Subgingival distribution of Campylobacter rectus and Tannerella forsythensis in healthy children with primary dentition

Hayashi, Fumiko; Okada, Morihiko; Soda, Yoshinori; Miura, Kazuo; Kozai, Katsuyuki

doi:10.1016/j.archoralbio.2005.05.004

Cited by 13 publications

(13 citation statements)

References 28 publications

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“…The high detection rate of C. rectus in the present study agrees with the result of Hayashi et al . (26) . In the present study, P. nigrescens was detected in 38.5% of the children.…”

Section: Discussionsupporting

confidence: 52%

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Colonization pattern of periodontal bacteria in Japanese children and their mothers

Kobayashi¹,

Ishihara²,

Sugihara

et al. 2007

J of Periodontal Research

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Background and Objective: The purpose of this study was to determine the time of infection by anaerobic gram‐negative rods associated with periodontal disease, and to clarify their transmission from mother to child. Material and Methods: Seventy‐eight Japanese children (including 10 siblings), aged from 3 to 9 years, and 68 mothers, were enrolled in this study. Colonization by 11 periodontal bacterial species was determined using polymerase chain reaction amplification of samples of subgingival plaque obtained from the children and their mothers. Results: The detection rates of Porphyromonas gingivalis, Tannerella forsythensis and Treponema denticola increased in children after the age of 6 years. We found a high consistency in colonization by P. gingivalis, T. denticola, Prevotella intermedia and Prevotella nigrescens in 9 of the 10 siblings. The average number of bacterial species in plaque samples harboring Fusobacterium nucleatum and/or Fusobacterium periodonticum was significantly greater than in those without, in both children and mothers. Kappa statistical analysis revealed that the detection of Capnocytophaga gingivalis, Capnocytophaga ochracea, Campylobacter rectus and T. denticola in children was consistent with that in the mother. Conclusion: Periodontal bacterial colonization in Japanese children increased with age and was associated with F. nucleatum and/or periodonticum, and the bacterial flora in children was similar to that in their mothers.

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“…The high detection rate of C. rectus in the present study agrees with the result of Hayashi et al . (26) . In the present study, P. nigrescens was detected in 38.5% of the children.…”

Section: Discussionsupporting

confidence: 52%

“…Hayashi et al . (26) reported that of 10 children aged 4–6 years with complete primary dentition, all were positive for C. rectus , and that the rate of positive sites was 17.6 ± 2.4%. The high detection rate of C. rectus in the present study agrees with the result of Hayashi et al .…”

Section: Discussionmentioning

confidence: 99%

Colonization pattern of periodontal bacteria in Japanese children and their mothers

Kobayashi¹,

Ishihara²,

Sugihara

et al. 2007

J of Periodontal Research

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“…It is clear that levels of gram-negative periodontal pathogens increase with age, although studies of young humans and nonhuman primates demonstrate that many microorganisms associated with periodontal pathogenesis are acquired early in life and become integrated into the commensal autochthonous oral microbial ecology (9,29,30,56). However, it remains unclear how the age of the host impacts recognition of and response to these oral microorganisms.…”

mentioning

confidence: 94%

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Ebersole

Steffen

González‐Martínez

et al. 2008

Clin Vaccine Immunol

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This report evaluated systemic inflammatory and immune biomarkers in a cohort of Macaca mulatta (rhesus monkeys) maintained as a large family social unit, including an age range from <1 year to >24 years. We hypothesized that the systemic host responses would be affected by the age, gender, and clinical oral presentation of the population, each contributing to inflammatory and immune responses that would reflect chronic oral infections. The results demonstrated that the prevalence and severity of periodontitis, including missing teeth, increased significantly with age. Generally, minimal differences in clinical parameters were noted between the genders. Systemic inflammatory mediators, including acute-phase reactants, prostaglandin E 2 (PGE 2 ), cytokines/chemokines, and selected matrix metalloproteinases (MMP), demonstrated significant differences among the various age groups of animals. Levels of many of these were increased with age, although PGE 2 , RANTES, bactericidal permeability-inducing factor (BPI), MMP-1, and MMP-9 levels were significantly increased in the young group (ϳ1 to 3 years old) relative to those for the older animals. We observed that in the adult and aged animals, levels of the systemic inflammatory mediators related to gingival inflammation and periodontal tissue destruction were significantly elevated. Serum antibody levels in response to a battery of periodontal pathogens were generally lower in the young animals, <50% of those in the adults, and were significantly related to aging in the cohort. The levels of antibodies, particularly those to Porphorymonas gingivalis, Fusobacterium nucleatum, and Tannerella forsythia, were most significantly elevated in animals with periodontal disease, irrespective of the age of the animal. These results provide a broad description of oral health and host responses in a large cohort of nonhuman primates from very young animals to the aged of this species. The findings afford a base of data with which to examine the ontogeny of host responses at mucosal sites, such as the gingival tissues.Periodontal disease is the predominant chronic inflammatory disease of humanity (37,38,78,82) and has been noted to occur naturally with increasing age in humans and nonhuman primates (36,63,69,88). This oral disease is an outcome of complex oral infections, chronic immunoinflammatory responses, and resulting destruction of soft and hard tissues of the periodontium (37,78,80,82,84). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (48), environmental stressors (6, 76, 85), and the genetic backgrounds of the individuals (3, 70, 84).The oral microbial characteristics of subgingival biofilms in younger and older individuals demonstrate differences in composition and complexity, which have been suggested to contribute directly to the microbial infections that trigger the destructive disease of oral tissues that occurs during aging (4,35,49,...

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“…Nevertheless, the detailed characteristics of this microbial acquisition remain speculative, and minimal information is available regarding the development of host responses to this oral colonization in young individuals. It does appear that these bacteria that are acquired early in life become integrated into the commensal autochthonous oral microbial ecology within the individual (43)(44)(45)(46).…”

mentioning

confidence: 99%

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

Ebersole

Holt

Delaney

2013

Clin. Vaccine Immunol.

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The acquisition and development of the complex oral microbiome remain ill defined. While selected species of oral bacteria have been examined in relation to their initial colonization in neonates, a more detailed understanding of the dynamics of the microbiome has been developed only in adults. The current investigation used a nonhuman primate model to document the kinetics of colonization of the oral cavities of newborns and infants by a range of oral commensals and pathogens. Differences in colonization were evaluated in newborns from mothers who were maintained on an oral hygiene regimen pre-and postparturition with those displaying naturally acquired gingivitis/periodontitis. The results demonstrate distinct profiles of acquisition of selected oral bacteria, with the transmission of targeted pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, being passed on primarily from mothers with gingivitis/periodontitis. This colonization resulted in defined patterns of systemic antibody responses in the infants. The significant relative risk measures for infection with the pathogens, as well as the relationship of oral infection and blood serum antibody levels, were consistent with those of the newborns from mothers with gingivitis/periodontitis. These findings indicate that the early acquisition of potentially pathogenic oral bacterial species might impact the development of mucosal responses in the gingiva and may provide an enhanced risk for the development of periodontitis later in life.

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Subgingival distribution of Campylobacter rectus and Tannerella forsythensis in healthy children with primary dentition

Cited by 13 publications

References 28 publications

Colonization pattern of periodontal bacteria in Japanese children and their mothers

Colonization pattern of periodontal bacteria in Japanese children and their mothers

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

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