Subjective impact of osteoarthritis flare-ups on patients' quality of life

Majani, Giuseppina; Giardini, Anna; Scotti, Aurelio

doi:10.1186/1477-7525-3-14

Cited by 21 publications

(16 citation statements)

References 32 publications

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“…Although flare-ups have been studied in both inflammatory 3,4 and non-inflammatory rheumatic disease 5 , little is known about the characteristics of flare-ups of chronic nonspecific back pain (CNSBP). This lack of information is noteworthy, since multiple qualitative studies have confirmed that flare-ups are an important part of the experience of CNSBP for many patients 6–8 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics of Flare-ups of Chronic Nonspecific Back Pain in Primary Care

Suri

Saunders

Korff

2012

The Clinical Journal of Pain

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Objectives To describe the prevalence and characteristics of flare-ups of chronic non-specific back pain (CNSBP) among primary care patients, and to examine associations with measures of pain severity and psychosocial factors. Methods Six hundred and thirty-four subjects with nonspecific back pain were interviewed by telephone 2 years after an initial primary care visit for back pain. Subjects experiencing flare-ups in the last 6 months reported on frequency, duration, and other characteristics of flare-ups. Using bivariate and multivariate analyses, we compared individuals with and without CNSBP flare-ups with respect to demographic characteristics, measures of pain severity, and psychosocial factors. Results 51% of subjects reported flare-ups. Physical activities, including lifting and bending, were the most common perceived triggers of flare-ups. Subjects with flare-ups experienced greater levels of pain intensity, disability, opioid medication use, and psychosocial comorbidities. After adjustment for demographic factors, pain intensity, and pain frequency, subjects with flare-ups were more disabled than those without (mean [95% confidence interval] disability score 4.2 [3.9– 4.4] vs. 3.3 [2.9– 3.6]; p <0.0001) and demonstrated higher levels of passive coping (mean passive coping score 4.1[3.8–4.3] vs. 3.4 [3.1–3.7]; p=0.0008). Discussion Flare-ups of CNSBP are common among primary care patients, and are independently associated with higher levels of pain intensity, disability, and passive coping. The presence of flare-ups and the perception of activity as a trigger may predispose patients with flare-ups to experience disability not explained by pain intensity alone. Further longitudinal studies are required to better characterize CNSBP flare-ups and determine their clinical implications.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics of Flare-ups of Chronic Nonspecific Back Pain in Primary Care

Suri

Saunders

Korff

2012

The Clinical Journal of Pain

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“…The classic version of the VAS was administered: 10-centimeter line, horizontal. VAS on present pain ranged from “no pain” to “the worst pain possible” and VAS on pain relief ranged from “no pain relief” to “the maximum pain relief.” Scores ranged from 0 to 10 [13]. …”

Section: Methodsmentioning

confidence: 99%

Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis

Kaur

Singh

Gupta

2013

Pain Research and Treatment

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Objective. To compare the efficacy and tolerability of etodolac versus etodolac in combination with eperisone in patients of Osteoarthritis knee. Patients and Methods. A prospective, randomized, open label, parallel group, comparative study was conducted in 60 patients of knee OA over a period of 2 months. Thirty patients received etodolac 600 mg once daily and 30 patients received eperisone 50 mg thrice daily in addition to etodolac 600 mg once daily for 8 weeks. Efficacy assessment was done on the basis of improvement in mean scores of spontaneous pain on Visual analog scale (VAS), pain on movement, functional capacity, joint tenderness, swelling, erythema on Likert scale, and patient's overall arthritic condition on a five-point investigator scale at the end of study period as compared with the baseline scores. Assessment of tolerability was done by recording the occurrence of adverse events. Data was analyzed using Chi square test and students t-test. Results. All the enrolled patients completed the study and were compliant to the treatment regimens that they were allocated to. Both the treatment groups showed a statistically significant improvement in all the efficacy parameters at the end of 8 weeks as compared to baseline (P < 0.05) with no statistically significant difference between the groups. Adverse events were few and mild in nature. Conclusion. Combination of etodolac and eperisone is as effective as etodolac alone in patients of OA knee. Thus, it is concluded that additional use of muscle relaxant has no adjuvant value in patients of OA knee and is not recommended. The study is registered with the Clinical Trial Registry of India vide registration number CTRI/2013/03/003442.

