Subfoveal Choroidal Thickness and Cataract: The Beijing Eye Study 2011

Shao, Lei; Xu, Liang; Zhang, Jing Shang; You, Qi Sheng; Chen, Chang Xi; Wang, Ya Xing; Jonas, Jost B.; Wei, Wen Bin

doi:10.1167/iovs.14-15736

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…At last, a detail ophthalmic examination was preformed including spectral domain optical coherence tomography (SD-OCT; Spectralis, Wavelength: 870 nm; Heidelberg Engineering Co., Heidelberg, Germany) with enhanced depth imaging (EDI) modality on the fovea and fundus photographs of central fundus after pupil dilation. All measuring items and methods can be seen in the references 12,13 .…”

Section: Methodsmentioning

confidence: 99%

“…After the landmark study by Spaide and colleagues who described the technical possibility to visualize the choroid and measure its thickness by using the enhanced depth imaging mode of spectral-domain optical coherence tomography (EDI SD-OCT) 8 , several studies using this method have report the subfoveal choroidal thickness (SFCT) in normal subjects and patients with choroidal or retinal diseases [9][10][11][12] . Because the referral bias in hospital-based study is inevitable, our study measured the subfoveal choroidal thickness in a population-based research which recruit a relatively study sample; and reveal that whether hypertension as systemic disease, and hypertensive retinopathy as ocular disease, especially different stages of hypertensive retinopathy is associated with an abnormal thickness of the subfoveal choroid.…”

Section: The Relationship Between Subfoveal Choroidal Thickness and Hmentioning

confidence: 99%

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The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy

Shao

Zhou

et al. 2021

Sci Rep

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The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having hypertensive retinopathy. For the hypertensive cases, the SFCT in patients with hypertensive retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without hypertensive retinopathy (187.04 ± 78.80 µm, P < 0.001). SFCT was significantly associated with the stage of hypertensive retinopathy (P < 0.001), but not significantly associated with diastolic blood pressure (P = 0.94), history (P = 0.95) and years (P = 0.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, hypertensive retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of hypertensive retinopathy.

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Section: Methodsmentioning

confidence: 99%

Section: The Relationship Between Subfoveal Choroidal Thickness and Hmentioning

confidence: 99%

The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy

Shao

Zhou

et al. 2021

Sci Rep

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“…Monoscopic photographs of the macula and optic disc were taken using a fundus camera (Type CR6-45NM, Canon Inc. U.S.A.). The degree of cataract was determined using the standardized lens photographs as described recently [ 13 ]. Diabetic retinopathy was diagnosed on the fundus photographs [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

et al. 2015

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PurposeTo measure the distance between the optic disc center and the fovea (DFD) and to assess its associations.MethodsThe population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals aged 50+ years. The DFD was measured on fundus photographs.ResultsReadable fundus photographs were available for 2836 (81.8%) individuals. Mean DFD was 4.76 ± 0.34mm (median: 4.74 mm; range: 3.76–6.53mm). In multivariate analysis, longer DFD was associated with longer axial length (P<0.001; standardized correlation coefficient beta: 0.62), higher prevalence of axially high myopia (P<0.001; beta:0.06), shallower anterior chamber depth (P<0.001; beta:-0.18), thinner lens thickness (P = 0.004; beta: -0.06), smaller optic disc-fovea angle (P = 0.02; beta: -0.04), larger parapapillary alpha zone (P = 0.008; beta: 0.05), larger parapapillary beta/gamma zone (P<0.001; beta: 0.11), larger optic disc area (P<0.001; beta: 0.08), lower degree of cortical cataract (P = 0.002; beta: -0.08), and lower prevalence of age-related macular degeneration (P = 0.001; beta: -0.06). Bruch´s membrane opening-fovea distance (DFD minus disc radius minus parapapillary beta/gamma zone width) in non-glaucomatous eyes was not significantly (P = 0.60) related with axial length in emmetropic or axially myopic eyes (axial length ≥23.5 mm), while it increased significantly (P<0.001; r: 0.32) with longer axial length in eyes with an axial length of <23.5mm. Ratio of mean DFD to disc diameter was 2.65 ± 0.30. If the ratio of disc-fovea distance to disc diameter was considered constant and if the individual disc diameter was calculated as the individual disc-fovea distance divided by the constant factor of 2.65, the resulting calculated disc diameter differed from the directly measured disc diameter by 0.16 ±0.13 mm (median: 0.13 mm, range: 0.00–0.89 mm) or 8.9 ± 7.3% (median: 7.4%; range: 0.00–70%) of the measured disc diameter.ConclusionsDFD (mean: 4.76mm) increases with longer axial length, larger parapapillary alpha zone and parapapillary beta/gamma zone, and larger disc area. The axial elongation associated increase in DFD was due to an enlargement of parapapillary beta/gamma zone while the Bruch’s membrane opening-fovea distance did not enlarge with longer axial length. This finding may be of interest for the process of emmetropization and myopization. Due to its variability, the disc-fovea distance has only limited clinical value as a relative size unit for structures at the posterior pole.

