Subcutaneous tranexamic acid in upper eyelid blepharoplasty: a prospective randomized pilot study

Sagiv, Oded; Rosenfeld, Elkanah; Kalderon, Elinor; Barazani, Tamar Brutman; Zloto, Ofira; Martinowitz, Uriel; Simon, Guy J. Ben; Zilinsky, Isaac

doi:10.1016/j.jcjo.2018.01.006

Cited by 32 publications

(48 citation statements)

References 19 publications

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“…In our current review, fourteen articles assessed the topical/ local use of TXA; this is a significant increase since the last systematic review on this topic [28]. This study also highlights more novel approaches of using TXA, in tumescent fluid for liposuction and blepharoplasty procedures [50,53,54].…”

Section: Discussionmentioning

confidence: 89%

“…Sagiv O et al assessed the benefit of locally injecting TXA in an upper eyelid skin-only blepharoplasty. Notably, there was no significant difference between TXA and control groups regarding total surgery time, cumulative cautery time, net blood weight in surgical pads, patient-reported pain level, surgeon's assessment of hemostasis, or periocular ecchymosis size on the first postoperative day [50]. Meanwhile, Schroeder RJ et al (topical and local TXA) and Zilinsky I et al (local TXA) reported beneficial effect of mixing TXA with local anesthetic solution, resulting in decreased drain output and better subjective assessment of hemostasis, respectively [59,62].…”

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 87%

“…Tranexamic acid is the most popular anti-fibrinolytic used in aesthetic surgery [48]. In our review, 23 studies assessed the use of TXA in various aesthetic or breast-related procedures [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64]. [57,59,60], and one was a case series [52].…”

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 99%

“…For topical/local administration, four studies reported topical administration either using soaked pledgets (undefined dosage) [52], soaked sponge tampons (undefined dosage) [57], or wound moistening with a 25 mg/ml TXA-saline solution [49,58]. In addition, three studies reported adding TXA to tumescent solution or local anesthetic solution [50,59,62].…”

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 99%

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Tranexamic acid in plastic surgery: routes of administration and dosage considerations

et al. 2021

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Background Excessive blood loss, during or after surgery, remains a major surgical concern despite the continuous improvement of surgical standards. Tranexamic acid (TXA), an anti-fibrinolytic, is a potential agent that has been used in a variety of methods to mitigate blood loss. In addition, TXA shows additional anti-inflammatory effects which may be of particular interest. The objective of this study is to review clinical studies involving the use of TXA in plastic surgery related procedures. Methods We carried out a literature search of Google Scholar, PubMed, Ovid Medline, and Cochrane databases since their inception for relevant clinical studies on TXA use (dosages/routes of administration) in plastic surgery-related procedures. Results Forty-five articles were included in this review. These included studies assessing the use of TXA in craniofacial surgery (15 studies), aesthetic and breast-related surgeries (23 studies), burn care (4 studies), and microsurgery (3 studies). For each subset, study design, study sample size, surgical procedure performed, TXA route of administration, dosage, study outcomes, and adverse events were summarized and reported in a separate section. Conclusions TXA is widely studied in the field of craniofacial surgery, specifically craniosynostosis surgery. Intravenous administration of TXA is the most commonly studied route of administration. Topical formulations seem to be on the rise and the added local anti-inflammatory effects and safety profile of topical use add significant appeal. Moreover, evidence on appropriate dosage protocols is scarce. The variable approach in dosing warrants further trials to assess the clinical implications, as well as potential benefit in using TXA more efficiently in the field of plastic surgery, as a whole. Level of evidence: Not ratable

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Section: Discussionmentioning

confidence: 89%

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 87%

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 99%

Section: Aesthetic Surgery/breast Surgerymentioning

confidence: 99%

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Tranexamic acid in plastic surgery: routes of administration and dosage considerations

et al. 2021

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“…Three published surgical trials report the bolus administration of TA subcutaneously during surgery [6][7][8]. A total of 188 participants received a single dose of placebo or TA, mixed with lidocaine intraoperatively during skin cancer surgery, facelift and blephoroplasty.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Tranexamic Acid: A Novel Approach to Managing Bleeding

Sutherland¹,

Carey²,

Miller³

2021

annhematoloncol

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We describe the case of a 68 year old with a transglottic squamous cell carcinoma, a tracheostomy and persistent blood stained tracheal secretions. Oral and intravenous Tranexamic Acid (TA) effectively controlled the bleeding. On losing both routes, we administered 2g of TA (20ml) by continuous subcutaneous infusion over 24 hours. Control of bleeding was maintained over 18 days until death. No site reactions were observed. A literature review was undertaken, however, none of the studies looked at the use of TA in an end of life or palliative care population. We identified 3 clinical palliative care guidelines relating to continuous subcutaneous administration of TA. Further use should be reported in the literature to build the evidence base surrounding this novel practice.

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Lower Eyelid Considerations in Lower Facelift

Reed,

Nakra

2023

Plastic Surgery of the Lower Eyelids

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Subcutaneous tranexamic acid in upper eyelid blepharoplasty: a prospective randomized pilot study

Cited by 32 publications

References 19 publications

Tranexamic acid in plastic surgery: routes of administration and dosage considerations

Tranexamic acid in plastic surgery: routes of administration and dosage considerations

Subcutaneous Tranexamic Acid: A Novel Approach to Managing Bleeding

Lower Eyelid Considerations in Lower Facelift

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