Subependymal giant cell astrocytoma with high choline/creatine ratio on proton MR spectroscopy

Neto, Arnolfo de Carvalho; Gasparetto, Emerson L.; Bruck, Isac

doi:10.1590/s0004-282x2006000500033

Cited by 16 publications

(8 citation statements)

References 8 publications

(19 reference statements)

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“…Several studies have proposed that these tumors could arise from subependymal nodules 10,11 . In a previous report, the 1H-MRS of a proven SGCA showed high choline (Cho/Cr) (1.60) and low NAA/Cr (0.93) ratios, similar to other brain neoplasms 12 . The authors suggested the 1H-MRS might be a valuable tool for early detection of neoplastic transformation in subependymal nodules arising near to the foramen of Monro in TSC patients.…”

supporting

confidence: 57%

“…Tarasów et al 19 found reduced NAA/Cr and slight increased Cho/Cr ratios, but the exact location of the nodule was not mentioned. A recent study reported a case of TSC presenting with a 15 mm nodule at the left foramen of Monro 12 . The lesion had heterogeneous signal on T1 and T2-weighted images, and strong enhancement after contrast administration.…”

Section: Discussionmentioning

confidence: 99%

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Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex

Carvalho-Neto¹,

Bruck²,

Antoniuk³

et al. 2008

Arq. Neuro-Psiquiatr.

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-Purpose:To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC). Method: Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant. Results: There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05). Conclusion: The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.Key woRdS: tuberous sclerosis complex, magnetic resonance imaging, proton spectroscopy. espectroscopia de prótons por rM da região do forame de Monro em pacientes com complexo esclerose tuberosaResumo -Objetivo: Avaliar através de espectroscopia de prótons as relações dos metabólitos da região do forame de Monro em pacientes com complexo esclerose tuberosa (CeT). Método: doze pacientes com CeT e um grupo controle pareado por sexo e idade realizaram RM em aparelho de 1,5T, e a espectroscopia de prótons foi obtida ao nível do forame de Monro com aquisição multi-voxel. Volumes de interesse similares foram posicionados em cada lado do forame de Monro e nos gânglios da base (núcleos lentiformes). os valores das relações e amplitudes de pico do N-acetilaspartato (NAA), creatina (Cr) e colina (Cho) foram estudados. A análise estatística foi realizada e valores de p<0,05 foram considerados estatisticamente significativos. Resultados: Não houve diferença significativa entre as relações NAA/Cr e Cho/Cr na região do forame de Monro e nos gânglios da base dos pacientes com CeT comparados com os controles (p>0,05). Conclusão: As relações NAA/Cr e Cho/Cr na região do forame de Monro e nos gânglios da base de pacientes com CeT são semelhantes àquelas obtidas no grupo controle. PAlAVRAS-CHAVe: complexo esclerose tuberosa, imagem por ressonância magnética, espectroscopia de prótons.

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supporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex

Carvalho-Neto¹,

Bruck²,

Antoniuk³

et al. 2008

Arq. Neuro-Psiquiatr.

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“…When subependymal nodules are located near the foramen of Monro a they measure more than 5 mm in diameter, are not or are incompletely calcified, and are enhanced by gadolinium, repeat MR imaging should be recommended (26). MR spectroscopy of SGCAs shows high Cho/Cr and low NAA/Cr ratios, which may b useful for distinguishing them from subependymal nodules (27). 15%-27% and of cystlike lesions is 15%-44% (11,28,29).…”

Section: Cortical Tubersmentioning

confidence: 99%

Pictorial Review of Tuberous Sclerosis in Various Organs

Umeoka¹,

Koyama²,

Miki³

et al. 2008

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Tuberous sclerosis is a rare autosomal dominant neurocutaneous syndrome characterized by the presence of benign congenital tumors in multiple organs. The diagnosis is usually established on the basis of diagnostic criteria applied to physical or radiologic findings. Because the classical triad of epilepsy, mental retardation, and adenoma sebaceum is uncommonly seen at clinical examination, radiologic examinations can play an important role in the diagnosis of tuberous sclerosis and in treatment. Cardiac rhabdomyoma, renal angiomyolipoma, and neurologic involvement encompassing cortical or subependymal tubers and white matter abnormalities are the common radiologic findings. Detection of these entities can be strong evidence for suspecting tuberous sclerosis. The presence of pulmonary lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, or multiple renal cysts also raises suspicion of tuberous sclerosis. Moreover, tuberous sclerosis can involve bone, liver, and the alimentary tract. The clinical course and patient prognosis depend on the sites of manifestations. Familiarity with the clinical and radiologic findings in various organs is crucial in diagnosis and treatment.

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“…MR spectroscopy may be useful in distinguishing SEGAs with high Cho/Cr and low NAA/Cr ratios from SENs. [31] In the absence of stigmata of TSC, a mass at the foramen of Monro may bring forth a differential diagnosis of choroid plexus papilloma, meningioma or neurocytoma. Choroid plexus papillomas are more common in infants than in adults, where they typically are located in the atrium of the lateral ventricle.…”

Section: Cns Lesionsmentioning

confidence: 99%

Clinically Relevant Imaging in Tuberous Sclerosis

Radhakrishnan

Verma

2011

Journal of Clinical Imaging Science

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Tuberous sclerosis (TS), also known as Bourneville disease or Bourneville–Pringle disease, is an autosomal dominant genetic disorder classically characterized by the presence of hamartomatous growths in multiple organs. TS and tuberous sclerosis complex (TSC) are different terms for the same genetic condition. Both terms describe clinical changes due to mutations involving either of the two genes named TSC1 and TSC2, which regulate cell growth. The diagnosis of TSC is established using diagnostic criteria based on clinical and imaging findings. Routine screening and surveillance of patients with TSC is needed to determine the presence and extent of organ involvement, especially the brain, kidneys, and lungs, and identify the development of associated complications. As the treatment is organ specific, imaging plays a crucial role in the management of patients with TSC.

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Subependymal giant cell astrocytoma with high choline/creatine ratio on proton MR spectroscopy

Cited by 16 publications

References 8 publications

Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex

Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex

Pictorial Review of Tuberous Sclerosis in Various Organs

Clinically Relevant Imaging in Tuberous Sclerosis

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