Sublineages of lineage 4 (Euro-American) <i>Mycobacterium tuberculosis</i> differ in genotypic clustering

Anderson, J.P.; Jarlsberg, Leah G.; Grindsdale, J; Osmond, Dennis; Kawamura, Makiko; Hopewell, Philip C.; Kato‐Maeda, Midori

doi:10.5588/ijtld.12.0960

Cited by 9 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Delhi/CAS genotype had the highest prevalence with 59 (28.9%) isolates. A study by [29] In our study sensitivity testing showed Delhi/ CAS as having the highest resistance followed by Beijing. Beijing has been associated with resistance in different parts of the world.…”

Section: Discussionsupporting

confidence: 50%

Mycobacteria Interspersed Repetitive Units-Variable Number of Tandem Repeat, Spoligotyping and Drug Resistance of Isolates from Pulmonary Tuberculosois Patients in Kenya

Ndung’u¹,

Kariuki²,

Revathi³

et al. 2017

AiM

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 50%

Mycobacteria Interspersed Repetitive Units-Variable Number of Tandem Repeat, Spoligotyping and Drug Resistance of Isolates from Pulmonary Tuberculosois Patients in Kenya

Ndung’u¹,

Kariuki²,

Revathi³

et al. 2017

AiM

View full text Add to dashboard Cite

show abstract

“…This sub-lineage was also more virulent in guinea pigs, supporting again an intrinsic bacterial role in increased pathogenicity linked to enhanced transmission [176]. Sub-lineages of other lineages also tend to differ in their transmissibility as observed in San Francisco, USA for Lineage 4 [203] and Cotonu, Benin for Lineage 5 [72]. However, three studies have reported decreasing prevalence of M. africanum (i.e.…”

Section: The Consequences Of Genomic Diversity In Mtbcmentioning

confidence: 98%

Consequences of genomic diversity in Mycobacterium tuberculosis

Coscollá

Gagneux

2014

Seminars in Immunology

365

348

View full text Add to dashboard Cite

The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC), comprises seven phylogenetically distinct lineages associated with different geographical regions. Here we review the latest findings on the nature and amount of genomic diversity within and between MTBC lineages. We then review recent evidence for the effect of this genomic diversity on mycobacterial phenotypes measured experimentally and in clinical settings. We conclude that overall, the most geographically widespread Lineage 2 (includes Beijing) and Lineage 4 (also known as Euro-American) are more virulent than other lineages that are more geographically restricted. This increased virulence is associated with delayed or reduced pro-inflammatory host immune responses, greater severity of disease, and enhanced transmission. Future work should focus on the interaction between MTBC and human genetic diversity, as well as on the environmental factors that modulate these interactions.

show abstract

“…Studies examining biological consequences of genotypic variations within sublineages is limited. In a study conducted in San Francisco, USA, a sub-lineage of Lineage 4 significantly differed in its transmissibility in comparison to other strains in the lineage 61 . A systematic review of MTBC in Africa revealed no link between Mtb lineage and clinical presentation of disease, but within Lineage 4 some sublineages were found to be associated more frequently with lymphnode TB than PTB 62 .…”

Section: Discussionmentioning

confidence: 99%

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

et al. 2022

View full text Add to dashboard Cite

Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent temporal events of early dissemination of bacteria to the lymph nodes, Th1 priming, granulomatous response and bacterial control. In contrast, IL-1R-dependent alveolar macrophage migration and early dissemination of bacteria to lymph nodes is significantly impeded in infection with low transmission M.tuberculosis strain; these events promote the development of Th17 immunity, fostering neutrophilic inflammation and increased bacterial replication. Our results suggest that by inducing granulomas with the potential to develop into cavitary lesions that aids bacterial escape into the airways, high transmission M.tuberculosis strain is poised for greater transmissibility. These findings implicate bacterial heterogeneity as an important modifier of TB disease manifestations and transmission.

show abstract

Sublineages of lineage 4 (Euro-American) Mycobacterium tuberculosis differ in genotypic clustering

Cited by 9 publications

References 0 publications

Mycobacteria Interspersed Repetitive Units-Variable Number of Tandem Repeat, Spoligotyping and Drug Resistance of Isolates from Pulmonary Tuberculosois Patients in Kenya

Mycobacteria Interspersed Repetitive Units-Variable Number of Tandem Repeat, Spoligotyping and Drug Resistance of Isolates from Pulmonary Tuberculosois Patients in Kenya

Consequences of genomic diversity in Mycobacterium tuberculosis

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

Contact Info

Product

Resources

About