Subepithelial Changes in Oral Submucous Fibrosis

Sirsat, Satyavati M.; Pindborg, J. J.

doi:10.1111/j.1699-0463.1967.tb01278.x

Cited by 63 publications

(27 citation statements)

References 12 publications

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“…Sirsat and Pindborg [11] found a wide age range in patients of OSF, although majority were between 30 and 50 years age group. Pindborg (1965) in a comparative study of Bombay and Lucknow reported that youngest patient was 32 and oldest was 72 years of age [4].…”

Section: Incidence Of Various Pre-cancerous Lesions Of the Oral Cavitymentioning

confidence: 95%

“…Pindborg and Sirsat [11] observed that at the onset of disease, initial symptom was burning in the mouth but later there was stiffening of oral mucosa leading to difficulty in mouth opening. The cases with leukoplakia presented with a painless white plaque in oral cavity, whereas cases with erythroplakia presented with a red macule in the oral cavity.…”

Section: Presenting Complaintsmentioning

confidence: 99%

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Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

Shukla¹

2013

Indian J Otolaryngol Head Neck Surg

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Oral cancers in India, unlike in the West are the most common cancers encountered, be it a primary or a tertiary referral practice. This makes the study and management of these cancers an important issue especially for the otolaryngologist. It is well known that the most common variant of oral cancers is the squamous cell carcinoma. Also the etiology is well established; with tobacco use in both smoking and smokeless forms, alcohol, betel nut and recently the Human Papilloma virus infection being implicated. Certain conditions which definitely increase the probability of getting oral cancers are known and this study aims in revisiting these aspects of premalignancy. The progression from a pre-cancerous lesion/ condition to frank cancer is well established across many studies and many specialties. Also timely recognizing these pre-cancerous conditions and administration of proper treatment will greatly help in reducing the morbidity and mortality from subsequent much advanced and dangerous oral cancer. Keeping these facts in mind this study was planned to study the established pre-cancerous lesions which are known to progress to oral cancers.

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Section: Incidence Of Various Pre-cancerous Lesions Of the Oral Cavitymentioning

confidence: 95%

Section: Presenting Complaintsmentioning

confidence: 99%

Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

Shukla¹

2013

Indian J Otolaryngol Head Neck Surg

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“…Blanching, i.e., marble-like appearance of the oral mucosa and stiffness of the oral mucosa. [51] 2. Trismus (reduced mouth opening).…”

Section: Etiopathogenesismentioning

confidence: 99%

“…[49] [50] Clinical Features & Stages: Early OSMF includes a burning sensation in the mouth when consuming spicy food, appearance of blisters especially on the palate, ulcerations or recurrent generalized inflammation of the oral mucosa. [51] The most common initial symptoms of submucous fibrosis are burning sensation of the oral mucosa aggravated by spicy food (42%), followed by either hyper salivation or dryness of the mouth (25%). [52] :…”

Section: Etiopathogenesismentioning

confidence: 99%

Recent Concepts of Etiopathogenesis and Management of Oral Submucous Fibrosis: A Review of Literature

Singh¹

2015

jemds

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Oral submucous fibrosis (OSF) is a well-recognized chronic insidious disease, precancerous condition, autoimmune and collagen related disorder which is multifactorial in origin mainly associated with the practice of chewing betel quid containing areca nut, a habit common among lower socio-economic strata of society. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit mouth opening. In the myriad of literature available, numerous etiology and management techniques are put forward by various authors in the past. In this paper, an attempt is made to analyze critically and update the knowledge of the recent developments that enhances the understanding of the etiology of this premalignant condition and its medicinal & surgical management which improves the life expectancy.

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“…5 Occasionally it is preceded by and/or associated with vesicle formation and is always associated with juxta-epithelial inflammatory reaction followed by progressive hyalinization of lamina propria. 6,7 The later subendothelial and submucosal myofibrosis leads to stiffness of the oral mucosa and deeper tissues with progressive limitation in the opening of the mouth and prostrusion of the tongue, thus causing difficulty in eating, swallowing and phonation. 8 There may be marked epithelial atropy.…”

Section: Introductionmentioning

confidence: 99%

Level of serum lactate dehydrogenase in oral submucous fibrosis

Swamy

Ganiger

2016

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cancer is one of the most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Of all oral premalignant conditions, oral submucous fibrosis (OSMF) is of greater concern because of its disabling nature and relative greater chances of malignant transformation. Transformation of normal tissue to premalignant lesion and further to oral cancer results in alteration in glycolytic pathway and hence the lactate dehydrogenase (LDH) levels. The aim of this study was to estimate the LDH levels in serum of subjects with OSMF and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF and the LDH enzyme.Methods: It is a case control study. The study included 40 diagnosed cases of OSMF and 40 matched healthy controls. Venous blood of 3 ml was collected in both cases and controls. Serum was separated by centrifugation and LDH was estimated by using standard kits. Statistical analysis was done using student ‘t’ test. Pearson's correlation was performed to establish the relationship between study variables. Results: It was observed that serum LDH levels were significantly increased in cases of OSMF as compared to controls (p <0.005).Conclusions: Serum LDH was significantly increased in OSMF and can be used as a valuable biochemical marker in prognosis of OSMF.

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Subepithelial Changes in Oral Submucous Fibrosis

Cited by 63 publications

References 12 publications

Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

Recent Concepts of Etiopathogenesis and Management of Oral Submucous Fibrosis: A Review of Literature

Level of serum lactate dehydrogenase in oral submucous fibrosis

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