Subjective cognitive impairment and its relationship to sleep impairment, anxiety severity, and depressive symptoms in individuals with bipolar disorder

Siegel-Ramsay, Jennifer E.; Wu, Bryan; Bond, Mark; David, Sergio; Chiang, Karl S.; Scalea, Teresa Lanza di; Collier, Sam J.; Smith, Tawny; Nunez, Leyna; Fuller, Ersten; Strakowski, Stephen M.; Lippard, Elizabeth; Almeida, Jorge

doi:10.1016/j.jadr.2022.100442

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…In agreement with other studies (Marvel and Paradiso 2004;Bora et al 2013;Siegel-Ramsay et al 2022), participants also reported cognitive impairments, which may further exacerbate employment difficulties. Cognitive impairment may be associated with medication side effects, residual depressive symptoms or neurocognitive decline (Marwaha et al 2013;Kim et al 2018;Lu et al 2022).…”

Section: Improving Capability By Supporting and Maintaining Employmen...supporting

confidence: 92%

Experiences that matter in bipolar disorder: a qualitative study using the capability, comfort and calm framework

Siegel-Ramsay

Sharp

Ulack

et al. 2023

Int J Bipolar Disord

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Background When assessing the value of an intervention in bipolar disorder, researchers and clinicians often focus on metrics that quantify improvements to core diagnostic symptoms (e.g., mania). Providers often overlook or misunderstand the impact of treatment on life quality and function. We wanted to better characterize the shared experiences and obstacles of bipolar disorder within the United States from the patient’s perspective. Methods We recruited 24 individuals diagnosed with bipolar disorder and six caretakers supporting someone with the condition. Participants were involved in treatment or support services for bipolar disorder in central Texas. As part of this qualitative study, participants discussed their everyday successes and obstacles related to living with bipolar disorder during personalized, open-ended interviews. Audio files were transcribed, and Nvivo software processed an initial thematic analysis. We then categorized themes into bipolar disorder-related obstacles that limit the patient’s capability (i.e., function), comfort (i.e., relief from suffering) and calm (i.e., life disruption) (Liu et al., FebClin Orthop 475:315–317, 2017; Teisberg et al., MayAcad Med 95:682–685, 2020). We then discuss themes and suggest practical strategies that might improve the value of care for patients and their families. Results Issues regarding capability included the struggle to maintain identity, disruptions to meaningful employment, relationship loss and the unpredictable nature of bipolar disorder. Comfort related themes included the personal perception of diagnosis, social stigma and medication issues. Calm themes included managing dismissive doctors, finding the right psychotherapist and navigating financial burdens. Conclusions Qualitative data from patients with bipolar disorder helps identify gaps in care or practical limitations to treatment. When we listen to these individuals, it is clear that treatments must also address the unmet psychosocial impacts of the condition to improve patient care, capability and calm.

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Section: Improving Capability By Supporting and Maintaining Employmen...supporting

confidence: 92%

Experiences that matter in bipolar disorder: a qualitative study using the capability, comfort and calm framework

Siegel-Ramsay

Sharp

Ulack

et al. 2023

Int J Bipolar Disord

View full text Add to dashboard Cite

show abstract

“…Interestingly, these relationships are dynamic, whereby increases in symptom severity distinct to mood and metabolic disorders are associated with greater cognitive decline (Karlsson, Gatz, Arpawong, Dahl Aslan, & Reynolds, 2021;Marvel & Paradiso, 2004). Understanding these interactions is of great importance due to the impact of cognitive function on symptom severity and functioning in individuals with mood disorders (Burdick, Goldberg, & Harrow, 2010;Siegel-Ramsay et al, 2022). A recent meta-analysis examined the association between depression and cognition in persons with diabetes mellitus and reported significant impairment in overall cognition, executive function, language, and memory among individuals with comorbid diabetes and depression in comparison to those with only diabetes (Chow, Verdonschot, McEvoy, & Peeters, 2022).…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis

Maksyutynska,

Stogios,

Prasad

et al. 2024

Psychol. Med.

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Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index ⩾25 kg/m2, and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.

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Functional assessment short test (FAST): Self-administration in outpatient mental health settings

Siegel-Ramsay

Kapczinski

et al. 2023

Journal of Psychiatric Research

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Subjective cognitive impairment and its relationship to sleep impairment, anxiety severity, and depressive symptoms in individuals with bipolar disorder

Cited by 3 publications

References 36 publications

Experiences that matter in bipolar disorder: a qualitative study using the capability, comfort and calm framework

Experiences that matter in bipolar disorder: a qualitative study using the capability, comfort and calm framework

Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis

Functional assessment short test (FAST): Self-administration in outpatient mental health settings

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