Subjective response to antipsychotics in schizophrenic patients: clinical implications and related factors

Attitudes Towards Antipsychotics Among Patients with Schizophrenia on First- or Second-Generation Medications

“…This was consistent with the results of several previous studies on this aspect. [21213142333] However, unlike other studies,[231112131422232933] severity of symptoms explained only a negligible proportion of the variance in attitudes in the present study. This could be attributed to the nature of the sample, which largely consisted of chronically ill, but stable patients with moderate levels of psychopathology.…”

“…[31112222728] However, others have failed to demonstrate an association between side-effects and attitudes. [2329303132] In studies reporting an association between side-effects and attitudes, extrapyramidal side-effects, sedation and sexual dysfunctions have emerged as major correlates of negative attitudes. This is partly due to the fact that that either all,[1112] or a large proportion of patients in these studies were being treated with FGAs.…”

Subjective response to antipsychotic treatment and compliance in schizophrenia. A naturalistic study comparing olanzapine, risperidone and haloperidol (EFESO Study)

“…Using different measurement scales, other studies [1,35,2,25,26,19] have highlighted the importance of subjective response in a subject's decision to take antipsychotic medication. It seems logical that how a patient feels and operates is going to influence future compliance [20]. Nevertheless, it is important to take into account that compliance was measured in an exploratory fashion, using a scale that could benefit from additional development and validation.…”

“…Some authors feel that patient complaints may reflect extrapyramidal or autonomic symptoms, particularly syndromes of akinesia [14] or akathisia [15,7,17]. Further, a relationship has been inferred between subjective response and patient attitudes towards health [18] or illness [19,20] or with the presence of mood changes, mainly depression and organic depression [21,22]. There have also been attempts to relate the mesolimbic antidopaminergic action of neuroleptic drugs to subjective response.…”

Drug-induced sexual dysfunction and mental health patients' attitude to psychotropic medications

“…This suggests that healthcare practitioners' concern around patients' reluctance to discuss sexual issues is not grounded in evidence. Several factors influence adherence to medication: a positive attitude towards treatment is predictive of adherence (Garcia Cabeza, Sanz Amador, Arango Lopez, & Gonzalez de Chavez, 2000;Hofer et al, 2007) and, likewise, a negative attitude to medication has negative impacts on adherence to treatments (Lambert et al, 2004;O'Donnell et al, 2003). More importantly, a person's experience of side-effects and subjective interpretation of altered physiologic functions determines the extent of adherence to medications (Awad, 1993).…”