Subdivisions of idiopathic autoimmune chronic active hepatitis

Maddrey, Willis C.

doi:10.1002/hep.1840070631

Cited by 50 publications

(17 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CAH is a clinically and morphologically defined syndrome arising from a variety of differ-A preliminary report on this work was presented at the Annual Meeting of the American Gastroenterological Association, 14-18 May 1988, New Orleans, LA. ent etiologies (1,2). In addition to hepatitis B virus (HBV) induced CAH, HBV negative CAH consists of a diverse group of diseases, including non-A, non-B viral CAH, and idiopathic autoimmune type CAH.…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of circulating autoantibodies has defined three subgroups of idiopathic autoimmune type CAH (1-3). LKM-1 autoantibodies characterize one subgroup of idiopathic autoimmune CAH (1)(2)(3)(4)(5)(6)(7). LKM-l antibodies are not associated with either classical autoimmune CAH, which is positive for antinuclear antibody (1,7,8) or with the third subgroup, characterized by autoantibodies against a soluble liver antigen (SLA) (1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

Manns¹,

Johnson²,

Griffin³

et al. 1989

J. Clin. Invest.

355

152

View full text Add to dashboard Cite

Type 1, liver kidney microsomal autoantibodies (LKM-1) are associated with a subgroup of idiopathic autoimmune type, chronic active hepatitis (CAH). The antigenic specificity of LKM-1 autoantibodies from 13 patients was investigated by immunoblot analysis of human liver microsomal proteins. Polypeptides of 50, 55, and 64 kD were detected with these antisera. A high titer LKM-1 serum was selected to screen a human liver XgtlI cDNA expression library, resulting in the isolation of several complementary (c)DNA clones. Autoantibodies affinity purified from proteins expressed by two of the immunopositive cDNA clones, HLD8.2 and HLD13.2, specifically react with a 50-kD protein of human liver microsomes and display immunofluorescence staining of the proximal renal tubular epithelia characteristic of LKM-1 sera.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

Manns¹,

Johnson²,

Griffin³

et al. 1989

J. Clin. Invest.

355

152

View full text Add to dashboard Cite

show abstract

“…Os principais achados laboratoriais ao diagnóstico de HAI foram: elevação da ALT (média 377 U/L; DP 351) e AST (média 523 U/L; DP 485); e hipergamaglobulinemia (média 3 g/dl; DP 1,25 Na análise histopatológica, as principais alterações foram necrose em saca-bocados (93,7%), inflamação portal moderada a acentuada (78,1%), cirrose definitiva e/ou incompleta (76,9%), ausência de lesões dos ductos biliares (93,7%) e presença de rosetas (90,6%) (Tabela 2). A avaliação da graduação histopatológica hepática foi possí-vel em trinta e dois dos trinta e nove pacientes com diagnós-tico de HAI, em decorrência do material obtido bastante fragmentado, com número reduzido de espaços porta.…”

Section: Resultsunclassified

“…A hepatite auto-imune (HAI) é uma forma de hepatite crônica que acomete um grupo de pacientes que perderam a tolerância imunológica a antígenos do próprio fígado [1][2][3][4][5][6] . O diagnóstico é baseado na presença de achados clínicos, laboratoriais e exclusão de outras causas de doença hepáti-ca crônica.…”

Section: Introductionunclassified

Hepatite auto-imune em crianças e adolescentes: estudo clínico, diagnóstico e resposta terapêutica

Ferreira¹,

Roquete²,

Penna³

et al. 2002

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

ResumoObjetivo: avaliar o quadro clínico, laboratorial, histopatológico e a resposta ao tratamento imunossupressor em crianças e adolescentes com hepatite auto-imune.Métodos: estudo descritivo de trinta e nove crianças e adolescentes, atendidos no setor de gastroenterologia pediátrica do Hospital das Clínicas da UFMG, no período de 1986 a 1998.Resultados: a idade variou de 1,6 a 17 anos (média 8,7±3,49), com predomínio do sexo feminino (87,2%). Ocorreram três formas de apresentação clínica: crônica (53,9%), aguda (41%) e falência hepática grave (5,1%). A alteração laboratorial mais relevante foi a elevação das aminotransferases e gama-globulina. O fator antinuclear foi positivo em 66,7% dos pacientes, antimúsculo liso em 52,8%, e o antimicrossomal de fígado e rim em 3%. Na histopatologia, destacaram-se a necrose em saca-bocados (93,7%), inflamação portal moderada a acentuada (78,1%), cirrose definitiva e/ou incompleta (76,9%), ausência de lesões dos ductos biliares (93,7%) e presença de rosetas (90,6%). No tratamento, 77,8% obtiveram resposta completa, com efeitos colaterais em 27,8% dos pacientes. Ocorreram sete (17,9%) óbitos. No decurso do tratamento, ocorreu redução com significância estatítica do escore z para estatura/idade.Conclusões: a hepatite auto-imune predomina no sexo feminino, com formas de apresentação clínica variada, presença de autoanticorpos, elevação das aminotransferases e hipergamaglobulinemia. Predomínio histopatológico de cirrose incipiente e/ou definitiva, com inflamação portal de moderada a acentuada e necrose em saca-bocados. O tratamento com corticosteróide e azatioprina em doses diárias revelou-se efetivo, todavia, a diminuição do escore z para estatura/idade representa, provavelmente, um efeito indesejá-vel do corticóide.J Pediatr (Rio J) 2002; 78 (4): 309-14: hepatite auto-imune, criança, adolescente, diagnóstico, tratamento. AbstractObjective: the aim of this study was to evaluate the clinical, laboratory and histopathological characteristics and the response to immunosuppression in children and adolescents with autoimmune hepatitis (AIH).Methods: the present research is a descriptive study consisting of 39 children and adolescents with AIH who receive care at the Department of Pediatric Gastroenterology of Hospital das Clínicas (UFMG) from 1986 to 1998.Results: children's age ranged from 1.6 to 17 years (mean 8.7 ± 3.49), most of them were females (87.2%). There were three types of clinical presentations: chronic (53.9%), acute (41%), and serious hepatic failure (5.1%). The most relevant laboratory parameters were the aminotransferases and g-globulin increase. Antinuclear antibodies were positive in 66.7% of the patients, while smooth muscle antibodies were positive in 52.8% and anti-LKM1 in 3% of the patients. In the histopathology the most important findings were the piecemeal necrosis (93.7%), moderate to severe portal inflammation (78.1%), definitive or incomplete cirrhosis (76.9%), absence of lesion of biliary ducts (93.7%) and presence of rosettes (90.6%). During the treatm...

show abstract

“…Autoimmune hapatitis is subclassified according to immunoserological markers into three types; type 1, type 2, and type 3 (48). Among these subtypes type 2 autoimmune hepatitis which afflicts mainly children (ages 2 -14 years) is characterized by the presence of anti-LKM 1 (liver/kidney microsome type 1) autoantibodies and more commonly is associated with concurrent extrahepatic immunological diseases such as vitiligo, autoimmune thyroididtis, and type 1 diabetes mellitus (49).…”

Section: 5autoimmune Hepatitismentioning

confidence: 99%

High-throughput radioassays for autoantibodies to recombinant autoantigens

Eisenbarth¹

2000

Front Biosci

View full text Add to dashboard Cite

Subdivisions of idiopathic autoimmune chronic active hepatitis

Cited by 50 publications

References 46 publications

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

Hepatite auto-imune em crianças e adolescentes: estudo clínico, diagnóstico e resposta terapêutica

High-throughput radioassays for autoantibodies to recombinant autoantigens

Contact Info

Product

Resources

About