Subcutaneous Peripheral Nerve Stimulation for Treatment of Acute/Subacute Herpes Zoster-related Trigeminal Neuralgia

Abstract

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Effect of CT-Guided Gasserian Ganglion Block with Local Anesthetics and Steroids on Acute/Subacute Zoster-Related Trigeminal Neuralgia: A Multicenter Retrospective Study

“… 28 Gasserian ganglion block provides sedative effect, which reduces the excessive excitation of sympathetic nerve and the release of neurotransmitters. 9 Lidocaine makes the lesion area reach a painless state quickly and plays the role of muscle relaxant, vasodilator and improved microcirculation. 29 Dexamethasone provides anti-inflammatory, analgesic and immunosuppressive effects and prolongs the effect time when combined with local anesthetics.…”

“… 7 Acute zoster-related trigeminal neuralgia presents as facial pain within 30 days of zoster onset, characterized by severe burning pain and tingling in the skin of the innervated area, along with the occasional tearing or stabbing pain. 8 , 9 Subacute zoster-related trigeminal neuralgia is described as facial pain from 31 to 90 days after zoster onset. 8 , 9 Trigeminal postherpetic neuralgia (TPHN) is defined as dermatomal pain after zoster onset, resulting from acute and subacute zoster-related trigeminal neuralgia, which persists for over 3 months and is the most common and the most severe type.…”

“…8 , 9 Subacute zoster-related trigeminal neuralgia is described as facial pain from 31 to 90 days after zoster onset. 8 , 9 Trigeminal postherpetic neuralgia (TPHN) is defined as dermatomal pain after zoster onset, resulting from acute and subacute zoster-related trigeminal neuralgia, which persists for over 3 months and is the most common and the most severe type. TPHN is a refractory chronic neuropathic pain resulting from HZ virus infection, 10 which is accompanied by allodynia and hyperalgesia that may continue long after the resolution of mucocutaneous eruption.…”

Efficacy and Safety of Pulsed Radiofrequency in Herpes Zoster Related Trigeminal Neuralgia: A Systematic Review and Meta-Analysis

“… 3 , 4 As HZ virus invades gasserian ganglion (GG) or trigeminal nerve, the reactivation and replication of the virus would cause neuronal edema and necrosis of the infected ganglion and nerve, leading to zoster-related trigeminal neuralgia (TN), 5 , 6 which accounts for approximately 15%-20% HZ patients. 7 Nowadays it is also a challenging and intractable neuropathic pain, which is lack of completely effective treatment. In addition, previous studies indicated that zoster-related trigeminal pain was more refractory than herpetic neuralgia in areas from the cervical to lumbosacral level.…”

Рефрактерна Атипова Тригемінальна Невралгія, Асоційована З Реактивованою Герпесвірусною Інфекцією: Патогенетичний Зв’язок І Ефективність Комбінованого Противірусного Лікування

“…Krohel зі співавт. ще в 1976 році описали хронічну HSV-1-індуковану (Herpes simplex virus, HSV, вірус простого герпесу) нейропатію трійчастого нерва [23] [24]. Ураження структур мезолімбічної системи головного мозку, яке відбувається при вірус-індукованому скроневому медіанному склерозі [55] або автоімунних лімбічних енцефалітах, зумовлених автоантитілами до автоантигенів нейронів гіпокампів [17], може призводити до порушення механізмів центральної регуляції болю при тригемінальних невралгіях у людей.…”