Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls

Cui, Xiaoxi; Liu, Jianru; Xiao, Wu; Chu, Yi; Ouyang, Xiangying

doi:10.1016/j.archoralbio.2019.02.012

Cited by 17 publications

(11 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…is in agreement with a recent study on GAgP (Schulz et al, 2019). (Cui et al, 2019). In contrast, sites from successfully treated patients in the present study exhibited higher levels of A. graevenitzii, C. sputigena, Rothia mucilaginosa, H. parainfluenzae and L. mirabilis (Figure 3b).…”

Section: Discussionsupporting

confidence: 94%

“…This study shows, for the first time, clear differences in the subgingival microbiota between patients with persistent GAgP and patients considered “successfully treated.” Patients with ongoing disease had a more diverse microbiota, compatible with increased dysbiosis, in agreement with previous studies which seem to suggest that increased microbial diversity at subgingival level is associated with disease (Cui, Liu, Xiao, Chu, & Ouyang, 2019; Dabdoub, Tsigarida, & Kumar, 2013; Sousa et al., 2017). More specifically, different bacterial species can be mapped according to the material and methods employed (Schulz et al., 2019) and these differences warrant further investigation.…”

Section: Discussionsupporting

confidence: 91%

“…, Porphyromonas gingivalis, Tannerella forsythia, Porphyromonas endodontalis, Peptostreptococcaceae spp. , Parvimonas micra, Eubacterium nodatum and Eubacterium saphenum as increased in AgP cases (Cui et al., 2019). In contrast, sites from successfully treated patients in the present study exhibited higher levels of A. graevenitzii, C. sputigena, Rothia mucilaginosa, H. parainfluenzae and L. mirabilis (Figure 3b).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis

Nibali

Sousa

Davrandi

et al. 2020

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis

Nibali

Sousa

Davrandi

et al. 2020

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…Four of the 17 bacteria taxa shown to be decreased in the GERD patients who did not use PPI compared to controls, Porphyromonas gingivalis, Filifactor alocis, Fretibacterium fastidiosum, and Lachnospiraceae_ [G-8];s_ [G-8]_bac-terium_HMT_500, have been found to be elevated in the saliva and/or periodontia of patients with chronic or aggressive periodontitis ( Fig. 3) [33][34][35] . This is consistent with the recent findings that GERD patients have lower risk for periodontal disease 36 .…”

Section: Discussionmentioning

confidence: 99%

Salivary microbiome with gastroesophageal reflux disease and treatment

Kawar

Park

Schwartz

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased acidity in the oral cavity resulting in dental erosion, and controversially a reduced risk of periodontal disease. We hypothesized that presence of GERD was linked to a modified microbial profile in untreated GERD patients and that the use of proton pump inhibitor (PPI) drugs: potent disruptors of gut microbiome, in GERD patients might result in a salivary microbiome that is further distinct. Untreated GERD patients showed multiple differences in salivary microbiome as compared to healthy controls. Taxa found at lower levels related to the presence of GERD not treated by PPI included: Prevotella melaninogenica, Prevotella pallens, Leptotrichia, and Solobacterium moorei and thirteen others. In contrast, GERD patients chronically using PPI showed minimal differences in salivary taxa compared to healthy controls not using PPI.

show abstract

“…were signi cantly higher in individuals with ID. Some studies have reported a strong association between T. forsythia and periodontitis [31]. Bloch et al have reported the existence of an S-layer, which is the surface layer of T. forsythia [32].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Oral Hygiene Status and Relative Abundance of Periodontal Pathogens Between Individuals With and Without Intellectual Disabilities: a Cross-Sectional Study

Oda

Furutani

Kawano

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Studies have reported a high prevalence of periodontal disease in individuals with intellectual disability (ID). The aim of this study was to compare the relative abundance of periodontal pathogens (red, orange, yellow, purple, and green complexes) between individuals with ID and healthy controls.Methods: Of the 31 subjects enrolled in this study, 16 with severe ID were selected from the outpatient clinic of the Special Care Dentistry of Hiroshima University Hospital, and 14 healthy subjects were selected from the outpatient clinic of another department at the same hospital. Dental plaque was sampled after oral examination. Decayed, missing, and filled permanent teeth (DMFT) counts were obtained and periodontal measurements were taken using the papillary-marginal-attached (PMA) index, plaque index (PI), gingival index (GI), and probing depth (PD). Gene sequencing (16S rRNA) was performed for each sample using next-generation high-throughput sequencing methods. The relative abundance of the periodontal pathogens and the clinical parameters were compared. An unpaired t-test was used to compare the oral health status in both groups and analysis of covariance was performed to compare the relative abundance of each pathogen.Results: No statistically significant difference in DMFT was observed between the two groups. However, significant differences in the median PMA index, PI, and GI were noted between the groups (P < 0.0001). In addition, the mean PD in the ID group was significantly higher than that in the control group (P < 0.0001). The relative abundances of Tannerella spp. and Treponema spp. were significantly higher in the ID group when compared to the control group at the genus level (P = 0.0383 and 0.0432, respectively); alternatively, the relative abundance of Porphyromonas spp. was significantly lower in the ID group (P < 0.0001).Conclusions: The PMA index, PI, GI, and PD were significantly lower in the ID group than in the control group. On the other hand, no significant difference in DMFT was observed between the two groups. Furthermore, our findings indicate that Tannerella forsythia might be more closely associated with periodontal disease than Porphyromonas gingivalis in individuals with ID.

show abstract

Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls

Cited by 17 publications

References 45 publications

Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis

Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis

Salivary microbiome with gastroesophageal reflux disease and treatment

Comparison of Oral Hygiene Status and Relative Abundance of Periodontal Pathogens Between Individuals With and Without Intellectual Disabilities: a Cross-Sectional Study

Contact Info

Product

Resources

About