Subjective Responses to Various Filling Solutions in the Posterior Fluid Reservoir of Miniscleral Lenses at Application

Abstract

To compare the effect of the use of different lubrication eye drops and nonpreserved saline for the application of miniscleral contact lenses (CLs) on subjective experience during 6 hr of lens wear. Methods: Experienced soft CL wearers aged 18 to 45 years (inclusive) were enrolled in this prospective, randomized, double-masked, three arm comparison cross-over study. Subjects were custom fitted with KATT 16.5 mm diameter miniscleral lenses, ordered to their prescription. Subjects attended visits on three separate days and were randomized to receive instillation of an HP-guar/nanoemulsion drop or an HP-guar/sodium hyaluronate (HA) eye drop into the miniscleral lens before filling with saline or filling with saline alone (control). Subjective responses were collected up to 6 hr postapplication. Generalized linear mixed models with multinomial distribution and cumulative logit link were used to compare the rate at which responses improved post-CL application for the different treatments.Results: Twenty-four participants completed the study. Dryness symptoms were more likely to improve at a slower rate postlens application with saline alone compared with the addition of HP-guar/nanoemulsion (P¼0.005) or HP-guar/HA (P¼0.049) before lens application. Furthermore, the addition of HP-guar/nanoemulsion was more effective than saline alone in improving symptoms of fluctuating vision (P¼0.011), grittiness/burning/stinging (P¼0.001), and foreign body sensation (P¼0.006) more quickly. Conclusions: The use of postlens lubrication may be useful in enhancing adaptation to miniscleral lenses.

Propylene Glycol and Hydroxypropyl Guar Nanoemulsion - Safe and Effective Lubricant Eye Drops in the Management of Dry Eye Disease

“… 55 In this study, PG-HPG nanoemulsion eye drops (along with saline) were effective in improving various symptoms faster than saline, whereas HPG/HA eye drops only improved symptoms of dryness. 55 Overall, PG-HPG nanoemulsion lubricant eye drops improved subjective outcomes of symptoms and comfort, and was well tolerated in patients with daily contact lens wear. 53–55 …”

“…55 In this study, PG-HPG nanoemulsion eye drops (along with saline) were effective in improving various symptoms faster than saline, whereas HPG/HA eye drops only improved symptoms of dryness. 55…”

“…Results demonstrated that PG-HPG nanoemulsion eye drop instillation in combination with non-preserved saline for application of miniscleral contact lenses during 6 hours of wear effectively improved subjective dryness (estimates±standard error [SE], −1.69±0.58, p=0.005); grittiness/burning/stinging (−1.99±0.58, p=0.001), and foreign body sensation (−1.61±0.57, p=0.006); and fluctuating vision (−1.50±0.57, p=0.011) compared to saline. 55 Dryness symptoms improved faster with PG-HPG nanoemulsion and HPG/HA eye drops than saline, as indicated by higher percentage of patients reporting improvement in dryness at 5 min after lens application (50% vs 42% vs 0%). 55 In this study, PG-HPG nanoemulsion eye drops (along with saline) were effective in improving various symptoms faster than saline, whereas HPG/HA eye drops only improved symptoms of dryness.…”

“… 55 Dryness symptoms improved faster with PG-HPG nanoemulsion and HPG/HA eye drops than saline, as indicated by higher percentage of patients reporting improvement in dryness at 5 min after lens application (50% vs 42% vs 0%). 55 In this study, PG-HPG nanoemulsion eye drops (along with saline) were effective in improving various symptoms faster than saline, whereas HPG/HA eye drops only improved symptoms of dryness. 55 Overall, PG-HPG nanoemulsion lubricant eye drops improved subjective outcomes of symptoms and comfort, and was well tolerated in patients with daily contact lens wear.…”

“…54 A very recent prospective, single-center, nondispensing, randomized, double-masked, three arm study evaluated filling solutions for the application of miniscleral contact lenses in participants (N=24; average age, 29.3±5.4 years; 13 female; 11 male). 55 The study compared PG-HPG nanoemulsion (Systane TM Complete), HPG/HA eye drops (Systane TM Hydration), and no treatment (saline). Results demonstrated that PG-HPG nanoemulsion eye drop instillation in combination with non-preserved saline for application of miniscleral contact lenses during 6 hours of wear effectively improved subjective dryness (estimates±standard error [SE], −1.69±0.58, p=0.005); grittiness/burning/stinging (−1.99 ±0.58, p=0.001), and foreign body sensation (−1.61±0.57, p=0.006); and fluctuating vision (−1.50±0.57, p=0.011) compared to saline.…”