Subendometrial resistence and pulsatility index assessment of endometrial receptivity in assisted reproductive technology cycles

Abstract

Objective To evaluate Subendometrial and Uterine artery resistance and pulsatility index continuous analysis as a predictor of Endometrial receptivity in Assisted Reproductive Technology (ART) Cycles. Design Serial 2D transvaginal coloured power doppler ultrasound performed in women on ART cycle to evaluate a pattern that better predicts implantation rates. One hundred sixty-nine subjects on a prospective case control study were assessed. Uterine artery and Subendometrial resistance and pulsatility index was performed to all subjects at baseline (prior to ovarian controlled stimulation), at day 6, 8 and 10 of controlled ovarian stimulation, at trigger day and at embryo transfer day. Also the ratio of fluxometric parameters between Subendometrial blood flow and uterine artery was measured. Results No statistical difference was noted between two groups in terms of demographics and ART procedures and scores. Uterine artery resistance and pulsatility index showed statistical difference between the two groups (implantation versus non-implantation group). Also statistical significance was obtained between two groups in terms of Subendometrial vascularization. Ratio between Subendometrial and Uterine artery showed lower values of fluxometric parameters in all range for the Subendometrial territory. Conclusions Serial Subendometrial and Uterine artery fluxometry may be a useful tool for clinicians in predicting endometrial receptivity enhancing elective embryo transfers in the same ART cycle.

Continuous endometrial volumetric analysis for endometrial receptivity assessment on assisted reproductive technology cycles

“…Some published work has recently proven a pattern of hemodynamic changes in utero-ovarian arteries during ART cycles with predictive value on endometrial receptivity [ 10 ]. Hou et al have also confirmed the possibility of non-invasive prediction of success in ART cycles, with serial assessments of the echogenicity pattern transformation, after human recombinant gonadrotropin hormone [ 11 ]. The aim of this prospective study is to further evaluate the capability of serial and continuous evaluation of biophysical markers as a non-invasive procedure to determine endometrial receptivity [ 12 , 13 ].…”

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

“…Endometrial blood perfusion is an important factor for endometrial growth [ 56 ]. Resistance and pulsatility index of subendometrial and uterine artery are useful tools for clinicians in predicting endometrial receptivity [ 57 ]. High blood flow impedance of uterine radial arteries is associated with poor endometrial growth in patients with thin endometrium [ 21 ].…”

Endometrial Receptivity on Assisted Reproductive Technology Cycles – a correlation between Serial Serum Estradiol levels and Serial Endometrial Volume Assessment

“…Recent studies (Silva Martins, R. et al) have proven that perhaps serial evaluations provide better understanding rather than a single scoop at a pre-determined phase of the process. (18)(19) The main purpose of this study was to assess both parameters not only in a single scope pre-determined moment but with a serial prospective continuous evaluation.…”

“…This study integrates part of a major protocol study and methodological used shares similitude to previous published article by Silva Martins, R. (18).…”