Subdural electrodes

Lesser, Ronald P.; Crone, Nathan E.; Webber, W. R.

doi:10.1016/j.clinph.2010.04.037

Cited by 70 publications

(57 citation statements)

References 97 publications

(126 reference statements)

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“…On the other hand, microlocalization is used in the preparation for cortical epilepsy surgery, where subdural electrode grids are placed in order to define a specific site of seizure origin [6]. In addition, personalized medicine is here available via interventions that have been customized to the individual patient's brain.…”

Section: Localization and Microlocalizationmentioning

confidence: 99%

Neocortical Simulation for Epilepsy Surgery Guidance: Localization and Intervention

Lytton

Neymotin

Wester

et al. 2013

Computational Surgery and Dual Training

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New surgical and localization techniques allow for precise and personalized evaluation and treatment of intractable epilepsies. These techniques include the use of subdural and depth electrodes for localization, and the potential use for celltargeted stimulation using optogenetics as part of treatment. Computer modeling of seizures, also individualized to the patient, will be important in order to make full use of the potential of these new techniques. This is because epilepsy is a complex dynamical disease involving multiple scales across both time and space. These complex dynamics make prediction extremely difficult. Cause and effect are not cleanly separable, as multiple embedded causal loops allow for many scales of unintended consequence. We demonstrate here a small model of sensory neocortex which can be used to look at the effects of microablations or microstimulation. We show that ablations in this network can either prevent spread or prevent occurrence of the seizure. In this example, focal electrical stimulation was not able to terminate a seizure but selective stimulation of inhibitory cells, a future possibility through use of optogenetics, was efficacious.

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Section: Localization and Microlocalizationmentioning

confidence: 99%

Neocortical Simulation for Epilepsy Surgery Guidance: Localization and Intervention

Lytton

Neymotin

Wester

et al. 2013

Computational Surgery and Dual Training

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“…Just as there are variations in the functional responses to stimulation, there are variations in the occurrences of ADs. Just as functional localizations can vary, stimulation at the same intensity does not necessarily produce ADs with repeated stimulation, and the sites to which ADs spread can vary from one stimulation event to the next [13,14]. …”

Section: Clinicalmentioning

confidence: 99%

“…The likelihood of terminating ADs is better if stimulation begins at the negative peak of the AD waveform [16]. Beyond this, there are no specific stimulation parameters that have been shown to consistently improve the likelihood of terminating ADs [14]. If we understand more about the basic physiology, biochemistry, and microanatomy underlying the responses to stimulation, we will be more likely to improve the efficacy of stimulation for treating seizures.…”

Section: Clinicalmentioning

confidence: 99%

Proceedings of the Fifth International Workshop on Advances in Electrocorticography

Ritaccio

Brunner

Gündüz

et al. 2014

Epilepsy & Behavior

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The Fifth International Workshop on Advances in Electrocorticography convened in San Diego, CA, on November 7–8, 2013. In the interval year since the last workshop, advancements in methodology, implementation, and commercialization across both research and clinical interests were the focus of the gathering. Electrocorticography (ECoG) is now firmly established as a preferred signal source for advanced research in functional, cognitive, and neuroprosthetic domains. Published output in ECoG fields has increased tenfold in the past decade. This proceedings attempts to summarize the state of the art.

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“…They can be used for presurgical epilepsy monitoring, as aid for tumor resections or for providing brain-computer interfaces [1]. A manufacturing technology for electrodes with a high spatial resolution based on laser structuring was first described by Schuettler et al in 2005, using exclusively medical grade silicone rubber (PDMS) as insulation material and metal foil as electrode material [2].…”

Section: Introductionmentioning

confidence: 99%

Mechanical characterization of neural electrodes based on PDMS-parylene C-PDMS sandwiched system

Henle

Hassler

Köhler

et al. 2011

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Manufacturing of neural electrodes based on metal foil and silicone rubber using a laser is a simple and promising method. A handicap of such electrode arrays is the mechanical robustness of the thin metal tracks that connect the electrode sites with the interconnection pads. Embedding of structured parylene C foil in silicone rubber turned out to be an interesting method to increase the robustness. Test samples with 12.5 μm thick platinum tracks and a 15 μm thick embedded and RIE-structured parylene C foil showed more than 800 % higher ultimate strength until breakage of the tracks. Different structured parylene C foil showed increasing robustness with increasing hole-spacing.

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Subdural electrodes

Abstract: Subdural electrodes are frequently used to aid in the neurophysiological assessment of patients with intractable seizures. We review the indications for these, their uses for localizing epileptogenic regions and for localizing cortical regions supporting movement, sensation, and language.

Cited by 70 publications

References 97 publications

Neocortical Simulation for Epilepsy Surgery Guidance: Localization and Intervention

Neocortical Simulation for Epilepsy Surgery Guidance: Localization and Intervention

Proceedings of the Fifth International Workshop on Advances in Electrocorticography

Mechanical characterization of neural electrodes based on PDMS-parylene C-PDMS sandwiched system

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