Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts

Jahn, Allison L.; Fox, Andrew S.; Abercrombie, Heather C.; Shelton, Steven E.; Oakes, Terrence R.; Davidson, Richard J.; Kalin, Ned H.

doi:10.1016/j.biopsych.2009.07.039

Cited by 57 publications

(44 citation statements)

References 51 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, increased activation was found in the BNST as well as the amygdala specifically in uncertain social threat conditions in Rhesus monkeys carrying the homolog of the human s-allele . Moreover, human s-allele carriers had increased anterior cingulate activity that was associated with a profound effect on cortisol secretion-especially to social threat (Jahn, Fox, Abercrombie, Shelton, Oakes, Davidson, & Kalin, 2010;Way & Taylor, 2010). Finally, the s-allele is also associated with reduced gray matter volume in the human amygdala, which may reflect reduced dendritic branching and axonal arborization (Hariri, 2006;Pezawas et al, 2005).…”

Section: Polymorphism Of the Serotonin Transporter Gene And Anxiety/smentioning

confidence: 96%

Modeling Borderline Personality Disorder Based on the Neurobehavioral Foundation of Major Personality Traits

Depue¹,

Fu²

2012

Psychodynamic Psychiatry

View full text Add to dashboard Cite

Borderline personality disorder (BPD) is an exceedingly complex behavioral phenomenon that is in need of conceptual clarification within a larger model of personality disorders (PDs). The association of personality traits to BPD is discussed initially as a means of introducing a dimensional personality approach to understanding BPD. While this model suggests that PDs emerge at the extremes of personality dimensions, attempts to demonstrate such an association have been empirically disappointing and conceptually unilluminating. Therefore, in this article, we attempt to extend such models by outlining the neurobehavioral systems that underlie major personality traits, and highlight the evidence that they are subject to experience-dependent modification that can be enduring through effects on genetic expression, mainly through processes known as epigenetics. It is through such processes that risk for personality disorder may be modified by experience at any point in development, but perhaps especially during early critical periods of development. We conclude by presenting a multidimensional model of PDs, in general, and BPD, in particular, that relies on the concepts developed earlier in the article. Our goal is to provide a guide for novel clinical conceptualization and assessment of PDs, as well as research on their psychobiological nature and pharmacological treatment.

show abstract

Section: Polymorphism Of the Serotonin Transporter Gene And Anxiety/smentioning

confidence: 96%

Modeling Borderline Personality Disorder Based on the Neurobehavioral Foundation of Major Personality Traits

Depue¹,

Fu²

2012

Psychodynamic Psychiatry

View full text Add to dashboard Cite

show abstract

“…The medial prefrontal cortex (mPFC) has been of particular interest because subregions of the mPFC show marked changes in neural activity in depressed patients compared to healthy controls. For instance, the ventral mPFC (vmPFC) of MDD patients exhibits increased cerebral blood flow (Drevets et al , 1992) and metabolism (Mayberg, 1997), while the subgenual anterior cingulate cortex (sgACC) (Drevets et al , 1997; Jahn et al , 2010; Ongür et al , 1998; van Tol et al , 2010), shows increases in glucose metabolism in depression (Drevets et al , 1997, 2008) that normalize with successful antidepressant treatment, including deep-brain stimulation near this area (Mayberg et al , 2000, 2005). In addition, responders to acute sleep deprivation exhibited decreased activity in the ventral (including subgenual) region of the anterior cingulate cortex (Clark et al , 2006).…”

Section: Introductionmentioning

confidence: 99%

Ventromedial prefrontal cortex regulates depressive-like behavior and rapid eye movement sleep in the rat

et al. 2014

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a debilitating disease with symptoms like persistent depressed mood and sleep disturbances. The prefrontal cortex (PFC) has been implicated as an important structure in the neural circuitry of MDD, with pronounced abnormalities in blood flow and metabolic activity in PFC subregions, including the subgenual cingulate cortex (sgACC, or Brodmann area 25). In addition, deep brain stimulation in the sgACC has recently been shown to alleviate treatment-resistant depression. Depressed patients also show characteristic changes in sleep: insomnia, increased rapid-eye-movement (REM) sleep and shortened REM sleep latency. We hypothesized that sleep changes and depressive behavior may be a consequence of the abnormal PFC activity in MDD. The rat ventromedial PFC (vmPFC, prelimbic and infralimbic cortices) is considered to be the homolog of the human sgACC, so we examined the effect of excitotic lesions in the vmPFC on sleep-wake and depressive behavior. We also made lesions in the adjacent dorsal region (dmPFC) to compare the effect of this similar but distinct mPFC region. We found that both dmPFC and vmPFC lesions led to increased REM sleep, but only vmPFC-lesioned animals displayed increased sleep fragmentation, shortened REM latency and increased immobility in the forced swim test. Anatomic tracing suggests that the mPFC projects to the pontine REM-off neurons that interact with REM-on neurons in the dorsal pons. These results support our hypothesis that neuronal loss in the rat vmPFC resembles several characteristics of MDD and may be a critical area for modulating both mood and sleep.

show abstract

“…those assessed by the nEO PR-r). Human s allele carriers have also been found to have increased anterior cingulate activity, especially in response to social threat (Jahn et al 2010;Way and taylor 2010). this reactivity was associated with greatly increased cortisol secretion.…”

Section: Serotonin Transporter Imaging and Post-mortem Studies Of Suimentioning

confidence: 97%

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Boulougouris

Malogiannis

Lockwood³

et al. 2013

Exp Brain Res

View full text Add to dashboard Cite

show abstract

Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts

Cited by 57 publications

References 51 publications

Modeling Borderline Personality Disorder Based on the Neurobehavioral Foundation of Major Personality Traits

Modeling Borderline Personality Disorder Based on the Neurobehavioral Foundation of Major Personality Traits

Ventromedial prefrontal cortex regulates depressive-like behavior and rapid eye movement sleep in the rat

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Contact Info

Product

Resources

About