Because Tire not only impact on the handling stability of vehicle but also impact on the ride comfort, it is more practical significant that tire vertical stiffness parameters on handling stability and ride of vehicle impact is considered synthetically than considering handling stability and ride singly. In this paper, full vehicle model was built on the basis of ADAMS/Car. The vertical stiffness of tire was only changed and other parameters remain unchanged, then full vehicle analysis was carried out to get the simulation curves. The impact of the vertical stiffness of tires on the handling and stability and ride comfort was obtained from the curves of simulation. The tires of optimized vertical stiffness can be obtained from the comparison of simulation results. Analytical results can be conductive to designing and producing the tire.