Subepithelial collagen in intestinal malabsorption.

Bossart, Rita; Henry, Kristin; Booth, C. C.; Doe, William F.

doi:10.1136/gut.16.1.18

Cited by 60 publications

(30 citation statements)

References 6 publications

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“…2,11 This view has been challenged by a few. 4,8 However, the clinical and pathological manifestations of this disorder have not been investigated adequately, as data regarding its prevalence and etiology are limited and definitional criteria are suboptimal. Our study represents the first large comprehensive single institution study describing the histopathological and phenotypical features, clinical characteristics, therapeutic strategies, and outcomes of individuals with a thickened small bowel subepithelial collagen table.…”

Section: Discussionmentioning

confidence: 99%

“…Qualitative descriptions of increased subepithelial fibrosis have been reported in 36-42% of small bowel biopsies from celiac disease patients, 4,28 which have been interpreted as common and nonspecific findings lacking any clinical significance. 4 It has been argued that a diagnosis of collagenous sprue requires the presence of 'a clear-cut layer of subepithelial collagen that extends into the lamina propria.'…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16] The occurrence of collagenous sprue has been reported in individuals with celiac disease, tropical sprue, milk intolerance, myotonic dystrophy, malignancy-related paraneoplastic syndrome, and common variable immunodeficiency. 4,5,10,11,14,17,18 These studies have suggested that subepithelial collagen deposition might be a non-specific feature.…”

mentioning

confidence: 99%

“…Regardless of the etiology, collagenous sprue is thought to portend a poor prognosis with severe morbidity and mortality 2,4,6,11,13 and has been described as a manifestation of refractory sprue. 5,11 A few studies, however, have reported a good response to treatment and favorable outcomes.…”

mentioning

confidence: 99%

“…5,11 A few studies, however, have reported a good response to treatment and favorable outcomes. 4,[8][9][10] The discrepant findings have been attributed to inclusion of cases with mild alterations of the subepithelial collagen table in some studies, but currently there are no well-defined histological criteria for diagnosing collagenous sprue.…”

mentioning

confidence: 99%

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Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients

et al. 2010

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Collagenous sprue is associated with high morbidity; however, the etiology of this disorder is unclear. Data regarding the pathological and clinical manifestations of patients with collagenous sprue are also limited. We, thus, undertook this study to gain insight into the etiology, disease manifestations and outcomes of collagenous sprue. We searched our departmental database (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) to identify cases of collagenous sprue and to obtain clinical and laboratory data. Small bowel histology, including thickness of subepithelial collagen, intra-epithelial lymphocyte phenotype and results of T-cell clonality assays were evaluated. Nineteen patients (15 women, 4 men, age 22-80 years, mean 57 years) were identified.

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