Subcuticular Sutures and the Rate of Inflammation in Noncontaminated Wounds

Austin, Paul E; Dunn, Kathleen; Eily-Cofield, Kiara; Brown, Charles K.; Wooden, William A.; Bradfield, John F.

doi:10.1016/s0196-0644(95)70289-x

Cited by 35 publications

(27 citation statements)

References 4 publications

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“…A wide variety of evaluation methods have been described 13,[18][19][20][21][22][23][24] as objective means of histologic assessment of wound healing; yet, no single method is universally accepted. In our study, we attempted to eliminate individual bias by creating a histologic scoring system modeled after that first reported by Sewell et al 12 in 1955.…”

Section: Discussionmentioning

confidence: 99%

Comparison of gross and histologic tissue responses of skin incisions closed by use of absorbable subcuticular staples, cutaneous metal staples, and polyglactin 910 suture in pigs

Fick¹,

Novo²,

Kirchhof³

2005

ajvr

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Section: Discussionmentioning

confidence: 99%

Comparison of gross and histologic tissue responses of skin incisions closed by use of absorbable subcuticular staples, cutaneous metal staples, and polyglactin 910 suture in pigs

Fick¹,

Novo²,

Kirchhof³

2005

ajvr

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“…Biodegradable and biocompatible polymers, such as poly(lactide‐ co ‐glycolide) (PLGA), have gained much attention and research focus for use in the controlled release of therapeutic proteins. PLGA has been used for many years in various medical applications (i.e., surgical sutures) and the safety of the polymer is well‐established 2–4. A variety of delivery systems, such as microspheres and millicylindrical implants, can be produced using PLGA, and specific release profiles may be generated through manipulating the properties of the polymer 5.…”

Section: Introductionmentioning

confidence: 99%

BSA Degradation Under Acidic Conditions: A Model For Protein Instability During Release From PLGA Delivery Systems

Estey

Kang

Schwendeman

et al. 2006

Journal of Pharmaceutical Sciences

192

129

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Acidification of the internal poly(lactide-co-glycolide) (PLGA) microenvironment is considered one of the major protein stresses during controlled release from such delivery systems. A model protein, bovine serum albumin (BSA), was incubated at 37 degrees C for 28 days to simulate the environment within the aqueous pores of PLGA during the release phase and to determine how acidic microclimate conditions affect BSA stability. Size-exclusion high performance liquid chromatography (SE-HPLC), SDS-PAGE, and infrared spectroscopy were used to monitor BSA degradation. BSA was most stable at pH 7, but rapidly degraded via aggregation and hydrolysis at pH 2. These simulated degradation products were nearly identical to that of unreleased BSA found entrapped within PLGA 50/50 millicylinders. At pH 2, changes in BSA conformation detected by various spectroscopic techniques were consistent with acid denaturation of the protein. By contrast, at pH 5 and above, damage to BSA was insufficient to explain the instability of the protein in the polymer. Thus, these data confirm the hypothesis that acid-induced unfolding is the basis of BSA aggregation in PLGA and the acidic microclimate within PLGA is indeed a dominant stress for encapsulated BSA. To increase the stability of proteins within PLGA systems, formulations must protect against potentially extreme acidification such that native structure is maintained.

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“…Safe use of this copolymer in suture material and bone fixation devices has been previously described in children (6,7), and similar microsphere systems are currently used in other commercially available sustained release products (8). After sc administration, GH is released from these microspheres in a biphasic manner.…”

Section: He Introduction Of Recombinant Human Ghmentioning

confidence: 99%

A Multicenter Study of the Efficacy and Safety of Sustained Release GH in the Treatment of Naive Pediatric Patients with GH Deficiency

Reiter¹,

Attie²,

Moshang³

et al. 2001

The Journal of Clinical Endocrinology & Metabolism

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Treatment of naive children with GH deficiency has relied upon long-term replacement therapy with daily injections of GH. The daily schedule may be inconvenient for patients and their caregivers, possibly promoting nonadherence with the treatment regimen or premature termination of treatment. We studied a new sustained release GH formulation, administered once or twice monthly, to determine its efficacy and safety in this population.Seventy-four prepubertal patients with documented GH deficiency were randomized to receive sustained release recombinant human GH at either 1.5 mg/kg once monthly or 0.75 mg/kg twice monthly by sc injection in a 6-month open-label study. Efficacy was determined by growth data from 69 patients completing 6 months and 56 patients completing 12 months in an extension study.Growth rates were significantly increased over baseline and were similar for the two dosage groups. The mean (؎SD) annualized growth rate (pooled data) was 8.4 ؎ 2.1 cm/yr at 6 months, and the growth rate was 7.8 ؎ 1.8 at 12 months compared with 4.5 ؎ 2.3 at baseline. Standardized height, bone age, and predicted adult height assessments demonstrated catch-up growth without excessive skeletal maturation. Injection site-related events (including pain, erythema, and nodules) were the most commonly reported adverse events; no serious adverse events related to treatment were reported.

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Subcuticular Sutures and the Rate of Inflammation in Noncontaminated Wounds

Cited by 35 publications

References 4 publications

Comparison of gross and histologic tissue responses of skin incisions closed by use of absorbable subcuticular staples, cutaneous metal staples, and polyglactin 910 suture in pigs

Comparison of gross and histologic tissue responses of skin incisions closed by use of absorbable subcuticular staples, cutaneous metal staples, and polyglactin 910 suture in pigs

BSA Degradation Under Acidic Conditions: A Model For Protein Instability During Release From PLGA Delivery Systems

A Multicenter Study of the Efficacy and Safety of Sustained Release GH in the Treatment of Naive Pediatric Patients with GH Deficiency

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