Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species

Fitzgerald, Jennifer A.; Urbina, Mauricio G.; Rogers, Nicholas J.; Bury, Nic; Katsiadaki, Ioanna; Wilson, Rod W.; Santos, Eduarda M.

doi:10.1016/j.aquatox.2019.105325

Cited by 15 publications

(7 citation statements)

References 56 publications

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“…2A). This contrasts recent findings in three-spined stickleback (Gasterosteus aculeatus), in which waterborne copper exposure (20 μg/l) impaired improvements in Pcrit that result from hypoxia acclimation (Fitzgerald et al, 2019). Pcrit is often considered to reflect the ability to extract oxygen from the environment during hypoxia, and is considered to be a useful indicator of hypoxia tolerance in many species (Regan et al, 2019;Rogers et al, 2016;Speers-Roesch et al, 2013).…”

Section: Wastewater Exposure Disrupts Responses To Chronic Hypoxiacontrasting

confidence: 73%

Exposure to wastewater effluent disrupts hypoxia responses in killifish (Fundulus heteroclitus)

Lau

Mehdi

Bragg

et al. 2021

Environmental Pollution

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Section: Wastewater Exposure Disrupts Responses To Chronic Hypoxiacontrasting

confidence: 73%

Exposure to wastewater effluent disrupts hypoxia responses in killifish (Fundulus heteroclitus)

Lau

Mehdi

Bragg

et al. 2021

Environmental Pollution

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“…Copper exposure has been shown to interfere with aquatic organisms' ability to deal with other stressors. Fitzgerald et al (2019) found that Cu exposure prevented sticklebacks ( Gasterosteus aculeatus ) from acclimating to hypoxia, which may be due to Cu's ability to suppress the cortisol stress response in fish. This makes it more difficult for the fish to respond to concurrent stressors (Nascimento et al, 2012; Tellis et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Transient Copper Exposure During Embryogenesis and Temperature Affect Developmental Rate, Survival, and Fin Regeneration in Japanese Medaka (Oryzias latipes)

Mason

Bertucci

Leri

et al. 2022

Enviro Toxic and Chemistry

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Combined environmental stressors that an organism experiences can have both immediate and lasting consequences. In the present study, we exposed Japanese medaka (Oryzias latipes) embryos to sublethal copper sulfate (CuSO4; 0, 10, and 100 ppb) in combination with different rearing temperatures (27, 30, and 33 °C) to assess acute and latent effects on development, growth, and regenerative capacity. Embryos exposed to CuSO4 and/or higher temperatures hatched significantly earlier. At 4 months post‐exposure, fish exposed to low levels of CuSO4 during development had higher survival, whereas fish exposed to both 100 ppb CuSO4 and 33 °C temperatures had significantly lower survival. In addition, a sex‐specific effect of embryonic CuSO4 exposure was observed as female mass decreased with increasing Cu dose. We also assessed caudal fin regenerative capabilities in both embryo‐exposed fish at 4 months of age and adult medaka that were exposed to 0, 10, and 100 ppb CuSO4 at room temperature during a 14‐day trial. Whereas fin regeneration was unaffected by adult exposure to Cu, fish transiently exposed during embryogenesis displayed an initial increase in fin growth rate and an increased incidence of abnormal fin morphology following regrowth. Collectively, these data suggest that developmental Cu exposure has the potential to exert long‐lasting impacts to organismal growth, survival, and function. Environ Toxicol Chem 2022;41:748–757. © 2021 SETAC

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“…Research into how hypoxic conditions affect the physiology of aquatic organisms and their ability to cope with chemical toxicity is much needed given the large (and increasing) expanse of surface waters experiencing such conditions. Recent studies on interactions between hypoxia and metal toxicity in zebrafish and threespined stickleback highlight the potential for major impacts of environmental oxygen (Fitzgerald et al, 2016(Fitzgerald et al, , 2019Fitzgerald, Katsiadaki & Santos, 2017). For example, hypoxia halved the toxicity of copper during a continuous 4-day exposure in zebrafish embryos.…”

Section: ) Oxygenmentioning

confidence: 99%

Global variation in freshwater physico‐chemistry and its influence on chemical toxicity in aquatic wildlife

et al. 2021

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Chemical pollution is one of the major threats to global freshwater biodiversity and will be exacerbated through changes in temperature and rainfall patterns, acid–base chemistry, and reduced freshwater availability due to climate change. In this review we show how physico‐chemical features of natural fresh waters, including pH, temperature, oxygen, carbon dioxide, divalent cations, anions, carbonate alkalinity, salinity and dissolved organic matter, can affect the environmental risk to aquatic wildlife of pollutant chemicals. We evidence how these features of freshwater physico‐chemistry directly and/or indirectly affect the solubility, speciation, bioavailability and uptake of chemicals [including via alterations in the trans‐epithelial electric potential (TEP) across the gills or skin] as well as the internal physiology/biochemistry of the organisms, and hence ultimately toxicity. We also show how toxicity can vary with species and ontogeny. We use a new database of global freshwater chemistry (GLORICH) to demonstrate the huge variability (often >1000‐fold) for these physico‐chemical variables in natural fresh waters, and hence their importance to ecotoxicology. We emphasise that a better understanding of chemical toxicity and more accurate environmental risk assessment requires greater consideration of the natural water physico‐chemistry in which the organisms we seek to protect live.

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Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species

Cited by 15 publications

References 56 publications

Exposure to wastewater effluent disrupts hypoxia responses in killifish (Fundulus heteroclitus)

Exposure to wastewater effluent disrupts hypoxia responses in killifish (Fundulus heteroclitus)

Transient Copper Exposure During Embryogenesis and Temperature Affect Developmental Rate, Survival, and Fin Regeneration in Japanese Medaka (Oryzias latipes)

Global variation in freshwater physico‐chemistry and its influence on chemical toxicity in aquatic wildlife

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