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“…Spectral domain optical coherence tomography (SD-OCT, Spectralis ® , Heidelberg Engineering Co., Heidelberg, Germany), also with the enhanced depth imaging modality, was performed after pupil dilation to measure the thickness of the RNFL and of the subfoveal choroid [ 28 ]. The degree of cataract was determined using the standardized lens photographs as described recently [ 29 ]. Diabetic retinopathy was diagnosed on the fundus photographs [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Optic Disc - Fovea Angle: The Beijing Eye Study 2011

et al. 2015

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PurposeTo determine the optic disc-fovea angle (defined as angle between the horizontal and the line between the optic disc center and the fovea) and to assess its relationships with ocular and systemic parameters.MethodsThe population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals. A detailed ophthalmic examination was carried out. Using fundus photographs, we measured the disc-fovea angle.ResultsReadable fundus photographs were available for 6043 eyes of 3052 (88.0%) individuals with a mean age of 63.6±9.3 years (range: 50–91 years) and a mean axial length of 23.2±1.0 mm (range: 18.96–28.87 mm). Mean disc-fovea angle was 7.76 ± 3.63° (median: 7.65°; range: -6.3° to 28.9°). The mean inter-eye difference was 4.01 ± 2.94° (median: 3.49°; range: 0.00–22.3°). In multivariate analysis, larger disc-fovea angle was associated (regression coefficient r2: 0.08) with older age (P = 0.009; standardized regression coefficient beta: 0.05), thinner RNFL in the nasal superior sector (P<0.001; beta: -0.17), superior sector (P<0.001; beta: -0.10) and temporal superior sector (P<0.001; beta: -0.11) and thicker RNFL in the inferior sector (P<001; beta: 0.13), nasal inferior sector (P<001; beta: 0.13) and nasal sector (P = 0.007; beta: 0.06), higher prevalence of retinal vein occlusion (P = 0.02; beta: 0.04), and with larger cylindrical refractive error (P = 0.04; beta: 0.04).ConclusionsThe optic disc-fovea angle markedly influences the regional distribution of the RNFL thickness pattern. The disc-fovea angle may routinely be taken into account in the morphological glaucoma diagnosis and in the assessment of structure-function relationship in optic nerve diseases. Future studies may address potential associations between a larger disc-fovea angle and retinal vein occlusions and between the disc-fovea angle and the neuroretinal rim shape.

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Subfoveal Choroidal Thickness and Cataract: The Beijing Eye Study 2011

Abstract: Although nuclear cataract was not significantly associated with an abnormal SFCT, the association between thin SFCT and subcapsular cataract or cortical cataract may have clinical importance, because thin SFCT is associated with low vision.

Cited by 8 publications

References 26 publications

The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy

The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

Optic Disc - Fovea Angle: The Beijing Eye Study 2011

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