Sublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers

Alekseeva, Polina; Efendiev, Kanamat; Shiryaev, Artem; Rusakov, M A; Simonova, M S; Samoylova, Svetlana I.; Fatyanova, Anastasia S.; Reshetov, Igor V.; Loschenov, Victor B.

doi:10.1016/j.pdpdt.2021.102289

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…The disease course is often asymptomatic, complicating diagnosis further. Oral potentially malignant diseases, which are significantly more likely to transform into cancers, are seldom diagnosed in a timely manner [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…The glucose in the dose supports active transport of 5-ALA into cells, and avoids the risk of aspiration associated with anaesthesia when administered orally. The development of a sublingual administration route may improve the efficacy of PDT and PD whilst negating side effects associated with other routes, thus improving tolerability [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Laryngeal Carcinomamentioning

confidence: 99%

“…Therefore, surgical and radiotherapy techniques have evolved to spare organs and restore/preserve function as much as possible. PDT is therefore a useful technique in the management of cancers of this region, because it has little effect on underlying structures [71][72][73][74][75][76][77][78][79]82] (Table 4) (Figures 14 and 15). Biel treated 115 patients with early laryngeal carcinomas (carcinoma in situ/T1/T2) with photofrin at a dose of 2 mg/kg and DLI of 48 h. A total of 105 patients showed a Biel treated 115 patients with early laryngeal carcinomas (carcinoma in situ/T1/T2) with photofrin at a dose of 2 mg/kg and DLI of 48 h. A total of 105 patients showed a Biel treated 115 patients with early laryngeal carcinomas (carcinoma in situ/T1/T2) with photofrin at a dose of 2 mg/kg and DLI of 48 h. A total of 105 patients showed a complete response, at a mean of 91 months follow-up.…”

Section: Laryngeal Carcinomamentioning

confidence: 99%

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From Basic Mechanisms to Clinical Research: Photodynamic Therapy Applications in Head and Neck Malignancies and Vascular Anomalies

Ramsay

Stevenson

Jerjes

2021

JCM

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Head and neck cancers are largely squamous cell carcinomas derived from the epithelial lining of the structures in the region, and are often classified anatomically into oral, oropharyngeal, nasopharyngeal and laryngeal carcinomas. The region’s component structures serve complex and intricate functions, such as speaking, swallowing and breathing, which are often compromised by these neoplasms. Such lesions may also cause disfigurement, leading to distressing social and psychological issues. Conventional treatments of these neoplasms usually involve surgical intervention with or without chemoradiotherapy. These have shown to be efficacious; however, they can also cause damage to healthy as well as diseased tissue, exacerbating the aforementioned problems. Access to a given region to deliver the treatments is also often a problem, due to the complex anatomical structures involved. The use of photodynamic therapy in the head and neck region has been established for about two decades. In this review, we looked at the basic mechanisms of this intervention, examined its use in common head and neck malignancies and vascular anomalies, and reported on the most recent clinical studies. We further included a clinical guide which can help replicate the use of this technology by any unit. Based on this review, photodynamic therapy has been shown to be efficacious in the treatment of head and neck malignancies and vascular tumours. This therapy can be targeted to the diseased tissue and causes no damage to underlying structures. Recent studies have shown this therapy to be as effective as conventional therapies, without causing major adverse effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%