Subcutaneous Panniculitis Lymphoma: Erythema Nodosum–Like

Risulo, Massimiliano; Rubegni, Pietro; Sbano, Paolo; Sammassimo, Simona; Nisi, Maria Caterina De; Leoncini, Lorenzo; Miracco, Clelia; Fimiani, Michele

doi:10.3816/clm.2006.n.065

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…[2][3][4] There have been various clinical presentations described in SPTCL, such as cases with an erythema nodosum-or cellulitis-like aspect, venous stasis-like ulceration, and alopecia. [3,[5][6][7] Our case had a different clinical presentation, simulating dermatitis artefacta.…”

Section: Discussionmentioning

confidence: 87%

A Case with an Indolent Course of Subcutaneous Panniculitis-Like T-Cell Lymphoma Demonstrating Epstein-Barr Virus Positivity and Simulating Dermatitis Artefacta

Soylu

Gül

Kılıç

et al. 2010

American Journal of Clinical Dermatology

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Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cytotoxic T-cell lymphoma. The disease has a poor prognosis in patients with the complication of hemophagocytic syndrome, especially in those with Epstein-Barr virus (EBV) positivity. A 20-year-old woman presented with multiple, itchy, purplish nodules and excoriations on both of her upper limbs. The histopathologic, immunohistochemical staining, and clonal T-cell receptor gene rearrangement examinations of skin lesions revealed the diagnosis of SPTCL. In situ hybridization performed for EBV was positive. There were no findings suggesting systemic involvement of SPTCL, or hemophagocytic syndrome. The lesions improved with systemic corticosteroid therapy and radiotherapy, with no recurrence. We present a patient with a protracted course of SPTCL in whom EBV positivity was demonstrated. This apparent conflict may be explained by geographic and ethnic variations in EBV infection. Further studies may shed light on the real relationship between EBV-RNA and the course of SPTCL.

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Section: Discussionmentioning

confidence: 87%

A Case with an Indolent Course of Subcutaneous Panniculitis-Like T-Cell Lymphoma Demonstrating Epstein-Barr Virus Positivity and Simulating Dermatitis Artefacta

Soylu

Gül

Kılıç

et al. 2010

American Journal of Clinical Dermatology

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“…There are a few reports regarding EN transforming into subcutaneous panniculitis lymphoma and Hodgkin lymphoma, however, EN transforming into pcALCL has not been reported. [7] To date, fewer than 10 cases with pcALCL occurring in AD and burn scar have been reported. [3–6] In this case, pcALCL developed at the site of EN after 20 years.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous anaplastic large cell lymphoma arising from a long-standing erythema nodosum

Ma¹,

Han

Fang³

2018

Medicine

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Rationale:Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN).Patient concerns:A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks.Diagnoses:The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. The second skin biopsy was performed in 2014 and she was diagnosed as pcALCL with stage IA.Interventions:She was treated with oral prednisone, cyclosporine, and thalidomide.Outcomes:One month later, the ulcerative lesion was decreased in size and became smooth and the patient achieved partial remission. She is still under treatment and has been monitored closely for 4 years.Lessons:The case suggested that stimulation of inflammation in the skin lesions for a long period might be related to clonal transformation into pcALCL and hence should be closely monitored. Immunosuppressive treatment may be effective and safe for patients with pcALCL at early stages.

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