Subjective Cognitive Decline and Related Cognitive Deficits

Si, Tong; Xing, Guoqiang; Han, Ying

doi:10.3389/fneur.2020.00247

Cited by 51 publications

(44 citation statements)

References 110 publications

(69 reference statements)

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“…However, it is important to note that both brain activity and FC significantly decreased as early as in SCD. This suggests that dysregulation of brain neuronal excitability appears before objective impairment upon formal testing and that might be a potential biomarker (Mattson and Arumugam, 2018 ; Si et al, 2020 ). Interestingly, the FC strength between LPCUN and the altered regions of the brain in the AD group showed an increasing trend compared to the SCD and MCI groups.…”

Section: Discussionmentioning

confidence: 99%

Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

Zhang

Wang

et al. 2021

Front. Aging Neurosci.

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Objective: To investigate variation in the characteristics of regional cerebral blood flow (rCBF), brain activity, and intrinsic functional connectivity (FC) across the Alzheimer's disease spectrum (ADS).Methods: The study recruited 20 individuals in each of the following categories: Alzheimer's disease (AD), mild cognitive impairment (MCI), subjective cognitive decline (SCD), and healthy control (HC). All participants completed the 3.0T resting-state functional MRI (rs-fMRI) and arterial spin labeling scans in addition to neuropsychological tests. Additionally, the normalized CBF, regional homogeneity (ReHo), and amplitude of low-frequency fluctuation (ALFF) of individual subjects were compared in the ADS. Moreover, the changes in intrinsic FC were investigated across the ADS using the abnormal rCBF regions as seeds and behavioral correlations. Finally, a support-vector classifier model of machine learning was used to distinguish individuals with ADS from HC.Results: Compared to the HC subjects, patients with AD showed the poorest level of rCBF in the left precuneus (LPCUN) and right middle frontal gyrus (RMFG) among all participants. In addition, there was a significant decrease in the ALFF in the bilateral posterior cingulate cortex (PCC) and ReHo in the right PCC. Moreover, RMFG- and LPCUN-based FC analysis revealed that the altered FCs were primarily located in the posterior brain regions. Finally, a combination of altered rCBF, ALFF, and ReHo in posterior cingulate cortex/precuneus (PCC/PCUN) showed a better ability to differentiate ADS from HC, AD from SCD and MCI, but not MCI from SCD.Conclusions: The study demonstrated the significance of an altered rCBF and brain activity in the early stages of ADS. These findings, therefore, present a potential diagnostic neuroimaging-based biomarker in ADS. Additionally, the study provides a better understanding of the pathophysiology of AD.

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Section: Discussionmentioning

confidence: 99%

Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

Zhang

Wang

et al. 2021

Front. Aging Neurosci.

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“…Epidemiological studies have shown that the prevalence of SCD ranges from 10 to 88% and increases with age: 20% in people 65 years and younger, 25-50% in people 65 years and older, and 88% in people over 85 years of age (Gifford et al, 2015). For SCD, memory decline is the most common symptom, and at the same time it can be accompanied by visual-spatial impairment, language impairment, attention deficit, and other symptoms (Si et al, 2020). According to statistics, an estimated 27% of SCD patients will develop MCI in the future, and another 14% will eventually be diagnosed with cognitive impairment (Mitchell et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Subjective Cognitive Decline May Be Associated With Post-operative Delirium in Patients Undergoing Total Hip Replacement: The PNDABLE Study

Liu

Wang

et al. 2021

Front. Aging Neurosci.

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Objective: Subjective cognitive decline (SCD) is associated with an increased risk of clinical cognitive disorders. Post-operative delirium (POD) is a common complication after total hip replacement. We aimed to investigate the relationship between SCD and POD in patients undergoing total hip replacement.Methods: Our study recruited 214 cognitively intact individuals from the Perioperative Neurocognitive Disorder And Biomarker Lifestyle (PNDABLE) study in the final analysis. SCD was diagnosed with Subjective Cognitive Decline Scale (SCDS), Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). The incidence of POD was evaluated by using Confusion Assessment Method (CAM), and POD severity was measured by using the Memorial Delirium Assessment Scale (MDAS). Preoperative cerebrospinal fluid (CSF) Aβ40, Aβ42, T-tau, and P-tau levels were measured by enzyme-linked immune-sorbent assay (ELISA).Results: Overall, the incidence of POD was 26.64% (57/214), including 32.43% (36/111) in the SCD group and 20.39% (21/103) in the NC group. With the increase of age, the incidence of POD in all age groups increased (P < 0.05). Logistic regression analysis showed that after adjusting for SCD, Aβ42, Aβ40, P-tau, and T-tau, SCD (OR 2.32, CI 1.18–4.55, P = 0.01) and the increased CSF level of P-tau (OR 1.04, CI 1.01–1.06, P < 0.001) were risk factors for POD, while the level of aβ42 (OR 0.99, CI 0.99–1.00, P < 0.001) was a protective factor for POD.Conclusion: SCD is one of the preoperative risk factors for POD.Clinical Trial Registration: This study was registered at China Clinical Trial Registry (Chictr200033439).

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“…Third, our subjective cognitive complaint questionnaire has not been validated. In fact, validated tools for evaluating subjective cognitive decline are still under development 66 . We attempted to use a comprehensive questionnaire as an exploratory tool to measure subjective cognitive complaints, correlations to the cognitive problems of SSS, and objective cognitive performance (Supplementary Tables S4 and S5 ) in our study, which may support the validity of our subjective cognitive complaint questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Salivary cortisol is associated with cognitive changes in patients with fibromyalgia

Lin

Chow

et al. 2021

Sci Rep

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Fibromyalgia (FM) is a stress-related chronic pain disorder with common cognitive complaints. This study characterized cognitive dysfunction in patients with FM and explored whether these changes are linked to altered cortisol levels. Consecutive 44 patients with FM and 48 healthy controls were enrolled for the assessments of subjective and objective cognitive functions and diurnal levels of salivary cortisol (sampled at awakening, 30 min after awakening, 3 pm, and bedtime). All measurements were compared between the groups and evaluated for clinical correlation. The FM group had more subjective cognitive complaints and performed poorer in objective cognitive testing in memory (delayed recall in Chinese Version Verbal Learning Test and Taylor Complex Figure Test), language (Boston Naming Test), and executive domains (Wisconsin Card Sorting Test) after adjustments for education. The diurnal cortisol levels of patients with FM tended to be lower, especially at 30 min after awakening and bedtime. Moreover, moderate positive correlations existed between the Chinese Version Verbal Learning Test, Boston Naming Test and the morning cortisol levels within the FM group. We suggested the altered cognitive function in FM may be linked to stress maladaptation. Future studies are warranted to elucidate whether stress management improves cognitive performance in patients with FM.

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Subjective Cognitive Decline and Related Cognitive Deficits

Cited by 51 publications

References 110 publications

Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

Subjective Cognitive Decline May Be Associated With Post-operative Delirium in Patients Undergoing Total Hip Replacement: The PNDABLE Study

Salivary cortisol is associated with cognitive changes in patients with fibromyalgia

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