Subcutaneous teicoplanin in staphylococcal bone and joint infections

Destrem, A.; Valour, Florent; Ronde-Ousteau, Cécile; Gaudias, J.; Ferry, Tristan; Forestier, E.

doi:10.1016/j.medmal.2019.10.002

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…25 The third study, mainly composed of older patients with BJI, showed that 85% of participants achieved the target C min irrespective of the route of administration (IM, IV, or SC). 64 In addition, Cazaubon et al showed that SC administration of teicoplanin was associated with a lower C min and plasma concentration (AUC) after a 2-day loading phase, but these differences were absent after 14 days because of its drug accumulation. 43,44 SC teicoplanin has also been used to treat infective endocarditis; however, this has only been anecdotal.…”

Section: Teicoplaninmentioning

confidence: 99%

Subcutaneous Antibiotic Therapy: The Why, How, Which Drugs and When

Hernandez-Ruiz

Forestier

Gavazzi

et al. 2021

Journal of the American Medical Directors Association

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Objectives: To describe the rationale for subcutaneous (SC) administration of antibiotics from available published data and to make propositions to help clinicians in daily practice. Design: Narrative review. Setting and Participants: Hospitalized patients, persons in long-term care facilities and ambulatory care. Methods: We searched the MEDLINE/PubMed electronic database for evidence supporting SC administration of antibiotics up to September 2019; the results of this primary search were supplemented by searching the references of the identified articles, as well as by searching in Google Scholar. Results: Regarding tolerability, efficacy, and pharmacokinetic/pharmacodynamic profiles, most studies suggest that the SC route could be an alternative to the intravenous route, particularly for timedependent antibiotics and among certain patient populations, such as patients with poor venous access, swallowing disorders, or behavioral disturbance. However, clinical evidence of the benefits and risks of SC antibiotic administration is still scarce and of low level. Conclusions and Implications: SC administration of antibiotics may be useful in various settings such as in hospitalized patients and among those in long-term care facilities or being cared for at home. However, further clinical studies are needed to assess the pharmacokinetic/pharmacodynamic properties, as well as the risks and benefits of SC administration of antibiotics. In this review, we highlight the potential benefits of SC administration of antibiotics and address practical recommendations for its use. This information will enable improvement of treatment strategies and present the SC route as a potential option in specific situations.

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Section: Teicoplaninmentioning

confidence: 99%

Subcutaneous Antibiotic Therapy: The Why, How, Which Drugs and When

Hernandez-Ruiz

Forestier

Gavazzi

et al. 2021

Journal of the American Medical Directors Association

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“…Five studies reported SC teicoplanin PK data in patients (∼80 patients) with suspected or confirmed nosocomial infections admitted to ICU, geriatric, or ID departments (37)(38)(39)(40)(41). AUC and Cmin were lower when teicoplanin was administrated with SC compared with IV during the loading phase; however, these differences disappeared overtime, indicating that IV route should be preferred during the first days of treatment and SC could be used afterwards with adequate Cmin and AUC/MIC (40).…”

Section: Main Pharmacokinetic Datamentioning

confidence: 99%

Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

et al. 2020

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Since the 1970s, outpatient parenteral antimicrobial therapy (OPAT) has been a viable option for patients who require intravenous antibiotics when hospitalization is not warranted. While the benefits of OPAT as a measure to improve the efficiency of healthcare delivery (i.e., reduced hospital days) and patient satisfaction are well-documented, OPAT is associated with a number of challenges, including line complications and reliance on daily healthcare interactions in some cases at home or in a clinic. To minimize the continued need for intensive healthcare services in the outpatient setting, there is trend toward patients self-administering antibiotics at home without the presence of healthcare workers, after adequate training. In most cases, patients administer the antibiotics through an established intravenous catheter. While this OPAT practice is becoming more accepted as a standard of care, the potential for line complications still exists. Outpatient subcutaneous antimicrobial therapy (OSCAT) has become an increasingly accepted alternative route of administration of antibiotics to IV by French infectious diseases physicians and geriatricians; however, currently, no antibiotics are approved to be administered subcutaneously. Antibiotics with longer half-lives that are completely absorbed and have a favorable local tolerability profile are ideal candidates for OSCAT and have the potential to maximize the quality and efficiency of parenteral antibiotic delivery in the outpatient setting. The increasing development of wearable, on-body subcutaneous delivery systems make OSCAT even more viable as they increase patient independence while avoiding line complications and potentially removing the need for direct healthcare professional observation.

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