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“…The SF-36 [2] [3] [15] is a well-known self-administered and generic health status measure which encompasses 8 domains related to daily life activities and consist of 36 items. Each domain scores from 0 (lowest level of functioning) to 100 (highest level of functioning).…”

Section: Measurement Toolmentioning

confidence: 99%

“…Osteoarthritis (OA) is a chronic disease that has a substantial effect on patients' health related quality of life (HRQoL) as well as an extremely high economic burden usually attributed to the treatment side effects [1]. Activities of daily living are negatively affected in OA patients [2]. Its symptoms are debilitating, and accounting for significant disability characterized as the impaired performance of social and physical life tasks [3] [4].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic use of analgesics and anti-inflammatory drugs can cause dramatic changes on patients' HRQoL & long term plan is definitely important when safety and patients' HRQoL are considered. Previous studies have shown that both NSAIDs and selective COX-2 inhibitors improved patients' HRQoL when compared to the baseline [2] [3] [10] [11]; however very few studies conducted direct comparison between the two medication classes [12]. It is well recognized now that a key outcome measure for any intervention for OA is measuring the changes in HRQoL as for many other conditions [13].…”

Section: Introductionmentioning

confidence: 99%

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Health Related Quality of Life among Osteoarthritis Patients: A Comparison of Traditional Non-Steroidal Anti-Inflammatory Drugs and Selective COX-2 Inhibitors in the United Arab Emirates Using the SF-36

Hassanein¹,

Shamssain²,

Hassan³

2015

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Objectives: Osteoarthritis (OA) has a dramatic impact on patients' health related quality of life (HRQoL). Chronic use of analgesics and anti-inflammatory medications for pain management may improve symptoms but on long term may affect HRQoL negatively. The objective of the present study was to compare the impact of two different classes of analgesics, traditional non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase-2 (COX-2) inhibitors on HRQoL among osteoarthritis patients using the SF-36 questionnaire. Methods: Clinic based cross-sectional study conducted at Al-Qassimi Hospital, Sharjah, United Arab Emirates (UAE), over a period of six months. Ethical Approval was obtained from the ethics committee at Al-Qassimi Clinical Research Center. Total of 200 osteoarthritis patients fulfilling the inclusion and exclusion criteria were involved in the study. Patients' demographics were collected from their medical records. The Medical Outcome Study Short-Form 36 (SF-36) questionnaire was used to measure patients' HRQoL. SF-36 data were scored using health outcomes scoring software 4.5. Results: Mean age of the subjects was 62.19 ± 9.81 years with females constituting 151 (75.5%) of the patients. In general, females scored lower in most of the HRQoL domains compared to males and there was significant difference between the two groups in the mental health (p = 0.005) & mental component (p = 0.042) domains. Compared to selective COX-2 inhibitors, patients on NSAIDs scored higher on all domains of SF-36 except physical functioning. There was significant difference in mental health * Corresponding author. M. Hassanein et al. 233 domain for patients treated with NSAIDs (p = 0.02). Celecoxib was only better than NSAIDs in osteoarthritis patients with more than one musculoskeletal disorders in the domain of bodily pain (p = 0.009). Conclusion: NSAIDs-treated patients did not differ significantly from celecoxib-treated patients in all domains of the SF-36 except for the mental health domain.

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Subjective impact of osteoarthritis flare-ups on patients' quality of life

Cited by 21 publications

References 32 publications

Prevalence and Characteristics of Flare-ups of Chronic Nonspecific Back Pain in Primary Care

Prevalence and Characteristics of Flare-ups of Chronic Nonspecific Back Pain in Primary Care

Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis

Health Related Quality of Life among Osteoarthritis Patients: A Comparison of Traditional Non-Steroidal Anti-Inflammatory Drugs and Selective COX-2 Inhibitors in the United Arab Emirates Using the SF-36

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