Subjective Response to Alcohol as a Research Domain Criterion

Ray, Lara A.; Bujarski, Spencer; Roche, Daniel

doi:10.1111/acer.12927

Cited by 58 publications

(64 citation statements)

References 110 publications

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“…A final goal of this study was to examine whether P3 reactivity to smoking cues was related to low alcohol sensitivity, a trait associated with risk for alcohol use disorder (see Ray et al, 2016; Trim et al, 2009) and with exaggerated P3 to alcohol cues (Bartholow, et al, 2007, 2010). We found that lower alcohol sensitivity was associated with differentially larger P3 to smoking cues.…”

Section: Discussionmentioning

confidence: 99%

P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.

Piasecki¹,

Fleming²,

Trela³

et al. 2017

Psychology of Addictive Behaviors

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The current study tested whether the amplitude of the P3 event-related potential (ERP) elicited by smoking cues is (a) associated with the degree of self-reported craving reactivity, and (b) moderated by degree of tobacco dependence. Because alcohol and cigarettes are frequently used together, and given recent evidence indicating that individual differences in alcohol sensitivity influence reactivity to alcohol cues, we also investigated whether alcohol sensitivity moderated neural responses to smoking cues. ERPs were recorded from young adult smokers (N = 90) while they participated in an evaluative categorization oddball task involving three types of targets: neutral images, smoking-related images, and images of drinking straws. Participants showing larger P3 amplitudes to smoking cues and to straw cues (relative to neutral targets) reported greater increases in craving after cue exposure. Neither smoking status (daily vs. occasional use) nor psychometric measures of tobacco dependence consistently or specifically moderated P3 reactivity to smoking cues. Lower alcohol sensitivity was associated with larger P3 to smoking cues but not comparison straw cues (relative to neutral targets). This effect was further moderated by tobacco dependence, with the combination of lower sensitivity and higher dependence associated with especially pronounced P3 reactivity to smoking cues. The findings suggest the smoking-cue elicited P3 ERP component indexes an approach-oriented incentive motivational state accompanied by a subjective sense of cigarette craving. Self-reported low sensitivity to the pharmacologic effects of alcohol may represent a marker of drug cue reactivity and therefore deserves attention as a potential moderator in smoking cue exposure studies.

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Section: Discussionmentioning

confidence: 99%

P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.

Piasecki¹,

Fleming²,

Trela³

et al. 2017

Psychology of Addictive Behaviors

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“…Subjective response (SR) to alcohol, which refers to one's subjective experiences of the pharmacological effects of alcohol, and impulsivity, a personality trait defined by a failure to delay rewards and to control thoughts and behaviors, are two well-established predictors of problematic drinking (Dick et al, 2010;Ray et al, 2016). There are two predominant views of SR as a risk factor for alcohol use disorder (AUD).…”

Section: Introductionmentioning

confidence: 99%

Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals

Westman

Bujarski

Ray

2016

Alcohol and Alcoholism

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Aims: Studies of social drinkers indicate that subjective response (SR) to alcohol and impulsivity are risk factors for the development of alcohol use disorder which may be related. It is unclear, however, whether there are significant relationships between SR and impulsivity among individuals with alcohol dependence. Using data from an intravenous (IV) alcohol challenge study, the present study is the first to explore the relationship between impulsivity and SR during alcohol administration among alcohol-dependent individuals. Methods: Non-treatment-seeking, alcohol-dependent individuals (N = 42) completed the Delay Discounting Task to measure impulsivity and then completed two counterbalanced, placebocontrolled IV alcohol administration sessions, which included assessments of SR at breath alcohol concentration (BrAC) levels of 0.00, 0.02, 0.04 and 0.06 g/dl. Results: Analyses revealed that more impulsive participants experienced higher subjective stimulation and positive mood in response to rising BrACs as compared to less impulsive individuals. More impulsive participants also experienced increased sedation over time regardless of condition (i.e. alcohol vs. saline). Conclusion: These findings suggest that among alcohol-dependent individuals, impulsivity is positively associated with the hedonic effects of alcohol as compared to placebo. High impulsivity may characterize a subset of alcohol-dependent individuals who drink to experience the rewarding effects of alcohol.

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“…Forced alcohol administration and alcohol cue-reactivity are reliable methods used to measure subjective response to alcohol and alcohol craving, respectively (Ray et al, 2016). However, several promising pharmacotherapies for AUD have not reduced the positive subjective effects of alcohol in the laboratory (reviewed elsewhere, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…However, several promising pharmacotherapies for AUD have not reduced the positive subjective effects of alcohol in the laboratory (reviewed elsewhere, e.g. Ray et al, 2016). Thus, IVM could feasibly have utility in treating AUD without affecting subjective response to alcohol.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder

Roche

Yardley

Lunny

et al. 2016

Alcoholism Clin & Exp Res

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Background Ivermectin (IVM) is an antiparasitic agent that has been shown to reduce alcohol intake in mice, suggesting IVM as a potential treatment for alcohol use disorder (AUD). However, the safety profile of IVM administered in combination with an intoxicating dose of alcohol has not been characterized in humans. Methods This pilot project sought to provide the first clinical evidence that IVM could be repositioned as an AUD pharmacotherapy by examining 1) the safety of combining IVM (30 mg oral QD) with an intoxicating dose of intravenous alcohol (0.08 g/dl) and 2) the effects of IVM on alcohol cue-induced craving and subjective response to alcohol. Eleven individuals with AUD participated in a randomized, placebo-controlled, crossover study in which they received the study medication, participated in a cue exposure paradigm followed by intravenous alcohol administration, and remained in an inpatient unit overnight for observation. Results Ivermectin treatment, vs. placebo, did not increase the number or severity of adverse effects during alcohol administration or throughout the visit. However, IVM did not reduce cue-induced craving nor did it significantly affect subjective response to alcohol. Conclusions These results suggest that IVM (30 mg oral, QD) is safe in combination with an intoxicating dose of alcohol, but do not provide evidence that this dose of IVM is effective in reducing alcohol craving or its reinforcing effects. Given the preclinical data suggesting IVM is effective in reducing alcohol consumption in mice, additional studies testing larger samples and alternate dosing regimens are warranted to further characterize the potential efficacy of IVM as an AUD treatment.

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Subjective Response to Alcohol as a Research Domain Criterion

Cited by 58 publications

References 110 publications

P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.

P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.

Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals

A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder

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