Subgingival Microbial Profiles of Smokers with Periodontitis

Shchipkova, A.Y.; Nagaraja, Haikady N.; Kumar, Purnima

doi:10.1177/0022034510377203

Cited by 223 publications

(247 citation statements)

References 34 publications

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“…16,17,18,19,20 However, other authors have not found this association. 21,22,23 It has also been shown that smokers have less favorable responses to non-surgical and surgical periodontal therapy than nonsmokers.…”

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confidence: 90%

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

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The aim of this study was to perform a systematic review and meta-analysis to examine the effect of systemic antibiotics in the periodontal treatment of smokers. The selection criteria were as follows: controlled randomized clinical trials; studies published in English; studies with smoker patients diagnosed with chronic periodontitis; patients without systemic diseases; studies that used systemic antibiotic therapy associated with periodontal treatment; studies that presented results for the test and control groups and assessments of clinical periodontal parameters, such as probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). The differences in average weights were calculated with a confidence interval (CI) of 95% for PD reduction, CAL gain and BOP. The means of the periodontal clinical parameters were compared between the baseline and post-treatment periods between the test groups and the control groups. The heterogeneity was assessed using the Cochran Q test (Q (df = 3), α = 5%). A total of 67 articles were found, and after the selection process, three randomized controlled trials were included in the meta-analysis. The results indicate that SRP associated with systemic antibiotics promoted additional benefits when compared to SRP alone, with a greater reduction of PD (p = 0.0359, CI = -0.42, -0.01) and a gain of CAL (p = 0.0161, CI = -0.39, -0.04). There was a modest PD reduction (PD, DM -0.21) and a modest CAL gain (CAL, DM -0.22). The results of our meta-analysis reveal the clinical benefits of systemic antibiotics as an adjunct to the non-surgical periodontal treatment of smokers. These clinical improvements, although statistically significant, appeared to be of little clinical relevance.

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confidence: 90%

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

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“…Studies have found alterations in the oral microbiome in smokers compared with nonsmokers, with increases in some species and decreases in others (45,46). A recent study from the Lung HIV Microbiome Program found that oral microbial composition differed significantly by smoking status, but BAL communities in smokers and nonsmokers…”

Section: The Role Of Smokingmentioning

confidence: 99%

Heart–Lung Interaction via Infection

Morris

2014

Annals ATS

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Lung and cardiovascular disease are increasingly recognized to occur in the same patient populations. Infections, either through stimulation of inflammation or through direct infection, can lead to end-organ damage and have been postulated as a potential link between lung and cardiovascular diseases. Mechanisms by which infections may link lung and cardiac diseases include effects of systemic infections, microbial translocation of pathogens from the gastrointestinal tract or other sites, damaging effects of metabolic products, or influences of smoking on the microbiome.Other mechanisms, such as alterations in the local microbiome, environmental exposures, or immune regulation by microbial communities, may be important. These relationships are likely quite complex, with multiple routes between infection and disease possible. A better understanding of the links of infection to lung and heart disease can improve our understanding of the pathogenesis of these disorders and uncover novel therapeutic approaches.Keywords: microbial translocation; metabolomics; pulmonary function; cardiovascular; HIV Correspondence and requests for reprints should be addressed to Alison Morris, M.D., M.S.,

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“…The polymerase chain reaction (PCR) is a more sensitive and specific method for the detection of bacteria than conventional culture-based methods. A series of recent studies (Preshaw et al, 2005b;Delima et al, 2010;Shchipkova et al, 2010) revealed a bacteriological mechanism by using a novel method for bacterial identification. The microbial profile of disease-associated and health-compatible organisms in smokingassociated periodontitis patients was significantly different from that in non-smokers.…”

Section: Biological Plausibilitymentioning

confidence: 99%