Subcutaneous seeding of hepatocellular carcinoma after percutaneous needle biopsy

Schotman, S N; Man, R A de; Stoker, J.; Zondervan, Pieter E.; Ijzermans, J. N. M.

doi:10.1136/gut.45.4.626

Cited by 50 publications

(19 citation statements)

References 18 publications

(4 reference statements)

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“…As a rule, it was performed in the hospital where the patients were first seen. Our policy is not to perform a percutaneous biopsy of the tumour because of the risk of subcutaneous seeding [19]. In this study, 2 of the 35 patients (6%) that underwent percutaneous tumour biopsies developed subcutaneous tumour seeding related to the biopsies during follow-up.…”

Section: Discussionmentioning

confidence: 94%

Good Outcomes after Resection of Large Hepatocellular Carcinoma in the Non-Cirrhotic Liver

Verhoef

Man²,

Zondervan³

et al. 2004

Dig Surg

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Background: The results of partial liver resection of hepatocellular carcinoma (HCC) in non-cirrhotic livers are not well known. Therefore a retrospective study was conducted. Methods: The medical records of 180 patients with HCC were reviewed. In 40 patients (22%), HCC occurred in a non-cirrhotic liver. A detailed analysis of these patients was performed. The diagnosis HCC was based on imaging and/or percutaneous ultrasound-guided biopsy. A biopsy of the remaining liver and peroperative findings documented the absence of cirrhosis. Results: Twenty-two patients underwent partial liver resection. There was no surgical mortality. The median tumour diameter in the operated patients was 10 cm. Survival rates for operated patients at 1 and 5 years were 96 and 68%, respectively. Significant factors reducing survival were portal vein thrombosis, positive lymph nodes, microscopic vascular invasion and tumour recurrence. Tumour size at the initial moment of diagnosis was not of predictive value. After surgery with curative intent disease-free interval at 1 and 5 years were 86 and 56%, respectively. Conclusion: In selected patients without cirrhosis, HCC can be treated successfully by surgical resection, independent of the tumour diameter, with a 5-year survival rate of 68%.

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Section: Discussionmentioning

confidence: 94%

Good Outcomes after Resection of Large Hepatocellular Carcinoma in the Non-Cirrhotic Liver

Verhoef

Man²,

Zondervan³

et al. 2004

Dig Surg

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“…Subcutaneous seeding after diagnostic puncture of the liver in patients with HCC has been described 26 . Llovet et al 27 described neoplastic seeding in 13 per cent of patients with HCC after percutaneous radiofrequency ablation with a cooled-tip needle.…”

Section: Discussionmentioning

confidence: 99%

Interstitial laser coagulation with temporary hepatic artery occlusion for patients with cirrhosis and irresectable hepatoma

Verhoef

Kuiper

Heisterkamp

et al. 2003

British Journal of Surgery

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“…Similar increased risk could be expected in cirrhotic individuals in whom a highly vascular lesion such as hepatocellular carcinoma is being percutaneously biopsied (Huang, 1996). Tumor seeding along the needle track after biopsy has also been reported as a complication in this population (Dubay, 2011;Huang, 1996;Schotman, 1999;Sood, 2002). A recent systematic review and meta-analysis showed that the overall incidence of needle track tumor seeding is 2.7%, or 0.9% per year (M.A.…”

Section: Biopsymentioning

confidence: 94%

Liver Transplantation for Hepatocellular Carcinoma (Hcc)

Mejía¹,

Nazario²,

Mantry³

2012

Liver Transplantation - Basic Issues

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Subcutaneous seeding of hepatocellular carcinoma after percutaneous needle biopsy

Cited by 50 publications

References 18 publications

Good Outcomes after Resection of Large Hepatocellular Carcinoma in the Non-Cirrhotic Liver

Good Outcomes after Resection of Large Hepatocellular Carcinoma in the Non-Cirrhotic Liver

Interstitial laser coagulation with temporary hepatic artery occlusion for patients with cirrhosis and irresectable hepatoma

Liver Transplantation for Hepatocellular Carcinoma (Hcc)

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