Subcutaneous sarcoidosis: report of two cases and review of the literature

Abstract

Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report here 2 new cases and review 83 cases reported in literature of subcutaneous sarcoidosis. Subcutaneous sarcoidosis present usually with asymptomatic firm nodules covered by normal-appearing skin, mostly on the forearms and legs. Diagnosis may require a high index of suspicion. In the vast majority of patients, subcutaneous nodules were the manifestation that allowed the diagnosis of systemic sarcoidosis. There is a strong association between subcutaneous sarcoidosis and bilateral hilar lymphadenopathy (72.7%). About 15% of patients have in order of frequency uveitis, parotitis, arthritis, mucositis, dactylitis, neurological and renal involvement, hepatosplenomegaly.

Isolated subcutaneous sarcoid-like granulomatous inflammation occurring at injection sites: 3 patients treated successfully with minocycline

“…Subcutaneous nodules are rare cutaneous manifestations of sarcoidosis occurring in up to 6% of cases, frequently manifesting on the forearms as indurated linear bands, although lesions can occur at any site. 1 , 2 , 3 In our patients, lesions developed on the bilateral posterior arms, which correspond to prior inoculation sites and differ from the common locations of subcutaneous sarcoidosis.…”

Sarcoidosis and chronic hepatitis C: treatment with prednisone and colchicine

“…Described by Darier and Roussy in 1906, they are considered rare manifestations, occurring in only 2% of individuals with sarcoidosis. 9 Other typical manifestations of the associated disease were central for its recognition. When isolated, sarcoid subcutaneous nodules become a true diagnostic challenge.…”

Polyarticular Arthritis and Skin Nodulosis in a 14‐Year‐Old Female

“…Fewer than 100 cases of subcutaneous sarcoidosis have been reported in the medical literature thus far. Most case reports are of females during the fourth or fifth decades of life, and co‐occurrence with arthritis has been present in some .…”