls present in algae. In addition, the algae with the highest production rate of the different compounds of interest were studied. It was observed that fucoxanthin is obtained mainly from the brown seaweeds Laminaria japonica, Undaria pinnatifida, Hizikia fusiformis, Sargassum spp., and Fucus spp. The main sources of astaxanthin are the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp. Lutein and zeaxanthin are mainly found in algal species such as Scenedesmus spp., Chlorella spp., Rhodophyta spp., or Spirulina spp. However, the extraction and purification processes of xanthophylls from algae need to be standardized to facilitate their commercialization. Finally, we assessed factors that determine the bioavailability and bioaccesibility of these molecules. We also suggested techniques that increase xanthophyll’s bioavailability.

show abstract

Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data

Cited by 16 publications

References 33 publications

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways

Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights

Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids

Contact Info

Product

Resources

About