Subjective memory complaints in community dwelling healthy older people: the influence of brain and psychopathology

Bartley, Mairead M.; Bokde, Arun L.W.; Ewers, Michael; Faluyi, Yetunde; Tobin, W. Oliver; Snow, Aisling; Connolly, Joanna; Delaney, Conor P.; Coughlan, Tara; Collins, Rónán; Hampel, Harald; O’Neill, Desmond

doi:10.1002/gps.2794

Cited by 39 publications

(44 citation statements)

References 36 publications

(38 reference statements)

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“…The association between SMC and incidence of dementia has been suggested to be stronger in people with less severe cognitive impairment [1, 16] but weaker in those with depression [11]. SMC is associated with a number of other states including depression [6, 8, 17–19], anxiety [17, 18], worse physical health [6, 20] and personality traits, such as neuroticism [6, 21]. Inconsistencies may arise in part because of different SMC measures [1, 22], different sample populations, limited cognitive tests, and failure to take depression into consideration [1, 21].…”

Section: Introductionmentioning

confidence: 99%

The association between subjective memory complaint and objective cognitive function in older people with previous major depression

et al. 2017

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The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression–a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was defined on the basis of a score ≧4 on the subscale of Geriatric Mental State schedule, a maximum score of 8. Older people aged equal or over 60 without any psychiatric diagnosis were enrolled as healthy controls. Cognitive function was evaluated using a series of cognitive tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility in all participants. One hundred and thirteen older people with previous major depression and forty-six healthy controls were enrolled. Subjective memory complaint was present in more than half of the participants with depression history (55.8%). Among those with major depression history, subjective memory complaint was associated with lower total immediate recall and delayed verbal recall scores after adjustment. The associations between subjective memory complaint and worse memory performance were stronger in participants with lower depressive symptoms (Hamilton Depression Rating Scale score<7). The results suggest subjective memory complaint may be a valid appraisal of memory performance in older people with previous major depression and consideration should be given to more proactive assessment and follow-up in these clinical samples.

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Section: Introductionmentioning

confidence: 99%

The association between subjective memory complaint and objective cognitive function in older people with previous major depression

et al. 2017

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“…Subjective memory complaints (SMC) may represent an early phase of cognitive decline, and may be an earlier harbinger of AD than MCI [2]. Persons with SMC score normally on standardized cognitive tests, and those with AD are interspersed among others with SMC due to various reasons [3, 4]. SMC can nevertheless predict dementia earlier than MCI [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors

Rogne

Vangberg

Eldevik

et al. 2016

Dement Geriatr Cogn Disord Extra

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Background/Aims: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer’s disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer’s disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, and cardiovascular risk factors were associated with MR volumetric findings. Methods: 198 stroke-free subjects comprised the control (n = 58), the SMC (n = 25) and the MCI (n = 115) groups. Analysis of covariance and receiver operating characteristic curve was used to see if MR volumetry distinguished subjects with SMC and MCI from controls. Results: Subjects with SMC and MCI had significantly larger lateral ventricles and smaller hippocampal volumes than controls. The area under the curve in subjects with SMC and MCI compared to that of controls was less than 0.68 for all volumes of intracranial structures. There was an interaction between sex and probable parental LOAD for hippocampal volume, with a significant association between probable parental LOAD and hippocampal volume in women. Conclusions: Fully automated MR volumetry can distinguish subjects with SMC and MCI from controls in a general population, but insufficiently to assume a clear clinical role. Research on sporadic LOAD might benefit from a sex-specific search for genetic risk factors.

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“…11,12 Associations between SMD and objective neuropsychological measures have been found to be weak, 13 however, and SMD has low predictive value for dementia. 14 In addition, SMD is linked with anxiety and depression symptomatology, thus making it a less-specific clinical marker and its significance more difficult to interpret, 15,16 although it should be noted that mood disorders are also risk factors for Alzheimer disease (AD). 17 It is therefore possible that the association of SMD with cognitive decline is concurrent to or causally interrelated with its association with affective symptoms.…”

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confidence: 99%

Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study

Cherbuin

Sargent‐Cox

Easteal

et al. 2015

The American Journal of Geriatric Psychiatry

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Subjective memory complaints in community dwelling healthy older people: the influence of brain and psychopathology

Abstract: Both SMC and white matter disease were common. SMC were associated with a history of depression or anxiety but not with white matter disease. Evaluation for a history of depression and anxiety in people with SMC is supported by these findings.

Cited by 39 publications

References 36 publications

The association between subjective memory complaint and objective cognitive function in older people with previous major depression

The association between subjective memory complaint and objective cognitive function in older people with previous major depression

Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors

Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study

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